Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Abstract

An oleaginous fraction obtained from an alcohol extract of the fruit of Pterodon pubescens Benth. (FHPp) was microencapsulated in polymeric systems. These systems were developed using a complex coacervation method and consisted of alginate/medium-molecular-weight chitosan (F1-MC), alginate/ chitosan with greater than 75% deacetylation (F2-MC), and alginate/low-molecular-weight chitosan (F3-MC). These developed systems have the potential to both mask the taste of the extract, and to protect its constituents against possible chemical degradation. The influence of the formulation parameters and process were determined by chemical profiling and measurement of the microencapsulation efficiency of the oleaginous fraction, and by assessment of microcapsule morphology. The obtained formulations were slightly yellow, odorless, and had a pleasant taste. The average diameters of the microcapsules were 0.4679 µm (F2-MC), 0.5885 µm (F3-MC), and 0.9033 µm (F1-MC). The best formulation was F3-MC, with FHPp microencapsulation efficiency of 61.01 ± 2.00% and an in vitro release profile of 75.88 ± 0.45%; the content of vouacapans 3-4 was 99.49 ± 2.80%. The best model to describe the release kinetics for F1-MC and F3-MC was that proposed by Higuchi; however, F2-MC release displayed firstorder kinetics; the release mechanism was of the supercase II type for all formulations.Uniterms: Pterodon pubescens Benth./pharmacognosy. Sucupira. Microcapsules/preparation. Vouacapans. Alginate. Chitosan. Coacervation method. Natural polymers. Natural products.Uma fração oleaginosa obtida do extrato etanólico de frutos de Pterodon pubescens Benth (FHPp) foi microencapsulada em um sistema polimérico. Estes sistemas foram desenvolvidos utilizando o método de coacervação complexa, constituído de alginato/quitosana massa molecular média (F1-MC), alginato/ quitosana com desacetilação superior a 75% (F2-MC) e alginato/quitosana de massa molecular baixa (F3-MC). Estes sistemas desenvolvidos têm o potencial tanto de mascarar o sabor do extrato, quanto de protegê-lo de possível degradação química. A influência dos parâmetros de formulação e processo foram determinadas por caracterização química, determinação da eficiência de microencapsulação da fração oleaginosa e por avaliação morfológica da microcápsula. As formulações mostraram-se ligeiramente amareladas, inodoras e com sabor agradável. Os diâmetros médios das microcápsulas foram de 0,4679 µm (F2-MC), 0,5885 µm (F3-MC) e 0,9033 µm (F1-MC). A melhor formulação foi F3-MC, considerando-se que apresentou eficiência de encapsulação de 61,01 ± 2,00%, e perfil de liberação in vitro de 75,88 ± 0,45%; o conteúdo dos vouacapanos 3-4 foi 99,49 ± 2,80%. O melhor modelo para descrever a cinética de liberação foi o modelo proposto por Higuchi para F1-MC e F3-MC, entretanto, para F2-MC foi o modelo de primeira ordem, e o mecanismo de liberação foi do tipo super caso II para todas as formulações.Unitermos: Pterodon pubescens Benth./farmacognosia. Sucupira. Microcápsulas/preparação. Vouacapanos. Alginato. Quitosana. ...

Sucupira as a Potential Plant for Arthritis Treatment and Other Diseases

“…Reinas et al [ 16 ] have used thermal and infrared analysis methods to analyze the oilseed fraction of P . pubescens fruits and found a 0.11% residual mass at 500°C by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA).…”

“…The oil absorption spectra in the infrared region (FT-IR) showed bands at 1745 cm −1 (assigned to the C=O stretching of acetates), at 1244 cm −1 (indicating the asymmetric C-O stretching of acetates), at 1017 cm −1 (denoting asymmetric stretching of C-O-C esters), and at 732 cm −1 (reflecting a furan ring). Furthermore, Fourier transform Raman (FT-Raman) spectroscopy analysis showed a peak at 1673 cm −1 , reflective of the ester group of vouacapanes [ 16 ]. These data are useful for future inter- or intraspecies comparison of the physicochemical characteristics of the fruits' oilseed fraction.…”

“…The use of the alginate/low-molecular-weight chitosan polymer system with a mean polymer diameter of 0.5885 μ m and the highest encapsulation efficiency proved to be most promising. According to the authors, this system has the potential to mask the flavor of the extract and to protect it from possible chemical degradation [ 16 ].…”

“…The increasing use of the herbal Pterodon drugs aroused concern about their effectiveness. Therefore, several researchers have sought to preserve the characteristics of the plant extracts, since improper processing of the plants may result in degradation of the active compounds and, therefore, the loss of pharmacological activity [ 14 – 16 ]. This review presents a scientific overview of “sucupira” trees with reference to their ethnobotanical uses, phytochemistry, biological activity, and toxicity as well as the technological aspects of development phytotherapeutics.…”

Preparação de micropartículas de quitosana incorporadas de nanogéis de poli-(N-vinilcaprolactama-<i>co</i>-ácido itacônico-<i>co</i>-dimetacrilato de etilenoglicol) via secagem por pulverização para liberação controlada de cetoprofeno

“…Além da análise qualitativa dos nanogéis de poli(NVCL-co-AI-co-EGDMA) e da investigação da interação de cetoprofeno com a matriz polimérica dos nanogéis, a espectroscopia de infravermelho por transformada de Fourier (FTIR) foi utilizada para caracterizar, qualitativamente, as micropartículas de quitosana e de quitosana/poli(NVCL- -FILHO, 2016;REINAS et al, 2014;NETO et al, 2014;XIAO et al, 2012). vibrações de dobramento da interação N-H das cadeias de quitosana (1597 cm -1 ) para 1671 cm -1 .…”