Possible pharmacological interactions in hypertensive and/or diabetic elderly in family health units at Blumenau (SC)

Neto, Vicente Codagnone; Garcia, Victor Pundek; Helena, Ernani Tiarajú de Santa

doi:10.1590/s1984-82502010000400022

Cited by 12 publications

(4 citation statements)

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“…Este percentual é comparável ao estudo de Mibielli e colaboradores 4 que incluiu 261 usuários de anti-hipertensivos aposentados e pensionistas com idade superior a 60 anos. O estudo de Bleich e colaboradores 14 4,[14][15][16][17][18] . No presente estudo, as interações moderadas estiveram presentes em 95% dos pacientes que apresentaram pelo menos uma IMP e envolveram, em maior proporção, medicamentos comumente prescritos na atenção básica utilizados para hipertensão e diabetes (inibidores da enzima conversora da angiotensina, diuréticos tiazídicos, diuréticos de alça, diuréticos poupadores de potássio e medicamentos hipoglicemiantes), doenças de maior prevalência.…”

Section: Discussionunclassified

Interações medicamentosas potenciais em adultos e idosos na atenção primária

Santos

Giordani

Rosa

2019

Ciênc. saúde coletiva

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Resumo O objetivo do presente estudo foi caracterizar as interações medicamentosas potenciais (IMP) e avaliar os fatores associados à sua ocorrência em adultos e idosos assistidos pelo Programa Médico de Família de Niterói, Rio de Janeiro. Trata-se de um subestudo do ESTUDO DIGITALIS, que incluiu indivíduos cadastrados no Programa Médico de Família de Niterói (45-99 anos). Foram analisados 341 indivíduos com prescrição de dois ou mais medicamentos. A classificação das IMP seguiu o MICROMEDEX®. Houve 113 interações diferentes. Do total de indivíduos, 63,6% apresentaram pelo menos uma IMP. As variáveis com maior chance de IMP foram: menor escolaridade; renda inferior a R$800,00; ausência de plano de saúde; diagnóstico de hipertensão, diabetes, infarto agudo do miocárdio; e uso de 5 ou mais medicamentos prescritos. Após ajuste, as variáveis diagnóstico anterior de hipertensão e diabetes e uso de 5 ou mais medicamentos prescritos permaneceram significativas estatisticamente. É importante uma gestão cautelosa do tratamento na atenção básica com monitoramento das IMP, especialmente em pacientes mais susceptíveis.

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Section: Discussionunclassified

Interações medicamentosas potenciais em adultos e idosos na atenção primária

Santos

Giordani

Rosa

2019

Ciênc. saúde coletiva

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“…Studies involving community-dwelling individuals report prevalence rates ranging from 4.6 to 17.6% [ 4 , 5 ]. Studies conducted in hospital settings report prevalence rates ranging from 0.6 to 18.3%, and a study carried out in a primary health care unit reports a prevalence rate of 6.8% [ 6 – 8 ]. Janchawee studied the pharmacoepidemiologic of potential drug–drug interactions in the outpatient pharmacy of a university hospital, where the overall rate of potential DDIs was 27.9%, with a maximal value of 57.8% at the Department of Psychiatry.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of drug–drug interactions in geriatric patients at an ambulatory care pharmacy in a tertiary care teaching hospital

Aljadani

Aseeri

2018

BMC Res Notes

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ObjectiveA cross-sectional study was performed from February to May 2015, to estimate the prevalence of drug–drug interactions in geriatric patients at the ambulatory care pharmacy at King Abdul-Aziz Medical City in Jeddah, Saudi Arabia.ResultsA total of 310 patients were included, with a mean age (± SD) of 73.78 ± 6.96, and 48.70% were female. The overall prevalence of DDIs of all categories was 90.64%. Category B DDIs was 55.80%, category C DDIs 87.74%, category D DDIs 51.93%, and category X DDIs 16.45%. Atorvastatine plus omeprazole was identified as the most common interacting pair, with a prevalence of 25.26%. Multivariate logistic regression analysis showed that category D or X DDIs are more likely to occur in the female patient (OR = 1.79; 95% CI 1.07, 2.97), the patient taking more than three medications (OR = 22.62; 95% CI 2.93, 174.83), and the patient with more than two conditions (OR = 3.09; 95% CI 1.81, 5.27).

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“…Studies involving community-dwelling individuals report prevalence rates ranging from 4.6 to 17.6% [20] , [24] . Studies conducted in hospital settings report prevalence rates ranging from 0.6 to 18.3% [23] , [25] – [27] and a study carried out in a primary health care unit reports a prevalence rate of 6.8% [28] . To the best of our knowledge, this is the first large-scale study on primary care carried out in Latin America.…”

Section: Introductionmentioning

confidence: 99%

Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil

et al. 2012

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BackgroundFew cross-sectional studies involving adults and elderly patients with major DDIs have been conducted in the primary care setting. The study aimed to investigate the prevalence of potential drug-drug interactions (DDIs) in patients treated in primary care.Methodology/Principal FindingsA cross-sectional study involving patients aged 45 years or older was conducted at 25 Basic Health Units in the city of Maringá (southern Brazil) from May to December 2010. The data were collected from prescriptions at the pharmacy of the health unit at the time of the delivery of medication to the patient. After delivery, the researcher checked the electronic medical records of the patient. A total of 827 patients were investigated (mean age: 64.1; mean number of medications: 4.4). DDIs were identified in the Micromedex® database. The prevalence of potential DDIs and major DDIs was 63.0% and 12.1%, respectively. In both the univariate and multivariate analyses, the number of drugs prescribed was significantly associated with potential DDIs, with an increasing risk from three to five drugs (OR = 4.74; 95% CI: 2.90–7.73) to six or more drugs (OR = 23.03; 95% CI: 10.42–50.91). Forty drugs accounted for 122 pairs of major DDIs, the most frequent of which involved simvastatin (23.8%), captopril/enalapril (16.4%) and fluoxetine (16.4%).Conclusions/SignificanceThis is the first large-scale study on primary care carried out in Latin America. Based on the findings, the estimated prevalence of potential DDIs was high, whereas clinically significant DDIs occurred in a smaller proportion. Exposing patients to a greater number of prescription drugs, especially three or more, proved to be a significant predictor of DDIs. Prescribers should be more aware of potential DDIs. Future studies should assess potential DDIs in primary care over a longer period of time.

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Possible pharmacological interactions in hypertensive and/or diabetic elderly in family health units at Blumenau (SC)

Cited by 12 publications

References 20 publications

Interações medicamentosas potenciais em adultos e idosos na atenção primária

Interações medicamentosas potenciais em adultos e idosos na atenção primária

Prevalence of drug–drug interactions in geriatric patients at an ambulatory care pharmacy in a tertiary care teaching hospital

Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil

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