ABSTRACT:The research investigated the modification of nanoemulsion by using transesterfied soyabean oil, to enhanced solubility and diffusion of voriconazole. Ternary phase diagrams of soyabean oil, acid / base esters of soyabean oil, Tween 80: PEG 400 (S/CoS) and water were developed. Ester value of soyabean oil increased from 214.04 to 261.5mg KOH/1g for acid ester and 293.58mg KOH/1g for base ester confirmed transesterification. The modified nanoemulsion batches E 4 , E 5 , E A4 , E A5 , E B2 and E B3 showed thermodynamic stability. Nanoemulsion of Soyabean oil (E 3 and E 4 ), acid ester (E A4 and E A5 ) , and base ester (E B2 and E B3 ) were selected for in-vitro drug diffusion studies. The globule size of batch E 4 , E A4 and E B2 nanoemulsion was found to be 185.6, 162.8 and 115.4 nm, respectively. Zeta potential of batch E 4 , E A4 , and E B2 was observed -35, -27 and -9mV respectively. The in vitro release release profiles from the E 4 , E A4 and E B2 batches of nanoemulsion gel were fitted into Peppas kinetic model. Moreover, "n" value of batch E 4 , E A4 , and E B2 was 0.8844, 0.8284, 0.8475 non-fickian diffusion. The soyabean oil and soyabean acid ester oil nanoemulsion found to be stable and a promising vehicle to enhance the permeation of voriconazole for topical delivery.