The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Abstract

Vegetable oils present important pharmacological properties, which gained ground in the pharmaceutical field. Its encapsulation in nanoemulsions is considered a promising strategy to facilitate the applicability of these natural compounds and to potentiate the actions. These formulations offer several advantages for topical and systemic delivery of cosmetic and pharmaceutical agents including controlled droplet size, protection of the vegetable oil to photo, thermal and volatilization instability and ability to dissolve and stabilize lipophilic drugs. For these reasons, the aim of this review is to report on some characteristics, preparation methods, applications and especially analyze recent research available in the literature concerning the use of vegetable oils with therapeutic characteristics as lipid core in nanoemulsions, specially from Brazilian flora, such as babassu (Orbignya oleifera), aroeira (Schinus molle L.), andiroba (Carapa guaianiensis), casca-de-anta (Drimys brasiliensis Miers), sucupira (Pterodon emarginatus Vogel) and carqueja doce (Stenachaenium megapotamicum) oils.Uniterms: Plant oils/nanoemulsions/preparation. Plant oils/biological applications. INTRODUCTIONThe use of submicrometric colloidal nanocarriers such as nanoparticles (NP) lipid and polymeric, nanoemulsions (NE), microemulsions (ME), liposomes, and polymeric micelles is considered a promising system in the pharmaceutical field, because they have numerous advantages over traditional formulations such as: sustained release of the active element; solubilization of lipophilic molecules; use for different routes of administration; protection from chemical and enzymatic degradation of labile molecules; reduction of vegetable oils (VO) volatilization, side effects and dose (Mäder, Mehnert, 2005;Mehnert, Mäder, 2001;Gref, Couvreour, 2006;Couvreur, Vauthier, 2006; Panyam, Labhasetwar, 2003;Soppimath et al., 2001;Ai et al., 2011; Contri et al., 2012;Contri et al., 2014;Dimer et al., 2014;Severino et al., 2015;Frank et al., 2015;Asbahani et al., 2015). However, all systems differ thermodynamic stability, structure, chemical composition, efficiency encapsulation and types of application (Mäder, Mehnert, 2005;Ai et al., 2011).The development of suitable nanocarriers for pharmaceutical or cosmetic application requires the adequate selection of their adjuvants such as polymers for nanocapsules (NC), surfactants, and oils (Schaffazick et al., 2003;Alvarez-Román et al., 2001;Bouchemal et al., 2004;Friedrich et al., 2008). Recently, special attention has been given to the type of oily phase used as the core in the preparation of NE. VO has been preferred not only due to the concept that it is safe and biocompatible, but mainly because of the diversity of benefits, and the complex composition of fatty acids can exercise under the skin, protecting it against dehydration, solar radiation, inflammation, insect attack, microorganisms, and viruses (Tadros, Kessell, 2004;Bloise, 2003;Oyedeji, Okeke, 2010;Bakkali et. al., 2008;Harris, 2002; Contri et al, ...

Current knowledge on use of essential oils as alternative treatment against fish parasites

“…It has been considered to be a major disadvantage in relation to fish farming, since it hinders making these compounds available in water. Nanoemulsions offer several benefits, including sustained release, increased absorption rate and therapeutic potency and reduced toxicity and drug concentration (Bajerski et al, 2016). They may also improve the low water solubility of EOs and their major compounds.…”

The Properties and Application of Argan Oil in Cosmetology

“…[97] At the same time, they exhibit bioactivity, which can reduce transepidermal water loss. [102] It is also possible to use a crude extract from argan press-cake as sole emulsifier to stabilize nanoemulsions. [100] Paper [101] presents methods of forming nanoemulsions their properties and applications.…”

“…[100,108,114,115] The use of nanoparticles improves the stability of chemically unstable active ingredients and their controlled release. [102,117,118] Nanostructured lipid carriers with the addition of argan oil in work [119,120] were used to produce semisolidgels, which were tested to determine their textural and sensory properties. [102,117,118] Nanostructured lipid carriers with the addition of argan oil in work [119,120] were used to produce semisolidgels, which were tested to determine their textural and sensory properties.…”

Development and in vivo evaluation of the moisturising potential of cosmetic formulations containing Babassu (Orbignya phalerata Martius) oily extract

“…Cosmetic products based on vegetable oils help protect the skin from excessive fluid loss, allow skin respiration and assimilate sunlight (1). The oil extracted from Babassu (Orbignya phalerata Martius) coconut almonds has generated interest in the cosmetics industry, becoming a major candidate for application in cosmetic products, mainly for topical use (2)(3)(4). Babassu is the generic name given to the oil palm trees belonging to the Palmae family that are members of the genera Orbignya and Attalea.…”

“…Produtos cosméticos à base de óleos vegetais ajudam a proteger a pele da perda excessiva de fluidos, permitem a respiração da pele e assimilam a luz solar (1). O óleo extraído das amên-doas do coco de Babaçu (Orbignya phalerata Martius) gerou interesse na indústria cosmética, tornando-se um importante candidato para aplicação em produtos cosméticos, principalmente para uso tópico (2)(3)(4). Babaçu é o nome genérico dado às palmeiras oleaginosas pertencentes à família Palmae que são membros dos gêneros Orbignya e Attalea.…”