Low serum levels of 25-hydroxyvitamin D (25-OHD) in children with autism

Tostes, Márcia Helena Fávero de Souza; Polonini, Hudson; Gattaz, Wagner F.; Raposo, Nádia Rezende Barbosa; Baptista, Edilene Bolutari

doi:10.1590/s2237-60892012000300008

Cited by 36 publications

(19 citation statements)

References 8 publications

(4 reference statements)

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“…Vitamin D levels for normal controls in our study were 70.5 nmol/l which was less than that reported in Meguid (Egypt), Saad (Egypt), Brazil, and Saudi Arabia [33][34][35]37 but greater than faroe islands 38 and turkey 40 .…”

Section: Table 3: Spearman Correlation Between Serum and Dietary Vitacontrasting

confidence: 83%

“…This value seems lower than those reported in the studies conducted in Egypt, brazil, USA and Turkey 28,33,37,40 ,but greater than that reported from Faroe islands 38 . Vitamin D levels for normal controls in our study were 70.5 nmol/l which was less than that reported in Meguid (Egypt), Saad (Egypt), Brazil, and Saudi Arabia [33][34][35]37 but greater than faroe islands 38 and turkey 40 .…”

Section: Table 3: Spearman Correlation Between Serum and Dietary Vitacontrasting

confidence: 64%

“…35,36 . Another study from Brazil reported lower level of Vitamin D in children with ASD than controls and a mean serum value of 26.5 ng/mL 28,37 . In a study conducted in the Faroe Islands as part of a population based study, lower Vitamin D levels (mean : 9.9 ng/mL) were reported in 40 individuals (aged 15-24 years) with ASD, as compared to their normally developing siblings, parents, and age-and gender-matched healthy controls 38 .…”

Section: Table 3: Spearman Correlation Between Serum and Dietary Vitamentioning

confidence: 94%

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2016

IJPSR

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ABSTRACT:It is well known that main sources of Vitamin D are sun exposure and diet. There is a gap in our knowledge about the contribution of these factors to Vitamin D level among autistic children in Egypt. Aim: To determine Vitamin D dietary intake and sun exposure and their impact on vitamin D level. Methods and procedures: Serum Vitamin D levels were measured in 42 autistic and 40 healthy matched children. Dietary Vitamin D intake and sun exposure hours were collected using an adapted pre-validated food frequency questionnaire. Vitamin D intake was compared with recommended dietary intake (600 IU). Results and outcomes: Autistic children had significantly lower serum levels of 25-hydroxy Vitamin D than healthy children (P < 0.001) with 54.7% and 28.6% being Vitamin D deficient and insufficient, respectively. Dietary Vitamin D intake of both groups was significantly lower than recommended dietary intake. No correlations between serum Vitamin D level and dietary Vitamin D intake or Childhood Autism Rating Scale. Conclusion and implications: Vitamin D deficiency was found in autistic children and this may contribute to pathogenesis of the disease. There is a need to increase awareness about Vitamin D importance in children's diet.

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Section: Table 3: Spearman Correlation Between Serum and Dietary Vitacontrasting

confidence: 83%

Section: Table 3: Spearman Correlation Between Serum and Dietary Vitacontrasting

confidence: 64%

Section: Table 3: Spearman Correlation Between Serum and Dietary Vitamentioning

confidence: 94%

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2016

IJPSR

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“…These are: Humble et al (2010) (without a comparison group); Molloy et al (2010) (with a problematic comparison group); Meguid et al (2010); Mostafa and AL-Ayadhi (2012); De Souza Tostes et al (2012) and Gong et al (2014), four of which showed significantly lower levels of vitamin D in individuals with this diagnosis as compared to healthy comparison group (“Appendix”). Fernell et al (2010) demonstrated extremely low vitamin D levels in mothers of Somali origin living in Sweden with a child with ASD as compared to control group of Swedish mothers.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D in the General Population of Young Adults with Autism in the Faroe Islands

Kočovská

Andorsdóttir

Weihe

et al. 2014

J Autism Dev Disord

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Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in a cross-sectional population-based study in the Faroe Islands. The case group consisting of a total population cohort of 40 individuals with ASD (aged 15–24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons. There was a trend for males having lower 25(OH)D3 than females. Effects of age, month/season of birth, IQ, various subcategories of ASD and Autism Diagnostic Observation Schedule score were also investigated, however, no association was found. The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism.

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“…VDD is also often decreased in children with autism and other neurodevelopmental conditions like epilepsy [14,15]. In addition, lack of sun exposure on the eastern coast of North America during winter puts children at higher risk for Vitamin D deficiency [16].…”

Section: Discussionmentioning

confidence: 99%

Hypocalcemic Seizure Due to Severe Vitamin-D Deficiency in an Adolescent with Obesity and Autism

Carugno¹,

Ossa²,

Wyllie³

et al. 2018

Clin Pediatr OA

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Hypocalcemic seizures due to Vitamin D deficiency are rare in children beyond the neonatal period. In this case, a 12 year old female adolescent with intellectual disability, autism, obesity and a very restricted diet presented with hypocalcemic seizure secondary to Vitamin D Deficiency. A higher level of alertness about nutritional deficiencies must be maintained in the presence of dietary restrictions, particularly in children with developmental disabilities.

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Low serum levels of 25-hydroxyvitamin D (25-OHD) in children with autism

Abstract: Our findings attest to the importance of vitamin supplementation during pregnancy and in the treatment of children with autism, who tend to present low vitamin D consumption rates.

Cited by 36 publications

References 8 publications

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Vitamin D in the General Population of Young Adults with Autism in the Faroe Islands

Hypocalcemic Seizure Due to Severe Vitamin-D Deficiency in an Adolescent with Obesity and Autism

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