Avaliação a médio prazo do controle de fatores de risco de doença cardiovascular em coorte prospectiva de pacientes de alto risco tratados por intervenção coronária percutânea

Pavão, Rafael Brolio; Marin‐Neto, José Antônio; Novaes, Gustavo Caires; Pinto, Marcelo R.; Figueiredo, Geraldo Luiz de; Lago, Igor Matos; Filho, Moysés de Oliveira Lima; Lemos, Daniel Conterno; Tonani, Monique; Antloga, Cleide Marques; Oliveira, Luis Carlos Origa de; Marchini, Júlio Flávio Meirelles

doi:10.1590/s2179-83972013000200007

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…Of these, 7 patients did not undergo PCI and three others withdrew consent. Table 1 presents baseline data for the 187 remaining patients (15). Most patients (82%) were self-identified as white, 15% were self-identified as brown, and 3% as black.…”

Section: Resultsmentioning

confidence: 99%

“…The design and rationale of the SPARC (Sequence Variation in Platelet Aggregation in Response to Clopidogrel and acetylsalicylic acid) study have been described elsewhere (15). Briefly, this is a single-center, observational, prospective trial that enrolled patients from December 2009 to January 2011 who underwent PCI and had no contraindications to ASA or clopidogrel.…”

Section: Methodsmentioning

confidence: 99%

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Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients

Marchini

Pinto

Novaes

et al. 2017

Braz J Med Biol Res

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Clopidogrel and aspirin are the most commonly used medications worldwide for dual antiplatelet therapy after percutaneous coronary intervention. However, clopidogrel hyporesponsiveness related to gene polymorphisms is a concern. Populations with higher degrees of genetic admixture may have increased prevalence of clopidogrel hyporesponsiveness. To assess this, we genotyped CYP2C19, ABCB1, and PON1 in 187 patients who underwent percutaneous coronary intervention. Race was self-defined by patients. We also performed light transmission aggregometry with adenosine diphosphate (ADP) and arachidonic acid during dual antiplatelet therapy. We found a significant difference for presence of the CYP2C19*2 polymorphism between white and non-white patients. Although 7% of patients had platelet resistance to clopidogrel, this did not correlate with any of the tested genetic polymorphisms. We did not find platelet resistance to aspirin in this cohort. Multivariate analysis showed that patients with PON1 and CYP2C19 polymorphisms had higher light transmission after ADP aggregometry than patients with native alleles. There was no preponderance of any race in patients with higher light transmission aggregometry. In brief, PON1 and CYP2C19 polymorphisms were associated with lower clopidogrel responsiveness in this sample. Despite differences in CYP2C19 polymorphisms across white and non-white patients, genetic admixture by itself was not able to identify clopidogrel hyporesponsiveness.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients

Marchini

Pinto

Novaes

et al. 2017

Braz J Med Biol Res

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“…Os pacientes tratados percutaneamente mostram-se mais propensos à adesão de medidas de prevenção secundária quando comparados com aqueles tratados cirurgicamente. 14 Os resultados no questionário MICRO-Q foram proporcionais à renda familiar, ou seja, quanto maior a renda, maior a pontuação. Aqueles com renda superior a três salários mínimos e com mais de oito anos de estudo, obtiveram melhores resultados.…”

Section: Discussionunclassified

Evaluation of the Level of Knowledge of Patients With Regards to the Treatment of Acute Coronary Syndrome Using the Maugerl Cardiac Prevention-Questionnaire

