Periscelididae (Diptera, Opomyzoidea) are recorded for the first time from French Guiana, with 5 species Marbenia peculiaris Malloch, 1931, Neoscutops barcelosiensis Ale-Rocha & Freitas, 2011, Neoscutops flavoscutellatus Ale-Rocha & Freitas, 2011, Neoscutops peruvianus Hennig, 1969, and Planinasus nigritarsus Mathis & Rung, 2012 found.