Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon

Abstract

Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy propyl methyl cellulose (K4M), hydroxy propyl methyl cellulose (K15M), sodium carboxy methyl cellulose and poly vinyl pyrolidone (K30), plasticizer poly ethylene glycol (400) and a backing membrane of Eudragit (RL100). The films were evaluated in terms of swelling, residence time, mucoadhesion, release, and organoleptic properties. The optimized films showed lower release as compared to controlled drug delivery systems. Hence, an inclusion complex of acyclovir was prepared with hydrophilic polymer hydroxylpropyl beta-cyclodextrin in the molar ratio of 1:1. The inclusion complex was characterized by optical microscopy, FAB mass spectroscopy, and FTIR spectroscopy. Patches formulated with the acyclovir inclusion complex were evaluated along the same lines as those containing acyclovir alone. The in vitro release data revealed a substantial increase from 64.35% to 88.15% in the case of PS I and PS II batches, respectively, confirming the successful use of inclusion complexes for the formulation of buccal patch of acyclovir.

Combined use of bile acids and aminoacids to improve permeation properties of acyclovir

“…It is expected that the presence of Llys, in addition to the positive effect shown on the acyclovir permeation rate, should contribute also to a beneficial effect in the herpes treatment, due to its reported ability to reduce number and intensity of herpes flare-ups (Kumar and Kumar, 2013;Saxena et al, 2011;Karthik et al, 2011).…”

“…On the contrary, clear differences were observed in the FT-IR spectrum of the coground system. In particular, the main modifications of acyclovir peaks were noticed in the range 1600-1450 cm À1 , where the peak at 1485 cm À1 , due to the aliphatic CÀ ÀH deformation (Kumar and Kumar, 2013) shifted to 1490 and strongly decreased in intensity and the peak at 1575 cm À1 , due to NÀ ÀH bending (Saxena et al, 2011), shifted to 1571 and decreased in intensity. Some further modifications were observed also in the region between 1390 and 1300 cm À1 , particularly evident for the peak at 1309 cm À1 due to CÀ ÀN stretching (Saxena et al, 2011) which markedly decreased in intensity and the peak at 1346 cm À1 attributable to NÀ ÀH stretching (Karthik et al, 2011), which shifted to 1340 cm À1 .…”

An Evaluation of the Binding Strength of Okra Gum and the Drug Release Characteristics of Tablets Prepared from It

“…The values were recorded in triplicate ( n = 3), and the mean was calculated. An almost similar apparatus and method has already been used for measuring mucoadhesive strength in literature [17,18,19]. …”

Development and validation of high-performance liquid chromatography method for simultaneous determination of acyclovir and curcumin in polymeric microparticles

“…When orally administered, ACV presents several limitations, such as low solubility in water, short half-life, and a high rate of renal excretion. Those features compromise ACV bioavailability, which is around 15-30% (Stulzer et al, 2008;Saxena, 2011). Similarly, CUR has low water solubility, compromising its oral usage (Moorthi, 2013b;Tung, 2017).…”