Efficacy of treatments with toltrazuril 7.5% and lasalocid sodium in sheep naturally infected with Eimeria spp.

Abstract

The objective of this study was to evaluate the efficacy of an experimental formulation of toltrazuril 7.5% + Trimix™ on a naturally acquired infection of Eimeria spp. in suckling lambs kept on pasture and, in another trial, evaluate the comparative efficacy between lasalocid and toltrazuril 7.5% + Trimix™ in newly weaned sheep under feedlot conditions that had been naturally infected with Eimeria spp. In the first experiment, 30 suckling lambs were divided into two groups: A - treated with toltrazuril 7.5% + Trimix™ and B- control. In experiment 2, 30 weaned sheep were divided into three groups: I - treated with toltrazuril 7.5% + Trimix™, II - treated with lasalocid and III - control. Treatment group A showed an efficacy of 90, 99.4 and 87.3% on days 5, 10 and 20, respectively. Treatment group I had an efficacy of 98.2, 92.6 and 94.5%, while group II had an efficacy of 72.7, 81.6 and 95.9% on days 7, 21 and 42, respectively. Eight Eimeria species were identified; E. ovinoidalis was the most common. Treatment with the toltrazuril 7.5% +Trimix ™ formulation was effective against Eimeria spp. in suckling lambs in field conditions and lambs weaned in under feedlot conditions.

Evaluation of methylene blue, pyrimethamine and its combination on anin vitro Neospora caninummodel

“…The price of MB (catalogue number M9140) and Pyr (catalogue number 46706) at Sigma-Aldrich website is USD 0·0027 and USD 0·21 per milligram, respectively. MB and Pyr appears as competitive treatment candidates, when compared, for example, to toltrazuril (USD 0·31 per milligram; catalogue number 34000), currently applied against animal coccidiosis (Philippe et al 2014; Rodrigues Fde et al 2016). The price from Sigma usually represents several aspects such as costs for synthesis or extraction and purification, essential factors when scaling up for clinical purposes.…”