Prevalence of frontotemporal dementia in community-based studies in Latin America: A systematic review

Custodio, Nilton; Herrera-Pérez, Eder; Lira, David; Montesinos, Rosa; Bendezú, Liliana

doi:10.1590/s1980-57642013dn70100005

Cited by 21 publications

(22 citation statements)

References 36 publications

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“…Community-based studies conducted in LA with individuals aged ≥55 years have found that the prevalence of FTD ranges from 12 to 18 cases per 1000 people, and that it is higher among Brazilians (2.6%–2.8%; Herrera et al, 2002 ; Lopes, 2006 ) than among Peruvians (1.90%; Custodio et al, 2008 ) and Venezuelans (1.53%; Maestre et al, 2002 ; Table 2 ). The values reported are intermediate with respect to global studies (Custodio et al, 2013 ). In general, the exact prevalence of FTD is unknown.…”

Section: The Prevalence Of Dementia In Latin Americacontrasting

confidence: 77%

Dementia in Latin America: Epidemiological Evidence and Implications for Public Policy

Custodio

Wheelock

Thumala

et al. 2017

Front. Aging Neurosci.

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Population aging is among the most important global transformations. Today, 12% of the world population is of age 60 and over and by the middle of this century this segment will represent 21.5%. The increase in population of those aged 80 and over, also referred to as the “oldest old” or the “very elderly”, will be even more pronounced, going from 1.7% of the population to 4.5% within the same period. Compared to European and North American countries, Latin America (LA) is experiencing this unprecedented demographic change at a significantly faster rate. Due to demographic and health transitions, the number of people with dementia will rise from 7.8 million in 2013 to over 27 million by 2050. Nowadays, the global prevalence of dementia in LA has reached 7.1%, with Alzheimer’s Disease (AD) being the most frequent type. This level is similar to those found in developed countries; however, the dementia rate is twice as high as that of the 65–69 years age group in developed countries. In addition, the prevalence and incidence of dementia is higher among illiterate people. Mortality rates due to dementia have risen considerably. The burden and costs of the disease are high and must be covered by patients’ families. The prevention of dementia and the development of long-term care policies and plans for people with dementia in LA, which take into account regional differences and similarities, should be urgent priorities.

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Section: The Prevalence Of Dementia In Latin Americacontrasting

confidence: 77%

Dementia in Latin America: Epidemiological Evidence and Implications for Public Policy

Custodio

Wheelock

Thumala

et al. 2017

Front. Aging Neurosci.

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121

118

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“…Most of the literature available on the epidemiology of dementia comes from North American and European cohorts. The most extensive studies on the prevalence of dementia in LAC countries identified frequency rates similar to those reported by western and eastern countries ( 11 – 13 ). Among neurodegenerative dementia, Alzheimer's disease dementia (ADD) and Lewy body dementia are the leading cause of dementia, following by Frontotemporal dementia (FTD), the third most common form of dementia across all age groups, after, and is a leading cause of early-onset dementia ( 14 , 15 ), with a prevalence ranging from 3 to 26% described in North America and European populations ( 16 , 17 ).…”

Section: Introductionsupporting

confidence: 60%

Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries

et al. 2021

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Frontotemporal dementia (FTD) includes a group of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders, affecting the fronto-insular-temporal regions of the brain. Clinically, FTD is characterized by progressive deficits in behavior, executive function, and language and its diagnosis relies mainly on the clinical expertise of the physician/consensus group and the use of neuropsychological tests and/or structural/functional neuroimaging, depending on local availability. The modest correlation between clinical findings and FTD neuropathology makes the diagnosis difficult using clinical criteria and often leads to underdiagnosis or misdiagnosis, primarily due to lack of recognition or awareness of FTD as a disease and symptom overlap with psychiatric disorders. Despite advances in understanding the underlying neuropathology of FTD, accurate and sensitive diagnosis for this disease is still lacking. One of the major challenges is to improve diagnosis in FTD patients as early as possible. In this context, biomarkers have emerged as useful methods to provide and/or complement clinical diagnosis for this complex syndrome, although more evidence is needed to incorporate most of them into clinical practice. However, most biomarker studies have been performed using North American or European populations, with little representation of the Latin American and the Caribbean (LAC) region. In the LAC region, there are additional challenges, particularly the lack of awareness and knowledge about FTD, even in specialists. Also, LAC genetic heritage and cultures are complex, and both likely influence clinical presentations and may modify baseline biomarker levels. Even more, due to diagnostic delay, the clinical presentation might be further complicated by both neurological and psychiatric comorbidity, such as vascular brain damage, substance abuse, mood disorders, among others. This systematic review provides a brief update and an overview of the current knowledge on genetic, neuroimaging, and fluid biomarkers for FTD in LAC countries. Our review highlights the need for extensive research on biomarkers in FTD in LAC to contribute to a more comprehensive understanding of the disease and its associated biomarkers. Dementia research is certainly reduced in the LAC region, highlighting an urgent need for harmonized, innovative, and cross-regional studies with a global perspective across multiple areas of dementia knowledge.

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“…Además, a diferencia de los países desarrollados los costos son originados predominantemente por los costos de los cuidados informales 1 , los costos médicos representan un pequeño porcentaje y los costos cubiertos por el sistema de salud son inexistentes 1,6 . En nuestro país, la demencia más frecuente en individuos mayores de 65 años es la enfermedad de Alzheimer (EA) (56,3%) 7 ; mientras que demencia frontotemporal (DFT) alcanza solamente el 1,90% 7,8 .…”

Section: Introductionunclassified

Nivel de conocimientos sobre demencia frontotemporal en una muestra de médicos que evalúan regularmente a pacientes con demencia en Lima-Perú

Custodio

Becerra-Becerra

Cruzado

et al. 2018

Rev. chil. neuro-psiquiatr.

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Physicians with specialty in geriatrics, psychiatry and neurology have not received training about the differential diagnosis of dementia, particularly regarding fronto-temporal dementia (FTD). Objective: To assess the level of knowledge of physicians about FTD. Material and Method: The survey was carried out during symposiums and scientific congresses from January 2016 to July 2017. Inclusion criteria: being a general practitioner or specialist in Geriatrics, Neurology and psychiatry whose training process as a physician and specialist has been carried out in Peruvian universities. We analyzed 217 surveys of which 13 were eliminated. The survey was divided into three parts, the first about general data of doctors, the second part was about the diagnosis of dementia; and the third on specific data of FTD. STATA version 12 was used for the statistical analysis. Results: 90% of the doctors surveyed were specialists in: Psychiatry (41.3%), Geriatrics artículo de investigación Recibido: 14/01/2017 Aceptado: 28/03/2018 Los autores no presentan ningún tipo de conflicto de interés. Financiamiento: El trabajo fue financiado por los autores.

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Prevalence of frontotemporal dementia in community-based studies in Latin America: A systematic review

Cited by 21 publications

References 36 publications

Dementia in Latin America: Epidemiological Evidence and Implications for Public Policy

Dementia in Latin America: Epidemiological Evidence and Implications for Public Policy

Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries

Nivel de conocimientos sobre demencia frontotemporal en una muestra de médicos que evalúan regularmente a pacientes con demencia en Lima-Perú

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