Quercetin: a flavonoid with the potential to treat asthma

Fortunato, Laila Rigolin; Alves, Claudiney de Freitas; Teixeira, Maxelle Martins; Rogério, Alexandre de Paula

doi:10.1590/s1984-82502012000400002

Cited by 30 publications

(15 citation statements)

References 82 publications

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“…Natural products and plant derivatives used in folk medicine are of vast medical importance due to their potential as a source of molecules with pharmacologic properties. Although active plant-derived secondary metabolites can be randomly discovered, the process is laborious, with a success rate on the order of 1 new product per 10,000 plants screened [62, 104]. In this review, we reviewed the effect of some plant extracts and their components on ALI experimental models.…”

Section: Introductionmentioning

confidence: 99%

Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Favarin

Oliveira

et al. 2013

BioMed Research International

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Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and mortality worldwide. ALI is characterized by increased permeability of the alveolar-capillary membrane, edema, uncontrolled neutrophils migration to the lung, and diffuse alveolar damage, leading to acute hypoxemic respiratory failure. Although corticosteroids remain the mainstay of ALI treatment, they cause significant side effects. Agents of natural origin, such as medicinal plants and their secondary metabolites, mainly those with very few side effects, could be excellent alternatives for ALI treatment. Several studies, including our own, have demonstrated that plant extracts and/or secondary metabolites isolated from them reduce most ALI phenotypes in experimental animal models, including neutrophil recruitment to the lung, the production of pro-inflammatory cytokines and chemokines, edema, and vascular permeability. In this review, we summarized these studies and described the anti-inflammatory activity of various plant extracts, such as Ginkgo biloba and Punica granatum, and such secondary metabolites as epigallocatechin-3-gallate and ellagic acid. In addition, we highlight the medical potential of these extracts and plant-derived compounds for treating of ALI.

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Section: Introductionmentioning

confidence: 99%

Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Favarin

Oliveira

et al. 2013

BioMed Research International

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“…However, to exploit KQ as a potential antitumor agent against human cervical carcinoma, future studies are required to focus on the time-dependent effect by human tumor clonogenic assay. Q is widespread in plants, including vegetables and fruits (24). Q is a focus of increased attention of researchers for its potential health benefits and minimal side effects (2).…”

Section: Discussionmentioning

confidence: 99%

Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericumï¿½ascyron L.

Luo

et al. 2018

Oncol Lett

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Abstract. Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer activity compounds from H. ascyron L. and the underlying molecular mechanism. Anticancer activity of H. ascyron L. extract was evaluated using an MTT assay. To confirm the anticancer mechanism of activity compounds, Hoechst 33258, Annexin V-fluorescein isothiocyanate/propidium iodide, 2',7'-dichlorodihydrofluorescein diacetate, rhodamine 123 staining and caspase-3 activity analysis were performed. The results demonstrated that the anti-proliferative action of the mixture of kaempferol 3-O-β-(2"-acetyl) galactopyranoside (K) and quercetin (Q) (molar ratio, 1:1) was significantly increased compared with either of these two compounds separately, and the active fraction of the H. ascyron L. extract |(HALE). HALE, indicating that the anti-proliferative function of H. ascyron L. may be a synergic effect of K and Q. Furthermore, the inhibitory effect of KQ on the growth of HeLa cells was mediated by the induction of apoptosis. To the best of our knowledge, the present study is the first to identify that KQ exhibits significant anti-proliferation activity on HeLa cells via the apoptotic pathway, and is also the first to evaluate the anticancer potential of H. ascyron L. The results of the present study may provide a rational base for the use of H. ascyron L. in the clinic, and shed light on the development of novel anticancer drugs. IntroductionInvasive cervical cancer is one of the most common forms of female malignancies worldwide (1). According to an estimate, in 2008 alone there were ~530,000 novel cases of invasive cervical cancer and ~275,000 cervical cancer-associated mortalities worldwide (1,2). A growing number of young patients suffer from cervical cancer and the pathological types of the malignancies undergo changes (2). Current treatments for cervical cancer include surgery, radiation and chemotherapy, and conventional chemotherapy remains the most common treatment for advanced-stage cancers (3). In the last decade, increasing advances in cancer research have enhanced the understanding of cancer biology and genetics, and anticancer effects may be exhibited through selective cytotoxicity, anti-proliferative action, stimulation of apoptosis and induction of differentiation (4,5).Hypericum ascyron L. (Great St. Johnswort) has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China (6,7). H. ascyron L. extract has been investigated and revealed to exhibit anticancer activities (8,9). H. ascyron L. extract also possesses numerous other beneficial functions, including inhibition of histamine release (10), anti-inflammatory activity, analgesic effects (11), antioxidant activity (11),...

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“…Quercetin is one of the flavonoids which are natural polyphenolic compounds found in numerous components of the human daily diet, including red wine, onions, apples, tea and grapefruit juice 1 . It exerts a broad range of fascinating clinical properties, such as anti-inflammatory 2 , antineoplastic 3 , antimicrobial 4 , antiallergic 5 and antiviral 6 activities. The quercetin is used as a phytogenic additive in chicken feed due to a wide variety of expected beneficial effects on growth performance, oxidation stability, egg and meat quality, immune characteristics and anti-inflammation 7 .…”

Section: Introductionmentioning

confidence: 99%

Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken

Bhutto

Zloh

et al. 2018

Sci Rep

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Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear. Herein, study reports role of quercetin in modulation of P-gp expression and subsequent effects on the pharmacokinetics of enrofloxacin in broilers. Results show that P-gp expression was increased in a dose-dependent manner following exposure to quercetin in Caco-2 cells and tissues of chicken. Absorption rate constant and apparent permeability coefficient of rhodamine 123 were decreased, reflecting efflux function of P-gp in chicken intestine increased by quercetin. Quercetin altered pharmacokinetic of enrofloxacin by decreasing area under curve, peak concentration, and time to reach peak concentration and by increasing clearance rate. Molecular docking shows quercetin can form favorable interactions with binding pocket of chicken xenobiotic receptor (CXR). Results provide convincing evidence that quercetin induced P-gp expression in tissues by possible interaction with CXR, and consequently reducing bioavailability of orally administered enrofloxacin through restricting its intestinal absorption and liver/kidney clearance in broilers. The results can be further extended to guide reasonable use of quercetin to avoid drug-feed interaction occurred with co-administered enrofloxacin or other similar antimicrobials.

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Quercetin: a flavonoid with the potential to treat asthma

Cited by 30 publications

References 82 publications

Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Potential Effects of Medicinal Plants and Secondary Metabolites on Acute Lung Injury

Induction of apoptosis in human cervical carcinoma HeLa cells by active compounds from Hypericumï¿½ascyron L.

Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken

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