Nitric oxide releasing-dendrimers: an overview

Roveda, Antonio C.; Franco, Douglas Wagner

doi:10.1590/s1984-82502013000700002

Cited by 14 publications

(6 citation statements)

References 103 publications

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“…Several lines of evidence have demonstrated the defensive role of NO as a gastroprotective mediator against gastric ulceration through enhancement of mucosal blood flow, stimulation of gastric mucus secretion, and reduction of leukocytic cells' infiltration 59–61. Notwithstanding, upregulation or downregulation of NO can cause deleterious gastric mucosal damage 62,63. The marked effectiveness of the medicated COS-NP s could be assigned to the activity of the drug and the polymer in normalizing the upregulated NO content in ulcerated gastric tissue 10,17…”

Section: Resultsmentioning

confidence: 99%

<p>Novel chitosan oligosaccharide-based nanoparticles for gastric mucosal administration of the phytochemical “apocynin”</p>

Anter

Hashim

Awadin

et al. 2019

IJN

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Background: Apocynin (APO) is a bioactive phytochemical with prominent anti-inflammatory and anti-oxidant activities. Designing a nano-delivery system targeted to potentiate the gastric antiulcerogenic activity of APO has not been investigated yet. Chitosan oligosaccharide (COS) is a low molecular weight chitosan and its oral nanoparticulate system for potentiating the antiulcerogenic activity of the loaded APO has been described here. Methods: COS-nanoparticles (NP s ) loaded with APO (using tripolyphosphate [TPP] as a cross-linker) were prepared by ionic gelation method and fully characterized. The chosen formula was extensively evaluated regarding in vitro release profile, kinetic analysis, and stability at refrigerated and room temperatures. Ultimately, the in vivo antiulcerogenic activity against ketoprofen (KP)-induced gastric ulceration in rats was assessed by macroscopic parameters including Paul’s index and antiulcerogenic activity, histopathological examination, immunohistochemical (IHC) evaluation of cyclooxygenase-2 (COX-2) expression level in ulcerated gastric tissue, and biochemical measurement of oxidative stress markers and nitric oxide (NO) levels. Results: The selected NP s formula with COS (0.5 % w/v) and TPP (0.1% w/v) was the most appropriate one with drug entrapment efficiency percentage of 35.06%, particle size of 436.20 nm, zeta potential of +38.20 mV, and mucoadhesive strength of 51.22%. It exhibited a biphasic in vitro release pattern as well as high stability at refrigerated temperature for a 6-month storage period. APO-loaded COS-NP s provoked marvelous antiulcerogenic activity against KP-induced gastric ulceration in rats compared with free APO treated group, which was emphasized by histopathological, IHC, and biochemical studies. Conclusion: In conclusion, APO-loaded COS-NP s could be considered as a promising oral phytopharmaceutical nanoparticulate system for management of gastric ulceration.

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Section: Resultsmentioning

confidence: 99%

<p>Novel chitosan oligosaccharide-based nanoparticles for gastric mucosal administration of the phytochemical “apocynin”</p>

Anter

Hashim

Awadin

et al. 2019

IJN

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“…The most common dendrimer scaffold that is commercially available is prepared from polyamidoamine (PAMAM) dendrimers [ 152 ]. Dendrimers act as a platform for nitric oxide (NO) transport and delivery, but their application in agriculture is still not explored [ 153 , 154 ]. The usage of dendrimers is widespread, ranging from biology to material sciences [ 155 ].…”

Section: Effects Of Nanomaterials On Seed Germination and Seedlingmentioning

confidence: 99%

Dual Effect of Nanomaterials on Germination and Seedling Growth: Stimulation vs. Phytotoxicity

Szőllősi

Molnár

Kondak

et al. 2020

Plants

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Due to recent active research, a large amount of data has been accumulated regarding the effects of different nanomaterials (mainly metal oxide nanoparticles, carbon nanotubes, chitosan nanoparticles) on different plant species. Most studies have focused on seed germination and early seedling development, presumably due to the simplicity of these experimental systems. Depending mostly on size and concentration, nanomaterials can exert both positive and negative effects on germination and seedling development during normal and stress conditions, thus some research has evaluated the phytotoxic effects of nanomaterials and the physiological and molecular processes behind them, while other works have highlighted the favorable seed priming effects. This review aims to systematize and discuss research data regarding the effect of nanomaterials on germination and seedling growth in order to provide state-of-the-art knowledge about this fast developing research area.

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“…[ 19 ] Due to the short half‐life of NO, NO donors such as S‐nitrosothiols (RSNOs), N‐diazeniumdiolates, organic nitrates, and metal nitrosyl complexes have been developed to allow controlled and localized NO release from biomaterials. [ 20–22 ] The endogenous RSNO S‐nitrosoglutathione (GSNO) is a bioavailable source of NO which has been detected in the body. [ 23 ] GSNO is innately biocompatible, contains spontaneous and tunable NO‐releasing potential, and has superior stability compared to other RSNOs.…”

Section: Introductionmentioning

confidence: 99%

S‐Nitrosoglutathione‐Based Nitric Oxide‐Releasing Nanofibers Exhibit Dual Antimicrobial and Antithrombotic Activity for Biomedical Applications

Douglass

Hopkins

Pandey

et al. 2020

Macromolecular Bioscience

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The novel use of nanofibers as a physical barrier between blood and medical devices has allowed for modifiable, innovative surface coatings on devices ordinarily plagued by thrombosis, delayed healing, and chronic infection. In this study, the nitric oxide (NO) donor S‐nitrosoglutathione (GSNO) is blended with the biodegradable polymers polyhydroxybutyrate (PHB) and polylactic acid (PLA) for the fabrication of hemocompatible, antibacterial nanofibers tailored for blood‐contacting applications. Stress/strain behavior of different concentrations of PHB and PLA is recorded to optimize the mechanical properties of the nanofibers. Nanofibers incorporated with different concentrations of GSNO (10, 15, 20 wt%) are evaluated based on their NO‐releasing kinetics. PLA/PHB + 20 wt% GSNO nanofibers display the greatest NO release over 72 h (0.4–1.5 × 10−10 mol mg−1 min−1). NO‐releasing fibers successfully reduce viable adhered bacterial counts by ≈80% after 24 h of exposure to Staphylococcus aureus. NO‐releasing nanofibers exposed to porcine plasma reduce platelet adhesion by 64.6% compared to control nanofibers. The nanofibers are found noncytotoxic (>95% viability) toward NIH/3T3 mouse fibroblasts, and 4′,6‐diamidino‐2‐phenylindole and phalloidin staining shows that fibroblasts cultured on NO‐releasing fibers have improved cellular adhesion and functionality. Therefore, these novel NO‐releasing nanofibers provide a safe antimicrobial and hemocompatible coating for blood‐contacting medical devices.

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Nitric oxide releasing-dendrimers: an overview

Cited by 14 publications

References 103 publications

<p>Novel chitosan oligosaccharide-based nanoparticles for gastric mucosal administration of the phytochemical “apocynin”</p>

<p>Novel chitosan oligosaccharide-based nanoparticles for gastric mucosal administration of the phytochemical “apocynin”</p>

Dual Effect of Nanomaterials on Germination and Seedling Growth: Stimulation vs. Phytotoxicity

S‐Nitrosoglutathione‐Based Nitric Oxide‐Releasing Nanofibers Exhibit Dual Antimicrobial and Antithrombotic Activity for Biomedical Applications

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