Resistance exercise improves metabolic parameters and changes adipocyte-derived leptin: a comparison between genders in untrained adults

Abstract

This study examined gender differences after resistance exercise (RE) by measuring fasting plasma levels of creatine kinase, lipid profile, blood glucose, adiponectin, tumor necrosis factor alpha (TNF-α), and leptin. Thirteen women (23.6 ± 7.3 years) and 11 men (29.5 ± 9 years) were enrolled in the study. Two bouts of RE were performed on two different occasions separated by 48 h each. Blood samples were collected and analyzed at baseline and 15 h after the last RE session. Increased creatine kinase levels and improvements in lipid profile and blood glucose were found for both genders. No changes in adiponectin and TNF-α levels were observed for both genders, but leptin levels were reduced (p < 0.05) only for women after RE. Collectively, our findings clearly show that RE was effective in lowering blood glucose and that this effect was not accompanied by changes in adiponectin levels in healthy subjects, indicating that RE is still an important tool for the prevention of metabolic diseases. Furthermore, two sessions of RE promoted a reduction in leptin levels in women, even though no changes in body weight were found, showing that RE is an interesting approach to study obese patients and metabolic regulation.

Effects of 12 Weeks of Resistance Training on Cardiovascular Risk Factors in School Adolescents

“…In general, for dyslipidemia, some studies suggest that the reduction in triglyceride blood concentration maintains a relationship that is inversely proportional to the increase in promoted muscle mass induced by resistance exercise training [28][29][30][31][32][33]. This does not rule out the possibility that this also occurred with adolescents who underwent our 12-week RTP.…”

“…Adult subjects undergoing resistance training lasting an average of 8 to 16 weeks, as evidenced by Tibana and Prestes [37], show a reduction in Cholesterol, Triglycerides, LDL and Blood Glucose values [28][29][30]. According to these authors, these changes result from the influence of resistance training on the increase in serum LDL receptor volume, which promotes the plasma reduction of circulating LDL levels [29].…”

“…The reduction in blood glucose values after 12 weeks of training may be explained by the fact that RTP is able to promote the activation of three possible mechanisms: improved insulin-independent glucose uptake [26]; improved glucose uptake by promoting positive adjustments on the signaling pathway of this hormone [27]; and/or their association (improvement of insulin dependent and independent pathways) [28,29]. Unfortunately, these hypotheses cannot be evaluated in the study groups due to the scarcity of collected samples and the fact that biopsies are difficult to obtain.…”

“…The values represented by the non-HDL variables are expressed as the sum of other biochemical variables, including LDL, VLDL and intermediate density lipoprotein (IDL). Such variables have been pointed out as strong indicators of dyslipidemia and cardiovascular risk when associated with other lipoproteins [29][30][31][32].…”

Lepti̇n Ve Adi̇ponekti̇ni̇n Enerji̇ Ve Egzersi̇z İli̇şki̇si̇

“…Obez kadınlarda dört haftalık yürüyüş egzersizinden sonra insülin direnci ve leptin seviyesinde azalma meydana geldiği bildirilmiştir [39]. Başka bir benzer çalışma ise Mota ve ark, tarafından hem erkek hem de kadınlar üzerinde yapılmış ve ağır egzersizlerde leptin seviyesinde düşüş meydana geldiği bildirilmiştir [51].…”