Protective effect of guabiju (Myrcianthes pungens (O. Berg) D. Legrand) and red guava (Psidium cattleyanum Sabine) against cisplatin-induced hypercholesterolemia in rats

Nora, C; Danelli, Daiane; Souza, Lucéia Fátima; Rios, Alessandro de Oliveira; Jong, Erna Vogt de; Flôres, Simone Hickmann

doi:10.1590/s1984-82502014000300006

Cited by 19 publications

(7 citation statements)

References 35 publications

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“…These findings exhibit the hepatoprotective potential of plant fraction. Analogous results were observed by Nora et al while experimenting on male rats to inspect the protective effect of guabiju and red guava against CP-induced hypercholesterolemia [ 48 ]. Iliskovic and Singal pointed out that probucol achieved its preventive effect against adriamycin induced cardiomyopathy due to its lipid lowering and antioxidant properties, indicating that lipid lowing property is an important factor in achieving cardio-protective influence [ 47 ].…”

Section: Discussionsupporting

confidence: 76%

Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats

Afsar

Razak

Almajwal

et al. 2017

BMC Complement Altern Med

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BackgroundCisplatin (CP) is recommended as a first-line chemotherapeutic agent for solid tumors, however its usage outcomes in severe adverse effects. Acacia hydaspica possesses various phytochemicals and pharmacological activities. The current study aimed to investigate the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP induced aberrations in lipid profile and hepatotoxicity.MethodsRats were randomly separated into six groups (n = 6). Group 1 (control) received distilled water orally for 21 days. Groups 2 (CP control) received a single dose of CP (7.5 mg/kg bw, i.p) on day 16, group 3 (Plant control) received AHE (400 mg/kg b.w, oral) for 21 days, group 4 (post treated group); CP received on day 16 and AHE (400 mg/kg b.w/day, p.o.) was administered after CP till day 21, Group 5 (pretreated group) received AHE (400 mg/kg b.w/day, p.o.) for 21 days and CP (7.5 mg/kg b.w., i.p.) on day 16, group 6 (Silymarin + CP) received 100 mg/kg b.w., p.o. (11 doses/21 days) and CP (7.5 mg/kg b.w., i.p.) on day 16. Lipid profile, liver functional tests, oxidative stress markers, antioxidant enzymes status and histopathological changes were examined.ResultsThe present study revealed that CP caused body weights loss and increase liver index. CP significantly increased serum total lipid, triglycerides and LDL-cholesterol levels. Conversely, it significantly decreased serum HDL-cholesterol level. CP induced marked deteriorations in serum liver function biomarkers, reduced antioxidant enzymes in tissue, while elevated tissue oxidative stress markers along with morphological injuries compared to control rats. Treatment with AHE ameliorated CP induced alterations in lipid profile, serum ALT, AST, ALP and total bilirubin levels and liver weight. Furthermore AHE treatment improved the total protein and antioxidant enzymes levels while decreased the level of MDA, H2O2, and NO. The altered parameters were returned to the control level with AHE pretreatment. Histopathological analysis also supported the biochemical findings. Pretreatment seems to be more effective compared to post treatment indicating protective effect.ConclusionThese results reveal that treatment of AHE may be useful in the prevention of CP induced hepatotoxicity due to its antioxidant potential and polyphenolic constituents.

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Section: Discussionsupporting

confidence: 76%

Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats

Afsar

Razak

Almajwal

et al. 2017

BMC Complement Altern Med

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“…Its fruits are sweet, round and smooth with 1-cm diameter average, and they have dark purplish color when ripe (Marin et al, 2008). M. pungens leaves have essential oil (Zygadlo et al, 1997;Apel et al, 2006), but they have been little studied, differently from fruits which are edible and present antioxidant activity (Andrade et al, 2011), reduce hypercholesterolemia induced by cisplatin in rats (Nora et al, 2014), and antichemotactic activity (Andrade et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antibacterial activity of Myrcianthes pungens leaf essential oil

Jesus¹,

Oliveira²,

Bortolucci³

et al. 2021

BLACPMA

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Myrcianthes pungens (Myrtaceae) is a native tree to Brazil known as guabijú. In our study, we described the chemical composition of the essential oil from M. pungens dried leaves, the antioxidant activity by different methods and antibacterial activity against Staphylococcus aureus, Bacillus cereus and Pseudomonas aeruginosa. The chemical identification was done by gas chromatograph coupled to mass spectrometer and antibacterial activity was evaluated by broth microdilution method. The leaf essential oil presented hydrocarbon sesquiterpenes (42.6%) as its main chemical class whose major compounds were β-caryophyllene (11.7%) and 1,8-cineole (10.1%). The best antioxidant protection was from 57.5 to 63.3% of β-carotene. The highest antibacterial activity was against S. aureus (MIC of 78.12 µg/mL). This value was 2.56-fold lower than the positive streptomycin control. M. pungens is a promising source of natural molecules with potential study for the development of pharmacological, cosmetic and food products.

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“…The protective effect on hypercholesterolemia in rats observed by Nora et al (2014) is related to the composition of the fruits evaluated. The consumption of a diet rich in fruits and vegetables could be capable of reducing fat levels.…”

Section: Experimental Studiesmentioning

confidence: 86%

“…The protective effect on hypercholesterolemia in rats observed by Nora et al (2014) is related to the composition of the fruits evaluated.…”

Section: Experimental Studiesmentioning

confidence: 99%

Psidium L. genus: A review on its chemical characterization, preclinical and clinical studies

Beltrame

Klein‐Júnior

Schwanz

et al. 2021

Phytotherapy Research

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The Myrtaceae family is considered one of the largest known botanical families and the genus Psidium is among the most economically interesting. Psidium genus comprises approximately 112 species, and it has been extensively studied, mainly because of Psidium guavaja species. Phytochemical investigations confirmed the presence of phenolics as the main compounds, as well as the essential oils, which were also widely investigated. Pharmacological studies report analgesic, anthelminthic, acaricidal, antihiperglicemic, among other biological activities for different species. The present review covers the relevant literature until 2019 and outlines the current data on chemical composition, preclinical and clinical studies on Psidium species, as well as the main possible mechanisms of action responsible for the described activities. Therefore, it can provide a reference for pharmaceutical research and clinical application of this genus.

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Protective effect of guabiju (Myrcianthes pungens (O. Berg) D. Legrand) and red guava (Psidium cattleyanum Sabine) against cisplatin-induced hypercholesterolemia in rats

Cited by 19 publications

References 35 publications

Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats

Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats

Antioxidant and antibacterial activity of Myrcianthes pungens leaf essential oil

Psidium L. genus: A review on its chemical characterization, preclinical and clinical studies

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