Systematic review of the literature on vitamin A and memory

Fragoso, Yára Dadalti; Campos, Niklas Söderberg; Tenrreiro, Breno Faria; Guillen, Fernanda Jussio

doi:10.1590/s1980-57642012dn06040005

Cited by 9 publications

(5 citation statements)

References 55 publications

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“…Different alterations of the regional distribution of 99m Tc-HMPAO retention have been reported in depressed patients [61]. Many clinical studies showed that 13-RA causes stress manifested by somatic intracranial hypertension, cerebral infarction, cerebral or thrombotic hemorrhage [62, 63], encephalopathy [64], brain blood vessel inflammation [65], and neurodegenerative disorders [66].…”

Section: Discussionmentioning

confidence: 99%

13-cis-Retinoic Acid Affects Brain Perfusion and Function: In Vivo Study

Al-Saeedi

Rajendran

2023

Mol Imaging

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Purpose. Study the effects of 13-cis-retinoic acid (13-RA), a synthetic analogue of a vitamin A used for the treatment of severe acne, on the blood flow in the rat brain using technetium-99m hexamethyl propylene amine oxime (99mTc-HMPAO) imaging. Methods. A total of 30 adult male Wistar rats were divided into the control (C), low-dose (L), and high-dose (H) groups. The L and H rats were exposed subcutaneously to 0.3 and 0.5 mg, respectively, of 13-RA per kg of body weight for seven days. Brain blood flow imaging was performed using a gamma camera. Then, a region of interest (ROI) around the brain (target, T), a whole-body region (WB), and a background region (BG) was selected and delimited. The net 99mTc-HMPAO brain counts were calculated as the net target counts, NTC = T − BG / WB − BG in all groups. At the end of the 99mTc-HMPAO brain blood flow imaging, the brain, heart, kidney, lung, and liver were rapidly removed, and their uptake was determined. Brain histopathological analysis was performed using hematoxylin and eosin stains. In addition, the plasma fatty acids were studied using gas chromatography/mass spectrometry. Results. There were highly significant differences between L and H in comparison to C and across the groups. The 99mTc-HMPAO radioactivity in the brain showed increased uptake in a dose-dependent manner. There were also significant changes in the brain tissues and decreased free fatty acids among the groups compared to C. Conclusion. 13-RA increases 99mTcHMPAO brain perfusion, uptake, and function and reduces fatty acids.

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Section: Discussionmentioning

confidence: 99%

13-cis-Retinoic Acid Affects Brain Perfusion and Function: In Vivo Study

Al-Saeedi

Rajendran

2023

Mol Imaging

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“…In this study, a systematic review of the literature was conducted according to the guidelines set forth in the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. 20 The search and review of studies, carried out from September to October 2020, was performed on the SciELO, LILACS, PubMed, and Medline databases.…”

Section: Methodsmentioning

confidence: 99%

“…Using the PICo (Population, Interest and Context) framework, 20 the following research question was defined: Can educational and cognitive interventions promote improvement in psychological well-being, mood, and QoL of older adults with MCI and those with depressive symptoms? The population refers to the mature and older adults without dementia and/or with MCI, the interest refers to the psychological well-being and QoL, and context refers to educational and cognitive intervention, including memory training and cognitive stimulation.…”

Section: Methodsmentioning

confidence: 99%

Cognitive interventions in mature and older adults, benefits for psychological well-being and quality of life: a systematic review study

Lima-Silva¹,

Santos²,

Moreira³

et al. 2021

Dement. neuropsychol.

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Few recently published studies investigating the benefits of educational and cognitive interventions on quality of life (QoL), psychological well-being, and depressive symptoms are available. Objective: The aim of this study was to investigate the effects of educational and cognitive interventions on psychological well-being, QoL, and mood in mature and older adults without dementia and/or with mild cognitive impairment (MCI). Methods: The systematic review took place from September to October 2020 and the following databases were used to select the studies: SciELO, LILACS, PubMed, and Medline. The search terms used were idos* AND “treino cognitivo” AND “bem-estar psicológico” AND “qualidade de vida” and their corresponding translations in English and Spanish. Results: Of the 241 articles retrieved, 26 primary studies were included in the review. Of these, 18 showed improvement in QoL, psychological well-being, or cognition. Conclusions: The studies reported beneficial effects of educational and cognitive interventions for QoL, psychological well-being, and depressive symptoms of mature and older adults without dementia or depression.

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“…Vitamin A can easily enter the brain and become transformed into its bioactive forms. Retinoic acid, the active form of vitamin A, is a powerful signaling molecule in the brain [146,147]. It controls the expression of many genes and influences the growth of new neurons, the survival of existing neurons, and the ability of neurons to change and adapt [147].…”

Section: Vitamin Amentioning

confidence: 99%

A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer’s Disease: A Focus on Probiotic and Vitamin Co-Supplementation

Sultana,

Hia,

Reddy

2024

Antioxidants

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Alzheimer’s disease is a progressive neurodegenerative disorder with a complex etiology, and effective interventions to prevent or delay its onset remain a global health challenge. In recent years, there has been growing interest in the potential role of probiotic and vitamin supplementation as complementary strategies for Alzheimer’s disease prevention. This review paper explores the current scientific literature on the use of probiotics and vitamins, particularly vitamin A, D, E, K, and B-complex vitamins, in the context of Alzheimer’s disease prevention and management. We delve into the mechanisms through which probiotics may modulate gut–brain interactions and neuroinflammation while vitamins play crucial roles in neuronal health and cognitive function. The paper also examines the collective impact of this combinational therapy on reducing the risk factors associated with Alzheimer’s disease, such as oxidative stress, inflammation, and gut dysbiosis. By providing a comprehensive overview of the existing evidence and potential mechanisms, this review aims to shed light on the promise of probiotic and vitamin co-supplementation as a multifaceted approach to combat Alzheimer’s disease, offering insights into possible avenues for future research and clinical application.

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Systematic review of the literature on vitamin A and memory

Cited by 9 publications

References 55 publications

13-cis-Retinoic Acid Affects Brain Perfusion and Function: In Vivo Study

13-cis-Retinoic Acid Affects Brain Perfusion and Function: In Vivo Study

Cognitive interventions in mature and older adults, benefits for psychological well-being and quality of life: a systematic review study

A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer’s Disease: A Focus on Probiotic and Vitamin Co-Supplementation

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