Implication of the fecal egg count reduction test (FECRT) in sheep for better use of available drugs

Salgado, Jordana Andrioli; Cruz, Letícia Vidal; Rocha, Letícia Oliveira da; Sotomaior, Cristina Santos; Borges, Tâmara Duarte; Santos, Clóvis de Paula

doi:10.1590/s1984-29612019093

Cited by 8 publications

(6 citation statements)

References 39 publications

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“…The reason is because the cattle owner feared that the animals would continue to be parasitized; because of this, the effectiveness was calculated with the formula reported by [15]. [18] mentioned that control of F. hepatica and GIN infections requires a deep understanding of parasite epidemiology and of the production system. It is also of paramount importance to preserve the effectiveness of compounds [19].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Fasciolicidal/Nematicidal Efficacy of an Intramuscular Combination of Clorsulon/Levamisole in Naturally Infected Dairy Cattle

Ibarra-Velarde¹,

Vera‐Montenegro²,

Olave-Leiva³

et al. 2022

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The aim of the present study was to assess the fasciolicidal and nematicidal efficacy of a new combination of clorsulon/levamisole, which was formulated for intramuscular administration, in dairy cattle. For the study, sixteen Holstein-Freisian dairy cows were selected for inclusion in the trial based on finding Fasciola hepatica eggs or gastrointestinal nematodes (GIN) in the feces. Ten of these cows were naturally infected with F. hepatica, and 6 were naturally infected with GIN. On Day 0 (zero), all animals were treated with a combination of clorsulon (2.5 mg/kg/IM and levamisole (2.5 mg/kg/IM) administered at the dose recommended by the manufacturer (1 ml/20kg/bw). Subsequently, their feces were analyzed on days 0, 7, 14 and 21 post treatments by the Flukefinder sedimentation method and McMaster technique to determine the percentages of egg reduction in the animals, with reference to the egg load count on day 0. The results obtained in the current work indicated an efficacy of 100% that was determined by the percentage reduction of eggs of F. hepatica and/or GIN. This new fasciolicide/nematicide formulation exerted a remarkable effect and can be considered a new alternative to control F. hepatica and gastrointestinal worms in dairy cattle.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the Fasciolicidal/Nematicidal Efficacy of an Intramuscular Combination of Clorsulon/Levamisole in Naturally Infected Dairy Cattle

Ibarra-Velarde¹,

Vera‐Montenegro²,

Olave-Leiva³

et al. 2022

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“…Diagnosis of anthelmintic resistance in sheep since Salgado et al (2019) had reported that multiple anthelmintic resistance is a serious problem within sheep production in Brazil.…”

Section: /10mentioning

confidence: 99%

Anthelmintic resistance of Haemonchus contortus from sheep flocks in Brazil: concordance of in vivo and in vitro (RESISTA-Test©) methods

Gaínza

Santos

Figueiredo

et al. 2021

Rev. Bras. Parasitol. Vet.

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This study evaluated the resistance status of Haemonchus contortus from sheep flocks in the state of São Paulo, Brazil, through comparison between the fecal egg count reduction test (FECRT) and the larval development test (LDT). For the FECRT, 35 sheep were selected in each of five flocks and divided into groups treated with: benzimidazole, levamisole, ivermectin, monepantel and control. Feces were collected for EPG and fecal cultures. The LDT was performed using thiabendazole (TBZ), levamisole (LEV), ivermectin aglycone (IVM-A) and Zolvix (ZLV). Resistance to all drugs was detected using FECRT in 100% of the flocks, except in relation to ZLV (40% resistant and 20% suspected of resistance). LDT indicated resistance to TBZ and IVM-A in all flocks, to LEV in 80% of flocks and to ZLV in 10%. Total agreement was obtained between the two tests for TBZ and IVM (k = 1.0), while for LEV (k = 0.8) and ZLV (k = 0.9), substantial and almost perfect agreement were obtained, respectively. The concordance between the tests was significant, thus showing that it is possible to use the outcome of the LDT to predict the FECRT, and hence validating the former as a fast diagnostic test for use by sheep farmers in Brazil.

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“…Nevertheless, narrow-spectrum anthelimintics appear to be a better choice if they are used with absolute care. An alternate approach is to carry out 'faecal egg count reduction test' (FECRT) before choosing an anthelimintic (Salgado et al 2019). However, an even better, time-saving, economical, and standard strategy is to carry out DNA-based testing regionally to identify resistant strains of H. contortus against a range of drugs (Ehrenreich et al 2012).…”

Section: Treatmentmentioning

confidence: 99%

Ovine haemonchosis: a review

Naeem

Zahid²,

Roohi

2020

Trop Anim Health Prod

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Sheep farming is the backbone of a rural economy in developing countries, and haemonchosis is a major impediment in the way of its progress. Haemonchus contortus (H. contortus) infection persists all over the world particularly in the tropical and subtropical regions. Various review articles have been published to substantially cover one or more aspects of its morphology, prevalence, pathogenesis, symptoms, diagnosis, immune response, drug resistance, treatment, and control measure. The objective of this paper is to briefly review past and present information available in the aforementioned areas in one place to enable the readers to fully understand the problem from a broader perspective. H. contortus parasite harbours in abomasum of affected animal and feeds on its blood, producing mild to severe symptoms and even death in acute form. The parasite thus inflicts heavy production losses and is of economic importance. H. contortus has developed diverse characters over the years leading to limited success in the production of vaccines. Indiscriminate use of the anthelmintics has produced drug resistance against almost all conventional products. Efficacy of medicinal plants and non-conventional chemicals has been reported under controlled experiments; however, research on their adverse effects on growth and fertility is yet to be studied. Research on molecular tools for identification and introduction of resistant genes into the flock is also underway but still a long journey to find its field application. Crossbreeding may compromise the production traits of the existing flock. In given circumstances, a targeted selective treatment approach along with selective breeding, culling of more susceptible animals, and maintaining a good body condition score through the provision of a balanced diet remains a workable strategy to control haemonchosis in sheep.

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Implication of the fecal egg count reduction test (FECRT) in sheep for better use of available drugs

Cited by 8 publications

References 39 publications

Evaluation of the Fasciolicidal/Nematicidal Efficacy of an Intramuscular Combination of Clorsulon/Levamisole in Naturally Infected Dairy Cattle

Evaluation of the Fasciolicidal/Nematicidal Efficacy of an Intramuscular Combination of Clorsulon/Levamisole in Naturally Infected Dairy Cattle

Anthelmintic resistance of Haemonchus contortus from sheep flocks in Brazil: concordance of in vivo and in vitro (RESISTA-Test©) methods

Ovine haemonchosis: a review

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