Effects of Hypericum perforatum on turning behavior in an animal model of Parkinson's disease

Vecchia, Débora Dalla; Schamne, Marissa Giovanna; Ferro, Marcelo Machado; Santos, Ana Flávia Chaves dos; Latyki, Camila Lupepsa; Lara, Danilo Vieira de; Ben, Juliana; Moreira, Eduardo Luiz Gasnhar; Prediger, Rui Daniel; Miyoshi, Edmar

doi:10.1590/s1984-82502015000100012

Cited by 9 publications

(5 citation statements)

References 19 publications

(18 reference statements)

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“…Some of these are effective in the treatment of neurological diseases; some are useful for cardiovascular, respiratory, and gastrointestinal diseases while others have chemotherapeutic and antibacterial effects. Some of the important phytochemicals of the plants (Table 4) including alkaloids (like nicotine and scopolamine) are reported to have anxiolytic, antidepressant, and anti-Parkinson activities [15][16][17][18], saponins (like bacosides) have been reported for anxiolytic, antiepileptic, antiamnesia, and neuroprotective and memory enhancement activities [19][20][21][22], terpenoids (like cannabigerol, tetrahydrocannabinol, and cannabidiol) are reported for their neuroprotective effects [23], flavonoids (like kaempferol, luteolin, quercetin, rutin, and hesperidin) have been reported for their anxiolytic, antidepressant, antiepileptic, anti-Alzheimer, and neuroprotective and memory enhancement activities [24][25][26][27][28][29][30], glycosides (like hastatoside and verbenalin) are reported for sleep promoting activity [31], steroids (like sitoindosides VII-X and withaferin-A) have been reported for anxiolytic activity [32].…”

Section: Resultsmentioning

confidence: 99%

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

Khan

Shah

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background. Almost every region of Pakistan is stacked with a large number of medicinal plants. Due to high cost and unavailability of allopathic medicines for the neurological diseases, especially in rural areas, traditional healers prescribe phytotherapy for various neurological diseases like epilepsy, depression, anxiety, insomnia, Alzheimer, and migraine. Such treatments are considered to be most effective by the native people. Methods. The data was collected from articles published on medicinal plants of various districts of Pakistan, using article search engines like Medline, Pubmed, Web of Science, Science Direct, and Google Scholar. Also, information regarding various neurological uses and mode of applications of medicinal plants was obtained from traditional healers, folk medicine users, and local elderly people having knowledge of medicinal plants. Results. A total of 54 families were found to be used in various neurological diseases, of which the highest use was of Solanaceae (22.22%), Asteraceae (12.96%), Lamiaceae, Papaveraceae, and Poaceae, 9% each, and Caprifoliaceae, Cucurbitaceae, Rhamnaceae, and Rosaceae, 5.5% each. According to districts, 15% of plants that were effective in neurological affections were found in Bahawalpur, 11% in Swat, 8% in Muzaffarabad, 7% in Malakand, and 6% in Bahawalnagar, Dir, Gilgat, and Sarghoda each, with 5% in Dera ghazi khan and Jhelum each. According to the plant’s habit, out of total of 103 plants, 61.15% were found to be herbs, 22.33% trees, 11.65% shrubs, and 4.85% climbers. According to the part used of plant, whole plant, leaves, fruits, roots, seeds, and flowers were found to be used 32.03%, 24.27%, 20.38%, 16.50%, 13.59%, and 11.65%, respectively. According to disease’s types, 45.63% were found to be effective in insomnia, 31.06% in epilepsy 12.62% in depression, 6.80% in anxiety, 7.77% in hysteria, and 5.88% in migraine. Conclusion. Taking into consideration this useful knowledge on medicinal properties of the plants for curing neurologic diseases, it is believed that research in areas of ethnomedicine and ethnopharmacology can bring auspicious results that have potential of adding value to the very rich natural resources of Pakistan. This study will help all the researchers from diverse backgrounds working on plants based medicine for neurological diseases.

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Section: Resultsmentioning

confidence: 99%

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

Khan

Shah

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…In a study investigating the effects of H. perforatum in an animal model of PD, different doses of H. perforatum (100, 200, or 400 mg/kg) were administered to rats for 35 consecutive days and the turning behavior was evaluated at three different time points. The results showed that all doses of H. perforatum were effective in reducing the number of contralateral turns in all days of evaluation, which was proposed to be due to counteracting the overexpression of DA receptors in the lesioned striatum (Vecchia et al, ). Moreover, Gómez del Rio et al () evaluated the protective role of chronic administration of two standardized extracts of H. perforatum : SHP1 extract rich in hyperforin (6%) and SHP2 extract poor in hyperforin (0.2%) on rotenone‐induced PD in rats.…”