Cata-Preta¹,

Silqueira²,

Passaglia³

2019

Reme Revista Mineira De Enfermagem

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Objetivos: descrever o nível de conhecimento do paciente em tratamento de síndrome coronariana aguda (SCA). Método: estudo transversal com aplicação do Maugerl Cardiac Prevention-Questionnaire aos pacientes com SCA submetidos ao cateterismo cardíaco (CATE) após alta da unidade coronariana de cuidados intensivos. Resultados: amostra composta de 50 pacientes, 76% do sexo masculino, com média de idade de 58 anos (±10.2), sendo que 72% apresentaram como principal fator de risco a hipertensão arterial sistêmica. Os pacientes apresentaram, de modo geral, bom índice de desempenho no questionário, apesar do baixo nível de escolaridade. A pontuação média no questionário foi proporcional à renda familiar (p=0,002) e ao nível de escolaridade (p=0,007). Conclusão: a utilização do instrumento O Micro-Q permitiu constatar que a escolaridade e o nível socioeconômico influenciam no entendimento do paciente sobre a própria doença. O instrumento foi uma ferramenta útil para a avaliação do nível de conhecimento do paciente acometido pela SCA, pois a adequada caracterização do perfil dos pacientes atendidos em cada instituição torna-se uma ferramenta facilitadora para planejamentos assistenciais e programas de vigilância em saúde. Palavras-chave: Síndrome Coronariana Aguda; Doença das Coronárias; Educação em Saúde. ABSTR ACT Objectives: describing the level of knowledge of patients undergoing treatment for Acute Coronary Syndrome (SCA). Method: cross-sectional study applying the Maugerl Cardiac Prevention-Questionnaire to SCA patients who underwent cardiac catheterization (CATE) after being discharged from the coronary intensive care unit. Results: the sample was made up of 50 patients, 76% of whom were males, with a mean age of 58 years old ((±10.2). The main risk factor for most of them was the systemic arterial hypertension. Patients presented, in general, a good performance in the questionnaire, despite their low educational level. The mean score in the questionnaire was proportional to family income (p=0.002) and to educational level (p=0.007). Conclusion: using the MICRO-Q instrument allowed this work to observe that educational level and socioeconomic level influence the understanding of the patient with regards to their own disease. The instrument was a useful tool to evaluate the level of knowledge of the patient affected by the SCA, since the adequate characterization of the profile of the patients cared for in each institution becomes a tool that makes it easier to plan assistance and health surveillance programs.

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“…Another important aspect to note is the lack of data from the Brazilian population, whose own cultural and social characteristics influence the adherence to treatment, besides the fact that its genetic composition differs from populations assessed in the large registries of the United States and Europe. [3][4][5][6] The aim of the present study was to evaluate the initial and late events of a non-selected cohort of patients undergoing DES implantation, comparing diabetic and non-diabetic patients.…”

Section: Definitions and Primary Outcomementioning

confidence: 99%

Resultados iniciais e tardios de diabéticos tratados com stents farmacológicos do Registro Safira

Flávio

Marchini

Salman

et al. 2013

Rev. Bras. Cardiol. Invasiva

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Background: The percutaneous treatment of coronary artery disease has been revolutionized by the use of drug-eluting stents (DES). However, its use in the daily practice involves patients with more complex clinical and angiographic characteristics than those found in randomized trials. This registry was designed to characterize diabetic patients and their outcomes following DES implantation in our country. Methods: Prospective single-center registry enrolling consecutive patients after DES implantation. Clinical, angiographic and procedurerelated data, as well as early and long-term outcomes were recorded. The primary endpoint, including cardiac death, myocardial infarction or target lesion revascularization, was compared between diabetics and non-diabetics. Results: We evaluated 1,670 patients treated with DES from 2002 to 2012 with a follow-up of 3.2 ± 2.5 years. One third of the patients were diabetic and had lower event-free survival when compared to non-diabetic patients (79.4% vs. 82.6%; P = 0.015). The adjusted odds ratio, however, was 1.22 (95% CI, 0.89-1.69) and was not significant. A significantly lower event-free survival was observed in the subgroup of patients receiving insulin, whereas it was similar for diabetic and nondiabetic patients in the subgroup not receiving insulin (68.7% vs. 83.9% vs. 82.8%, respectively; P < 0.01). The adjusted odds ratio was 1.72 (95% CI, 1.13-2.63) higher for diabetic patients receiving insulin when compared to the remaining patients.

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Avaliação a médio prazo do controle de fatores de risco de doença cardiovascular em coorte prospectiva de pacientes de alto risco tratados por intervenção coronária percutânea

Cited by 8 publications

References 15 publications

Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients

Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients

Evaluation of the Level of Knowledge of Patients With Regards to the Treatment of Acute Coronary Syndrome Using the Maugerl Cardiac Prevention-Questionnaire

Resultados iniciais e tardios de diabéticos tratados com stents farmacológicos do Registro Safira

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