Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology

Khalid, Ikrima; Ahmad, Mahmood; Minhas, Muhammad Usman; Sohail, Muhammad

doi:10.1590/s1984-82502014000300007

Cited by 12 publications

(5 citation statements)

References 26 publications

(30 reference statements)

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“…Drug‐loaded hydrogel discs were assessed for OXP release in 900‐mL solutions at pHs of 1.2 and 7.4 by a USP Dissolution Apparatus‐II at a temperature of 37 ± 0.5 °C. These samples were evaluated at a λ max of 205 nm with UV–visible spectrophotometry (UV‐1601, Shimadzu) …”

Section: Methodsmentioning

confidence: 99%

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Barkat

Ahmad

Minhas

et al. 2017

J of Applied Polymer Sci

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The purpose of this study was to develop and characterize chemically crosslinked chondroitin sulfate-co-poly(methacrylic acid) (CSMA) hydrogels for colon targeting of oxaliplatin (OXP) to treat colorectal cancer. CSMA hydrogels were synthesized by freeradical polymerization. Chondroitin sulfate was chemically crosslinked with methacrylic acid in an aqueous medium. Ammonium peroxodisulfate and N,N-methylene bisacrylamide were used as the initiator and crosslinker, respectively. Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy studies were performed to characterize the fabricated polymeric system. The pH-sensitive characteristics of the hydrogels were evaluated by swelling dynamics and equilibrium swelling ratio measurements at pH 1.2 and 7.4. A toxicity study of the developed formulations was also conducted on rabbits to determine the toxicity of the drug-carrier system to the biological system. The characterization studies confirmed the formation of a new polymeric network. A high OXP loading and higher drug release was observed at pH 7.4. The toxicity study confirmed that the developed formulations were nontoxic to the biological system.

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Section: Methodsmentioning

confidence: 99%

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Barkat

Ahmad

Minhas

et al. 2017

J of Applied Polymer Sci

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“…It is worth mentioning that, when analyzing the Peppas–Sahlin model, which also showed good applicability, the values of K 1 were lower than K 0 , which indicates that the drug release was mainly controlled by Fickian diffusion, together with the contribution of relaxation of the polymer chain, characteristic of transport mechanism case II. A recent study by Khalid and collaborators [ 41 ] showed similar behavior when evaluating the mechanism of release of flurbiprofen-based mucoadhesive tablets.…”

Section: Discussionmentioning

confidence: 67%

“…One of these mechanisms is the production of acidic substances, such as hemolysin, which has higher activity at more acidic pH levels (5.5), Historical data have shown that during the evolutionary stage of T. cruzi the pH of host cells is always below 6.0. In addition, recent studies have shown that the pH of the interior of endosomes and lysosomes ranges between 5.0-6.0 and 4.5-5.0, respectively To prove this fact, the researchers inoculated somewhat more basic solutions (pH 6.2) and measured certain delay in the evolutionary process of the parasite [41][42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

“…The Korsmeyer–Peppas method demonstrated good applicability since ZIF-8 is a coordination polymer matrix. In addition, the value of n = 1.64 corresponds to a super case II transport, suggesting that more than one mechanism may be involved in BNZ release kinetics, referring to the combination of relaxation and erosion followed by diffusion of the drug from the ZIF-8 network, with diffusion being the most significant mechanism [ 31 , 39 – 41 ].…”

Section: Discussionmentioning

confidence: 99%

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Benznidazole in vitro dissolution release from a pH-sensitive drug delivery system using Zif-8 as a carrier

