Intra-articular injections with corticosteroids and sodium hyaluronate for treating temporomandibular joint disorders: a systematic review

Machado, Eduardo; Bonotto, Daniel; Cunali, Paulo Afonso

doi:10.1590/s2176-94512013000500021

Cited by 39 publications

(45 citation statements)

References 18 publications

(22 reference statements)

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“…Arthroscopy [12], simple lysis and lavage, and the use of hydraulic pressure in the upper joint space were found to be highly effective in reestablishing normal MMO and relieving the symptoms [13], despite the disc position not having been corrected.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

Al-Delayme

Alnuamy

Hamid

et al. 2016

J. Maxillofac. Oral Surg.

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Objective The objective of this study was to determine average improvement during the rest and active mouth opening after ultrasound guided platelets rich plasma injection in the tempromandibular superior joint space for the patients complaining from non-reducing disk displacement. Patients and Methods Thirty-four patients with non-reducing disk displacement underwent guided ultrasound injection of platelet rich plasma to the upper joint space. The extent of maximal mouth opening, chewing efficiency, sound intensity of the TMJ, and tenderness of the TMJ and the masticatory muscles at rest, motion and mastication were thoroughly assessed at the beginning of the study and scheduled for next follow-up at 1st, 3rd, and 6th months. Results Injection with platelets rich plasma was significantly more effective in improvements of the extent of maximal mouth opening, statistics result demonstrated a significant reduction in the VAS values of pain at rest, motion and mastication compared to the baseline VAS values. Conclusion PRP injection to the upper temporomandibular joint space provided improvement in signs and symptoms of patient with non-reducing disk displacement of the temporomandibular joint.

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Section: Introductionmentioning

confidence: 99%

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

Al-Delayme

Alnuamy

Hamid

et al. 2016

J. Maxillofac. Oral Surg.

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“…Corticosteroids are established anti-inflammatory agents with demonstrable, short-term, benefits when injected intra-articularly to treat shoulder impingement syndrome or osteoarthritis of peripheral joints [11][12][13][14][15]. Intra-articular corticosteroid injections are beneficial in rheumatoid arthritis and have been shown to provide symptomatic relief for up to 3 months duration [16].…”

mentioning

confidence: 99%

Intra-articular facet joint injections for low back pain: a systematic review

et al. 2016

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PurposeEvidence supporting the use of therapeutic intra-articular facet joint injections for patients with suspected facet joint pain is sparse. A systematic review including a narrative synthesis was carried out to determine if intra-articular facet joint injections with active drug are more effective in reducing back pain and back pain-related disability than a sham procedure or a placebo/inactive injection. Secondly, to determine if intra-articular facet joint injections with active drug or placebo/inactive injection are more effective in reducing back pain and back pain-related disability than conservative treatment. Methods Medline, EMBASE, CINAHL, CENTRAL, Index to Chiropractic Literature and the Cochrane Central Register of Controlled Trials were searched from inception through April 2015. Data were screened and single extraction with independent verification and risk of bias assessment was performed. Results A total of 391 records were screened, and six trials were included. The trials included were small (range 18-109 participants) and overall in terms of pain and disability outcomes most were inconclusive. Only two of the trials report any significant between-group differences in pain (mean difference -1.0, 95 % CI -2.0 to -0.1) and (p = 0.032) or disability (mean difference -3.0, 95 % CI -6.2 to 0.2) and (p = 0.013) outcomes. Conclusions The studies found here were clinically diverse and precluded any meta-analysis. A number of methodological issues were identified. The positive results, whilst interpreted with caution, do suggest that there is a need for further high-quality work in this area.

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“…8,9 In previous studies, there are many ways to reduce joint inflammatory condition, such as HA and corticosteroids. 10,11 However, Link N can be another material for reducing inflammation. Because it has been used in intervertebral disc (IVD) degeneration, both in vivo and in vitro studies.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Link N on Mesenchymal Stem Cell Under IL-1β Stimulation

Yang¹,

Wang²,

Hsu

et al. 2017

UIP HEATH MED

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Objective: Temporomandibular joint (TMJ) arthritis can be induced by several inflammatory cytokines that may affect extracellular matrix (ECM) component expression. Link-N is exfoliated from Link protein (LP) which is one of the ECM components. It possesses ability to stimulate synthesis of ECM component. However, information regarding the potential of Link-N to modulate inflammatory process remains lacking. Methods:Mesenchymal stem cells (MSCs) derived from oral adipose tissues were isolated from dental operation under regulation of IRB, and were stained by the early stage stem cell markers (OCT4, NANOG, REX1, and SOX2). MSCs were under IL-1β (1ng/ml) or Link-N (1μg/ml) stimulation at 24 hours and 96 hours. Cell supernatant were collected then concentration quantification of cytokines was performed by Luminex multiplex assays. Results:MSCs showed the early stage stem cell markers. IP-10 and IL-6 increased significantly under IL1βstimulation, but Link-N did not. The protection marker, IL-4, IL-13 elevated during Link-N treatment compared with only IL-1β stimulation at 24, 96 hours. The chondrogenesis regulator, TGF-β, increased significantly compared with only IL-1β stimulation at 96 hours. Conclusion:During inflammation, Link-N can inhibit inflammatory response. On the other hand, it can enhance protection marker and chondrogenesis regulator expression. Link N may provide additional effect to assist joint repair.

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Intra-articular injections with corticosteroids and sodium hyaluronate for treating temporomandibular joint disorders: a systematic review

Cited by 39 publications

References 18 publications

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

Intra-articular facet joint injections for low back pain: a systematic review

The Effect of Link N on Mesenchymal Stem Cell Under IL-1β Stimulation

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