Section: Effects Of H Perforatum and Its Constituents On Neurodegenerative Diseasesmentioning

confidence: 96%

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder with a variety of motor and nonmotor symptoms affecting more than 3% of individuals over the age of 75 (De Lau & Breteler, 2006). A limited number of studies have been conducted to investigate the effects of H. perforatum in animal models of PD (Gomez del Rio et al, 2013;Kiasalari et al, 2016;Vecchia et al, 2015). In a study conducted by Kiasalari et al (2016), treatment of intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats with H. perforatum hydroalcoholic extract at a dose of 200 mg/kg/day attenuated the symptoms of PD and exerted protective effects via attenuation of DNA fragmentation, astrogliosis, inflammation, and oxidative stress.…”

Section: Parkinson's Diseasementioning

confidence: 99%

Section: Parkinson's Diseasementioning

confidence: 99%

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Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action

Zirak

Shafiee

Soltani

et al. 2018

Journal Cellular Physiology

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Background Psychiatric disorders are substantially associated with reduced quality of life and increased mortality. Depression and anxiety are two of the most common psychiatric disorders that often co‐occur with each other as well as with other mental health conditions. Because of the limitations of currently available antidepressant therapies, there is a need for agents with improved efficacy and less adverse effects. Hypericum perforatum, widely known as St. John's wort, is a perennial herbaceous plant most well known for its antidepressant properties. Methods We reviewed the available in vitro, in vivo, and clinical evidence on the efficacy, safety, and mechanisms of action of St. John's wort and its active constituents in the treatment of psychiatric and neurodegenerative disorders. Results Several interesting data have been reported about the antidepressant properties of H. perforatum in clinical trials with different designs. In particular, a number of antidepressant‐controlled trials demonstrated that H. perforatum and its active ingredients, hypericin and hyperforin, possess antidepressant properties similar to those of tricyclic antidepressants and selective serotonin reuptake inhibitors but with fewer and milder side effects. Conclusion St. John's wort may exert potent antidepressant effects and represents an efficacious and safe treatment. However, the current clinical evidence regarding the efficacy of H. perforatum in other psychiatric and neurodegenerative disorders is not sufficient to draw a robust conclusion.

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“…Their neuroprotective activities are attributed to their antioxidant potential, anti-inflammatory actions, and alteration of signaling pathways ( Basli et al, 2012 ; Moosavi et al, 2016 ). While managing neurodegenerative, novel therapeutic strategies support the application on antioxidant polyphenols as monotherapy or antioxidant cocktail formulation ( Vecchia et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-Parkinson Potential of Silymarin: Mechanistic Insight and Therapeutic Standing

Ullah

Khan

2018

Front. Pharmacol.

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Parkinson’s disease (PD) involves aggregation of α-synuclein and progressive loss of dopaminergic neurons. Pathogenesis of PD may also be related to one’s genetic background. PD is most common among geriatric population and approximately 1–2% of population suffers over age 65 years. Currently no successful therapies are in practice for the management of PD and available therapies tend to decrease the symptoms of PD only. Furthermore, these are associated with diverse range of adverse effects profile. The neuroprotective effects of polyphenols are widely studied and documented. Among phytochemicals, silymarin is one of the most widely used flavonoids because of its extensive therapeutic properties and has been indicated in pathological conditions of prostate, CNS, lungs, skin, liver, and pancreas. Silymarin is a mixture of flavonolignans (silybin, isosilybin, and silychristin), small amount of flavonoids (taxifolin), fatty acids, and other polyphenolic compounds extracted from the dried fruit of Silybum marianum and is clinically used for hepatoprotective effects since ancient times. Neuroprotective effects of silymarin have been studied in various models of neurological disorders such as Alzheimer’s disease, PD, and cerebral ischemia. The aim of the present study is to provide a comprehensive review of the recent literature exploring the effects of silymarin administration on the progression of PD. Reducing oxidative stress, inflammatory cytokines, altering cellular apoptosis machinery, and estrogen receptor machinery are mechanisms that are responsible for neuroprotection by silymarin, as discussed in this review. Additionally, because of poor aqueous solubility, the bioavailability of silymarin is low and only 23–47% of silymarin reaches systemic circulation after oral administration. Our primary focus is on the chemical basis of the pharmacology of silymarin in the treatment of PD and its mechanisms and possible therapeutic/clinical status while addressing the bioavailability limitation.

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Effects of Hypericum perforatum on turning behavior in an animal model of Parkinson's disease

Cited by 9 publications

References 19 publications

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

An Updated List of Neuromedicinal Plants of Pakistan, Their Uses, and Phytochemistry

Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action

Anti-Parkinson Potential of Silymarin: Mechanistic Insight and Therapeutic Standing

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