Stability of Tilo® tablets formulation obtained from dry extract of Justice pectoralis Jacq.

Rodriguez-Chanfrau, Jorge E.; Nuñez-Figueredo, Yanier; Fuste-Moreno, Viviana

doi:10.1590/s1984-82502015000100019

Cited by 2 publications

(2 citation statements)

References 7 publications

(5 reference statements)

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“…In a study by Chanfrau et al, reflux and Ultrasonic-Assisted Extraction methods were compared. As a result of the study, it was found that reflux provides a higher coumarin yield, and the use of low-frequency ultrasound in the extraction method provides a higher coumarin yield than high-frequency ultrasound (74).…”

Section: Ultrasonic-assistedmentioning

confidence: 90%

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Mini-Review on Coumarins: Sources, Biosynthesis, Bioactivity, Extraction and Toxicology

Elmusa,

Elmusa

2024

JOTCSA

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Coumarins are a class of naturally occurring compounds found in various plants, fungi, and microorganisms, each with a unique chemical profile. These compounds exhibit a broad range of bioactivities, including antithrombotic, anti-inflammatory, antioxidant, antimicrobial, antiviral, anticancer, and neuroprotective properties. The effective extraction of coumarins, facilitated by methods such as maceration and microwave-assisted extraction, is integral to unlocking their potential across various applications. Nevertheless, safety and toxicology considerations assume paramount importance, particularly in pharmaceuticals, cosmetics, and food additives. While moderate dietary consumption of coumarin-rich foods is generally safe, excessive intake, whether through foods or supplements, raises concerns linked to hepatotoxicity and photosensitivity. Notably, specific coumarin derivatives, including the widely used anticoagulant warfarin, necessitate precise dosing and vigilant monitoring to mitigate the risk of bleeding complications. In conclusion, the versatile biological activities of coumarins underscore their significance; yet, their safety and toxicity profiles are contingent on multiple factors, encompassing compound type, dosage, and individual susceptibility. This review provides a holistic understanding of coumarins, encompassing their natural origins, biosynthesis, bioactivity spectrum, extraction techniques, and insights into safety, and toxicology.

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Section: Ultrasonic-assistedmentioning

confidence: 90%

“…The cavitation generated by ultrasound disrupts cell walls and facilitates the release of coumarins into the solvent (70). UAE is known for its shorter extraction times, reduced solvent consumption, and improved extraction efficiency (74).…”

Section: Ultrasonic-assistedmentioning

confidence: 99%

Mini-Review on Coumarins: Sources, Biosynthesis, Bioactivity, Extraction and Toxicology

Elmusa,

Elmusa

2024

JOTCSA

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Eco-friendly extraction and simultaneous determination of two coumarins in Justicia pectoralis (Acanthaceae)

et al. 2020

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Justicia pectoralis (Acanthaceae) is employed in folk medicine for its analgesic, anti-inflammatory and sedative effects and to treat respiratory diseases. It is known for properties of its coumarins, 1,2-benzopyrone and umbelliferone. A green, simple, fast, and inexpensive ultrasound-assisted extractive (UAE) method for extracting umbelliferone and 1,2-benzopyrone from Justicia pectoralis was optimized. Additionally, a HPLC analytical method was developed and validated for the simultaneous determination of both coumarins. The Box-Behnken design and response surface methodology were used to evaluate the UAE process. Ethanol concentration, extraction time, plant-to-solvent ratio were the independent variables studied and the coumarin content was the dependent one. The HPLC-UV/VIS method was validated in terms of recovery, linearity, accuracy, precision and robustness, proving to be valuable for the quality control of Justicia pectoralis extract and in the development of its herbal products. Results show that the optimal UAE conditions were: ethanol concentration of 15% (w/w), extraction time of 34 min and plant-to-solvent ratio of 0.1 g/mL. The predicted values of coumarin contents (22.16 µg/mL - umbelliferone and 163.86 µg/mL - benzopyrone) were determined under the optimal UAE conditions and proved that UAE is an efficient and eco-friendly extractive process for the production of aerial part extracts from Justicia pectoralis.

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Stability of Tilo® tablets formulation obtained from dry extract of Justice pectoralis Jacq.

Cited by 2 publications

References 7 publications

Mini-Review on Coumarins: Sources, Biosynthesis, Bioactivity, Extraction and Toxicology

Mini-Review on Coumarins: Sources, Biosynthesis, Bioactivity, Extraction and Toxicology

Eco-friendly extraction and simultaneous determination of two coumarins in Justicia pectoralis (Acanthaceae)

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