Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery

Abstract

Polymeric stabilizers have received attention in the preparation of nanostructured systems due to their ability to enhance formulation stability. Considering this, the objective of this work was to prepare poly(ε-caprolactone) nanocapsules using the pullulan as a polymeric stabilizer. The nanocapsules were prepared using the interfacial deposition method of preformed polymers and they were characterized in terms of pH, average diameter, polydispersity index, zeta potential, beclomethasone dipropionate content, encapsulation efficiency, photostability and drug release profiles. The formulations showed physicochemical characteristics consistent with nanocarriers for drug delivery such as: average diameter lower than 270 nm, polydispersity indexes lower than 0.2, negative zeta potential (-22.7 to -26.3 mV) and encapsulation efficiencies close to 100%. In addition, the nanocapsules were able to delay the beclomethasone dipropionate photodegradation under UVC radiation and by the dialysis bag diffusion technique, the nanocapsules were able to prolong the drug release. Thus, pullulan could be considered an interesting excipient to formulate polymeric nanocapsules. Uniterms:Pullulan. Nanocapsules/diffusion technique. Pullulan/polymeric stabilizer. Biocompatible polymers. Beclomethasone dipropionate/nanocapsules.

Pulpal response to mineral trioxide aggregate containing phosphorylated pullulan-based capping material

“…It has been used as a coating of food and packaging material in food industry and pharmaceuticals, such as the cover of capsules [16][17][18][19] . Moreover, it can be molded into nanoparticles or nanogels which have been utilized for efficient drug delivery 20,21) . On the other hand, MTA is proven as a DPC material with excellent biocompatibility and higher success rate 22,23) .…”