Ferraz

Tabosa

Nascimento

et al. 2021

J Mater Sci: Mater Med

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Chagas disease is a neglected tropical disease caused by the flagellate protozoan Trypanosoma cruzi (T. cruzi). Endemic in underdeveloped and developed countries, due to the migratory movement, it is considered a serious public health problem. Endemic in underdeveloped countries and due to the migratory movement, in developed countries as well, it is considered a serious public health problem. One of the reasons for this is a weak therapeutic arsenal, represented only by the drug benznidazole (BNZ) which, although it promotes significant cure rates in the acute phase of the disease, presents serious problems of toxicity and bioavailability, mainly due to its low aqueous solubility. Several studies have presented several drug delivery systems (DDS) based on BNZ aiming at enhancing its solubility in aqueous medium and, with this, promoting an increase in the dissolution rate and, consequently, in its bioavailability. However, the present work is a pioneer in using a zeolitic imidazolate framework as a carrier agent for a DDS in order to promote a pH-sensitive modulation of the drug. Thus, this work aimed to develop a novel DDS based on BNZ and the ZIF-8 to use it in development of prolonged-release dosage forms to alternative treatment of Chagas disease. The BNZ@ZIF-8 system was obtained through an ex situ method selected due to its higher incorporation efficiency (38%). Different characterization techniques corroborated the obtainment and drug release data were analyzed by in vitro dissolution assay under sink and non-sink conditions and setting the kinetic results through both model dependent and independent methods. Under sink conditions, at pH 4.5, BNZ and BNZ@ZIF-8 showed similar release profile, but the DDS was effective in promoting a prolonged release. At pH 7.6, after 7 h, BNZ showed a lower release than BNZ@ZIF-8. On the other hand, in non-sink conditions at pH 4.5 the BNZ presented 80% of drug release in 3 h, while the DDS in 6 h. At pH 7.6, BNZ presented a release of 80% in 2 h, while the DDS reaches it in only at 12 h. Therefore, at pH 4.5 the DDS BNZ@ZIF-8 showed a faster release with a burst effect, while at pH 7.6 it showed a prolonged and controlled release. Finally, it is evident that a promising DDS pH-sensitive was obtained as a novel carrier that might be able to prolongs BNZ release in dosage forms intended for the alternative treatment of Chagas disease.

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“…Recently buccal mucoadhesive tablets have been developed with promising results. [8][9][10][11][12][13] There are a number of mucoadhesive polymers that many of them are introduced recently. 14,15 But acacia is a natural polymer that has been used for years.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Hydrocortisone Sodium Succinate Mucoadhesive Buccal Tablet

Daneshmehr

Adibpour

Ataie

2020

IJPI

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Background: The present study involves the formulation and in-vitro assessment of mucoadhesive tablets of hydrocortisone sodium succinate. Local treatment for buccal inflammatory injuries such as aphthous wounds relies on the fact that a high amount of drug can be delivered at the target site, as well as reduction or avoidance of steroidal adverse effects seen by systemic administration routes. Methods: Tablets contained acacia as the mucoadhesive component with different concentrations (10, 20 and 30%w/w). To this, lactose, magnesium stearate and active pharmaceutical ingredient were added and mixed thoroughly. These tablets were prepared by direct compression technique. Buccal tablets were tested for thickness, hardness, weight and content uniformity, surface pH and mucoadhesive strength. Kinetic of drug release was also calculated for the best formulation. Dissolution parameters were also measured in-vitro for the selected formulation and compared with Corlan® as the standard reference tablet. Results: All of the tests confirmed the proper formulation according to the standards of conventional oral tablets. Mucoadhesive strength of one of formulations was about 50% more than the reference tablet. The optimized formulation that was made by 10% acacia provided adequate release comparable to Corlan ®. Release profile was best fitted to Hixson-Crowell model. Conclusion: We concluded that our formulated buccal tablet was comparable and similar in-vitro bioequivalent) to the reference tablets.

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Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology

Cited by 12 publications

References 26 publications

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Oxaliplatin‐loaded crosslinked polymeric network of chondroitin sulfate‐co‐poly(methacrylic acid) for colorectal cancer: Its toxicological evaluation

Benznidazole in vitro dissolution release from a pH-sensitive drug delivery system using Zif-8 as a carrier

Formulation and Evaluation of Hydrocortisone Sodium Succinate Mucoadhesive Buccal Tablet

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