Associação de alelos HLA e aborto espontâneo recorrente em uma população de São Luís/Maranhão, na região Nordeste do Brasil

Silva, Fábio França; Mesquita, Emygdia Rosa Rêgo Barros Pires Leal; Patrício, Fernando J.; Corrêa, Rita da Graça Carvalhal Frazão; Ferreira, Evaldo César Macau Furtado; Chein, Maria Bethânia da Costa; Brito, Luciane Maria Oliveira

doi:10.1590/so100-720320150005209

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…37,40 Another contribution of the immune system in spontaneous abortion is referred to as a response, in which Human Leukocyte Antigens (HLA) stimulate the maternal immune system against the presence of the fetus. 41 Regarding genetic changes, the polymorphisms of the vascular endothelial growth factor -VEGF stand out (this being an important factor in the regulation of fetal and placental angiogenesis), 8,42 VEGF 43 receptor polymorphism and growth factor polymorphism similar to insulin-2 -IGF-2 (main fetal-placental growth factor that stimulates trophoblast invasion and growth). 44 Chromosomal abnormalities represent one of the main causes of pregnancy loss, requiring a karyotype analysis in couples.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with spontaneous abortion: a systematic review

Oliveira

Marques

et al. 2020

Rev. Bras. Saude Mater. Infant.

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Objectives: to compile studies produced regardinggenetic and non-genetic risks factors associated with occurrence of spontaneous abortion. Methods: it talks about a systematic review article, with studies between January of 2008 to November of 2018 according to SciELO, PubMed, Lilacs and BVS. Results: in total, 567 articles were found. After applying the definedeligibility criteria, 44 articles made part of the review, being the majority published on Asia between 2008 and 2011, and 10 articles published on Brazil. Not genetic causes like sociodemographic factors and healthy state were among the most associated conditions of spontaneous abortion. Asiatic continent had predominance about the correlation of spontaneous abortion with factors related to life style like obesity, smoking and labor activities, on the other hand, in the Americas, causes related to sociodemographics factors like low pay and low studies are high-lighted. Conclusions: the risk factors change about the occurrence region, being important to make local studies capable of subsidize the implantation of public politics and to reduce abortions.

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Section: Discussionmentioning

confidence: 99%

Factors associated with spontaneous abortion: a systematic review

Oliveira

Marques

et al. 2020

Rev. Bras. Saude Mater. Infant.

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Research progress of immune balance and genetic polymorphism in unexplained recurrent abortion

Kang,

Xie,

Chen

et al. 2023

Explor Immunol

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The etiology of recurrent spontaneous abortion (RSA) is extremely complex, as there are 40–50% of patients with unexplained miscarriages, known as unexplained RSA (URSA). URSA affects approximately 1–2% of females of childbearing age and has a massive impact on the physical and mental conditions of both patients and their families. The pathogenesis of the disease remains unclear, making its treatment complicated. In recent years, considerable progress has been made in the exploration of the URSA immune balance mechanism and it has been universally acknowledged that a balanced immune response (as abnormal immunity) may be the root cause of poor pregnancy outcomes. This review discussed and summarized the effects of immune cells and blocking antibodies (BAs) on URSA based on the current state of knowledge in this area. Additionally, molecular genetics also plays an essential role in the incidence rate of URSA since the role of genetic polymorphism in the pathogenesis of URSA has been thoroughly studied. Nonetheless, the outcomes of these studies are inconsistent, particularly across populations. This paper reviewed previous studies on URSA and maternal genetic polymorphism, focusing on and synthesizing the most important findings to date, and providing diagnostic recommendation for URSA patients with clinical symptoms.

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Associação de alelos HLA e aborto espontâneo recorrente em uma população de São Luís/Maranhão, na região Nordeste do Brasil

Abstract: It was shown that the HLA-A34 allele is a risk factor for recurrent spontaneous abortion, while the HLA-A24 and HLA-B*35 alleles are associated with protection, and no allele of the DRB1 locus was associated with RSA.

Cited by 2 publications

References 23 publications

Factors associated with spontaneous abortion: a systematic review

Factors associated with spontaneous abortion: a systematic review

Research progress of immune balance and genetic polymorphism in unexplained recurrent abortion

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Associação de alelos HLA e aborto espontâneo recorrente em uma população de São Luís/Maranhão, na região Nordeste do Brasil

Abstract: It was shown that the HLA-A*34 allele is a risk factor for recurrent spontaneous abortion, while the HLA-A*24 and HLA-B*35 alleles are associated with protection, and no allele of the DRB1 locus was associated with RSA.

Cited by 2 publications

References 23 publications

Factors associated with spontaneous abortion: a systematic review

Factors associated with spontaneous abortion: a systematic review

Research progress of immune balance and genetic polymorphism in unexplained recurrent abortion

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Abstract: It was shown that the HLA-A34 allele is a risk factor for recurrent spontaneous abortion, while the HLA-A24 and HLA-B*35 alleles are associated with protection, and no allele of the DRB1 locus was associated with RSA.