Trichostrongylus colubriformis infection in Santa Inês lambs: impact on feed digestibility, blood markers, and nitrogen balance

Silva, Tairon Pannunzio Dias e; Filho, Adibe Luiz Abdalla; Katiki, Luciana Morita; Amarante, Alessandro Francisco Talamini do; Abdalla, Adibe Luiz; Louvandini, Hélder

doi:10.1590/s1984-29612020026

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…However, a common feature of gastrointestinal nematode infections is the reduction in voluntary feed intake, attributed to changes in gastrointestinal motility, impacting food digestion, energy, and nitrogen utilization (Parkins and Holmes 1989 ). In addition, Bompadre et al ( 2023 ) and Dias-Silva et al ( 2020 ) found that the fiber digestibility of infected sheep remained unaffected, despite observing higher CH 4 emissions.…”

Section: Discussionmentioning

confidence: 99%

Interaction between methanotrophy and gastrointestinal nematodes infection on the rumen microbiome of lambs

Corrêa,

Fernandes,

Jimenez

et al. 2024

FEMS Microbiology Ecology

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Complex crosstalk occurs between gastrointestinal nematodes and gut symbiotic microbiota, with consequences for animal metabolism. To investigate the connection between methane production and endoparasites, this study evaluated the effect of mixed infection with Haemonchus contortus and Trichostrongylus colubriformis on methanogenic and methanotrophic community in rumen microbiota of lambs using shotgun metagenomic and Real-time quantitative PCR (qPCR). The rumen content was collected from 6 Santa Inês lambs, (7 months old) before and after 42 days infection by esophageal tube. The metagenomic analysis showed that the infection affected the microbial community structure leading to decreased abundance of methanotrophs bacteria, i.e. α-proteobacteria and β-proteobacteria, anaerobic methanotrophic archaea (ANME), protozoa, sulfate-reducing bacteria, syntrophic bacteria with methanogens, geobacter, and genes related to pyruvate, fatty acid, nitrogen, and sulfur metabolisms, ribulose monophosphate cycle and Entner-Doudoroff Pathway. Additionally, the abundance of methanogenic archaea and the mcrA gene did not change. The co-occurrence networks enabled us to identify the interactions between each taxon in microbial communities and to determine the reshaping of rumen microbiome associations by gastrointestinal nematode infection. Besides, the correlation between ANMEs was lower in the animal's post-infection. Our findings suggest that gastrointestinal parasites potentially lead to decreased methanotrophic metabolism-related microorganisms and genes.

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Section: Discussionmentioning

confidence: 99%

Interaction between methanotrophy and gastrointestinal nematodes infection on the rumen microbiome of lambs

Corrêa,

Fernandes,

Jimenez

et al. 2024

FEMS Microbiology Ecology

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“…Both nematode species have been implicated in such changes. In lambs, the main deleterious effect of parasitism by H. contortus is anemia (Carvalho et al, 2015), whereas in the case of parasitism by T. colubriformis the main deleterious effects are due to immunopathological changes to the small intestine mucosa (Cardia et al, 2011;Dias-Silva et al, 2020). The losses of endogenous proteins result in a net loss of amino acids, along with an imbalance in energy and mineral metabolism (van Houtert & Sykes, 1996).…”

Section: Discussionmentioning

confidence: 99%

Performance of lambs under four levels of dietary supplementation and artificially mix-infected with Haemonchus contortus and Trichostrongylus colubriformis

Carvalho

Neves

Pennacchi

et al. 2021

Rev. Bras. Parasitol. Vet.

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The effect of four diets on the performance of Dorper lambs that were artificially mix-infected with 1000 infective larvae (L3) of Haemonchus contortus and 1000 L3 of Trichostrongylus colubriformis every three days for 12 weeks was evaluated. For each diet, one infected group (n = 7) and one control group (n = 4) were set up. The four diets contained the following proportions of hay (H) and concentrate (C): Diet 1 - 100%H; Diet 2 - 75%H:25%C; Diet 3 - 50%H:50%C; Diet 4 - 25%H:75. All the infected groups showed decreases in mean packed cell volume (PCV) and total plasma protein, especially the Diet 1-infected, which was also the group with the highest fecal egg count. The diets and infection had significant effects (P < 0.05) on daily body weight gain (DBWG), cold carcass weight and daily food consumption. The control and infected groups had mean DBWG (in kg), respectively, of 0.048 and 0.025 with Diet 1; 0.082 and 0.067 with Diet 2; 0.188 and 0.189 with Diet 3; and 0.303 and 0.221 with Diet 4. In conclusion, the infection affected the productive performance regardless of the diet; however, with increased metabolizable protein and energy, the risk of occurrence of anemia and hypoproteinemia diminished.

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“…The formation of tunnels by T . colubriformis in epithelium mucosa affects tissue integrity, provoking hyperplasia and crypt hypertrophy, atrophy of microvillus and epithelium erosion (Cardia et al ., 2011; Dimitrijević et al ., 2012), and thus compromising retention time of digesta, and the digestibility and absorption of nutrients (Cardia et al ., 2011; Dias-Silva et al ., 2019, 2020). Furthermore, it may lead to decreased feed intake due to inappetence (Kyriazakis et al ., 1996; Coop & Kyriazakis, 1999; Dias-Silva et al ., 2021).…”

Section: Introductionmentioning

confidence: 99%

Influence of breed and parasite challenge on the immune response to naturally acquired intestinal nematode infection in sheep

et al. 2022

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Natural infection by intestinal nematodes was assessed in Santa Ines and Ile de France sheep breeds, over a five-month grazing period, with emphasis on the development of the immune response in lambs under two anthelmintic treatment regimens. Nineteen Santa Ines and 19 Ile de France male lambs were allocated into two treatment groups: animals under suppressive treatment with anthelmintics; and animals under targeted selective treatment (TST). The nematodes Trichostrongylus colubriformis and Strongyloides papillosus showed the highest infection intensity in the TST animals in both breeds. Parasite-specific immunoglobulin G levels were significantly higher and more rapidly induced in Santa Ines lambs. Additionally, these lambs had higher levels of parasite-specific immunoglobulin A in intestinal mucus. Animals under TST had higher means of mast cells and globule leukocytes in the intestinal mucosa due to longer and greater parasite challenge in comparison with the suppressive group. A breed effect (P < 0.05) was recorded for mast cells, with Santa Ines lambs presenting the highest counts. Although Santa Ines lambs had lower intestinal nematode counts than Ile de France lambs, they had shown a large variation in T. colubriformis burden, with most of them presenting a marked worm burden, despite showing an earlier and more intense immune response to intestinal nematode infection.

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Trichostrongylus colubriformis infection in Santa Inês lambs: impact on feed digestibility, blood markers, and nitrogen balance

Cited by 6 publications

References 18 publications

Interaction between methanotrophy and gastrointestinal nematodes infection on the rumen microbiome of lambs

Interaction between methanotrophy and gastrointestinal nematodes infection on the rumen microbiome of lambs

Performance of lambs under four levels of dietary supplementation and artificially mix-infected with Haemonchus contortus and Trichostrongylus colubriformis

Influence of breed and parasite challenge on the immune response to naturally acquired intestinal nematode infection in sheep

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