The potential of plant and fungal proteins in the control of gastrointestinal nematodes from animals

Abstract

Gastrointestinal nematode infection is an important cause of high economic losses in livestock production. Nematode control based on a synthetic chemical approach is considered unsustainable due to the increasing incidence of anthelmintic resistance. Control alternatives such as the use of natural products are therefore becoming relevant from an environmental and economic point of view. Proteins are macromolecules with various properties that can be obtained from a wide range of organisms, including plants and fungi. Proteins belonging to different classes have shown great potential for the control of nematodes. The action of proteins can occur at specific stages of the nematode life cycle, depending on the composition of the external layers of the nematode body and the active site of the protein. Advances in biotechnology have resulted in the emergence of numerous protein and peptide therapeutics; however, few have been discussed with a focus on the control of animal nematodes. Here, we discuss the use of exogenous proteins and peptides in the control of gastrointestinal.

Beneficial Properties of Bromelain

“…The growing resistance of nematodes to commercially available drugs demand the development of new, alternative treatment methods. Recently, an increase in interest in compounds of plant origin has been observed [88].…”

Low-Molecular-Weight Secondary Metabolites from Fungi: Cerrena unicolor as a New Proposal of an Effective Preparation against Rhabditis Nematodes

“…The antibacterial, antiviral, antioxidant, or antitumor effects of plant and fungal substances are widely known. Many of them are also used to treat human and animal gastrointestinal diseases caused by parasites [ 1 , 12 , 13 , 14 , 15 , 16 ].…”

“…Many active substances have also been isolated from wood degrading mushroom species. One of the efficient sources of multiple bioactive compounds is the white rot fungus C. unicolor ( Table 1 ) [ 12 , 15 , 24 ]. During their growth, white rot fungi produce large amounts of side products during the synthesis of enzymes, for instance, laccase, in the liquid culture medium.…”

Tropical plants as alternative anthelmintics against Cotylophoran cotylophorum of sheep

“…Free amino acids shortened lifespan even more than proteins in sterile ants (Arganda et al 2017). Though non-protein based low molecular weight compounds have dominated the study of natural products, proteins produced by plants play a crucial role in defence against pathogens (Soares et al 2019).…”