2012
DOI: 10.1590/s1984-82502012000300007
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Abstract: Antioxidants are currently used as efficient excipients that delay or inhibit the oxidation process of molecules. Excipients are often associated with adverse reactions. Stability studies can guide the search for solutions that minimize or delay the processes of degradation. The ability to predict oxidation reactions in different drugs is important. Methods: This study was conducted to assess the rational use of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), sodium metabisulfite (SMB), propyl … Show more

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Cited by 22 publications
(11 citation statements)
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“…With a relatively lowglass transition temperature value, it was chosen as a model drug in the study. On the one hand, SIM was reported to decompose easily (Celestino, 2012). On the other hand, as stated earlier, the amorphous state is not physicochemically stable compared with its crystalline counterpart (Ahlneck & Waltersson, 1986).…”
Section: Introductionmentioning
confidence: 84%
“…With a relatively lowglass transition temperature value, it was chosen as a model drug in the study. On the one hand, SIM was reported to decompose easily (Celestino, 2012). On the other hand, as stated earlier, the amorphous state is not physicochemically stable compared with its crystalline counterpart (Ahlneck & Waltersson, 1986).…”
Section: Introductionmentioning
confidence: 84%
“…The downside of using antioxidants in oral formulations, however, is that these excipients can be associated with gastric irritation and/or diarrhea [6]. They protect the formulation by sacrificially reacting with oxygen or other reactive species.…”
Section: Excipientsmentioning
confidence: 99%
“…This diversified interest relates to the possible use of these compounds as stabilizers in food, polymer, and fuel industries. Additionally, antioxidants are promising for anticancer and antitumor pharmaceuticals [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Indeed, antioxidants are able to deactivate both typical radical intermediate products and molecular oxidation products, the excessive formation of which can provoke the appearance and development of various pathologies, including cancer, premature aging, diabetes, etc.…”
Section: Introductionmentioning
confidence: 99%