Medicinal plants with teratogenic potential: current considerations

Costa, Kassiane Cristine da Silva; Bezerra, Suzana Barbosa; Norte, Clevanice Moreira; Nunes, Luciana Macatrão Nogueira; Olinda, Tiago Moreira de

doi:10.1590/s1984-82502012000300009

Cited by 27 publications

(17 citation statements)

References 30 publications

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“…No previous studies have been conducted for evaluation of teratological disorders associated with this plant. However, numerous investigations have proven the harmful teratogenic effects of some herbal medicines [4,10,14]. Goel et al [15] demonstrated the teratological disorders of Asparagus racemosus (rasayana) involving gross malformation in Charles Foster rats.…”

Section: Discussionmentioning

confidence: 99%

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Teratogenic Effects of Harpagophytum procumbens Ethanolic Extract in Mice and Fetuses

Davari

Miri

Shahraki

2016

Zahedan J Res Med Sci

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Background: Harpagophytum procumbens is a traditional herbal plant belonging to the Pedaliaceae family. This herb is used to treat a wide range of disorders including rheumatism, arthritis, inflammations, gastrointestinal disturbances, hepatic diseases, and anemia. Side effects of this medicinal plant are unknown during pregnancy period. Objectives: Therefore, the objective of the present research was to evaluate the teratogenic effects and congenital malformation resulting from using Harpagophytum procumbens ethanolic extract in pregnant Balb/C mice. Methods: In this experimental study, female mice (N = 40) which had successful mating were kept in standard conditions. Then the ethanolic extract of the plant (200, 400, 600 mg/kg) was given to the treatment groups by gastric gavage route on 0 -14 th days of ges-

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Section: Discussionmentioning

confidence: 99%

“…Care should also be considered for human beings with cardiovascular disorders [1]. Furthermore, herbal medicine products are not free of side effects for pregnant women and fetal abnormality may be developed [10]. To the best of our knowledge, there isn't enough information for embryo toxicity and prenatal effects of DC [5].…”

Section: Introductionmentioning

confidence: 99%

Teratogenic Effects of Harpagophytum procumbens Ethanolic Extract in Mice and Fetuses

Davari

Miri

Shahraki

2016

Zahedan J Res Med Sci

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“…When ingested in large amounts can cause epileptiform seizures and even abortion. Antifertility activity (Ethanolic extract) in rats 13,19,20 Asarum europaeum Linn., Asaroon / Hazelwort: Emmenagogue (menstrual stimulant) not to be used during pregnancy.…”

Section: 11mentioning

confidence: 99%

“…Several study shows that in mice high doses causes changes in the blastocyst formation, reducing the number and delaying the development of embryos during pre-implantation and in another study no significant difference in loss of embryos before implantation between the treated and control groups was noted, but the deaths of fetuses of treated females suggested an embryotoxic effect of R. graveolens. 13,20 Solanum nigrum , Mako/ Kaakamaachi: Solanine present in it is toxic. Dosage: Infusion 15-25 ml, toxic dose of Solanine is 200-400 mg, over dosage causes nausea purging.…”

Section: 16mentioning

confidence: 99%

“…The use of laxatives containing anthraquinones is potentially dangerous, because the ingredients can induce uterine contractions, increase blood flow to the uterus and its attachments; increasing the risk of fetal loss, and may pass into breast milk and cause unwanted effects such as spasms in the infant to be avoided especially in the first trimester. 13,10,20 Cinnamomum camphora Nees & Eberm. Kafoor/ Camphor not be used during pregnancy, camphor given to pregnant rats experienced varied degrees of bleeding and significant structural changes in their uterus, shown to cross the placenta, nursing mother also should avoid using camphor.…”

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Use of Traditional Drugs in Pregnant and Nursing Mothers: A Review of Associated Adverse Drug Reactions

Hamiduddin¹,

Aslam²,

Sofi³

et al. 2016

J. Pharm. Sci. Innov.

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The condition of carrying a developing embryo in the uterus and breast feeding of baby by mothers requires special precautions in term of intake of medicines. Usage of traditional drugs also requires some vigilance in respects of its adverse drugs reactions. The particular dangers of these preparations come rather from the belief that they are natural and therefore necessarily safe in pregnancy. Since last few decades' tremendous research work has been done of the various aspect of medicinal plants on pharmacognostic and chemical aspect, but aspect of safety and toxicity particularly, in pregnancy and lactation, is the most neglected area. These medicines are considering safer then allopathic drugs, but several plant species are proven be toxic in these conditions. For example, volatile oil containing drugs can be abortifacient, Irritant to genitourinary tract (can cause uterine contractions). Some constituents also have got action on uterus. Pyrrolizidine alkaloids can cause Hepatotoxicity in a new born. Some are strong diuretic and laxative (can cause water / salt lose), hormonally active, mutagenic, ginotoxic, teratogenic, etc. So these drugs are better avoided during pregnancy and lactations. An attempt can be made to identify herbal / traditional ingredients that have potential toxic effect on pregnancy and lactating women and also about their potential interfere with specific categories of conventional drugs based on their phytochemical, pharmacological properties and many documented side effects and also due to adulteration by heavy metals & microbial contaminations in relevance with classical Unani & Ayurvedic / traditional literature. Details of these drugs will be discussed in the present work.

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Pregnancy and herbal medicines: An unnecessary risk for women's health—A narrative review

Bruno

Simões

et al. 2018

Phytotherapy Research

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The indiscriminate use of herbal medicines to prevent or to heal diseases or even the use for questionable purposes such as weight loss has received both interest and scrutiny from the scientific community and general public alike. An increasing number of women put their own and the unborn child's health at risk due to a lack of knowledge about the phytochemical properties and adequate use of herbal medicine (phytomedicines or herbal supplements) and lack of communication with their healthcare provider. The purpose of this narrative review was to summarize the use of herbal medicines during pregnancy and their potential toxic effects to highlight the importance of caution when prescribing herbal medicines or supplements for women, because, in addition to suffering interactions and a great amount of information obtained in preclinical predictive studies, assessment of nephrotoxicity, neurotoxicity, hepatotoxicity, genotoxicity, and teratogenicity of traditional medicinal herbs still remains scarce in the clinical setting.

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Medicinal plants with teratogenic potential: current considerations

Cited by 27 publications

References 30 publications

Teratogenic Effects of Harpagophytum procumbens Ethanolic Extract in Mice and Fetuses

Teratogenic Effects of Harpagophytum procumbens Ethanolic Extract in Mice and Fetuses

Use of Traditional Drugs in Pregnant and Nursing Mothers: A Review of Associated Adverse Drug Reactions

Pregnancy and herbal medicines: An unnecessary risk for women's health—A narrative review

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