Dysexecutive syndrome and cerebrovascular disease in non-amnestic mild cognitive impairment: a systematic review of the literature

Sudo, Felipe Kenji; Alves, Carlos Eduardo; Alves, Gilberto Sousa; Ericeira-Valente, Letice; Tiel, Chan; Moreira, Denise Madeira; Laks, Jérson; Engelhardt, Eliasz

doi:10.1590/s1980-57642012dn06030006

Cited by 18 publications

(15 citation statements)

References 51 publications

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“…For example, there is some evidence that the association between obesity and EF increases with age (Stanek et al, 2013). A potential mechanism of this age-related increase is that obesity is a risk factor for cardiovascular disease and type 2 diabetes (see the discussion of these disorders in later sections), both of which lead to neurodegenerative changes in the brain (most notably the frontal subcortical structures and frontal white matter) that are associated with declines in EF (Sudo et al, 2012;Vincent & Hall, 2015). Importantly, weight loss is associated with improvements in cognition, including EF.…”

Section: Dietmentioning

confidence: 99%

Executive Functioning and Health

Williams

Tinajero

Suchy

2017

Oxford Handbook Topics in Psychology

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This review provides an overview of research on associations between the multi-component, cognitive construct executive functioning (EF) and health. Executive functioning is defined, and issues related to measurement are detailed. The categories of potential mechanisms by which EF may be associated with health and disease are described. Key research examining EF and health behaviors, stress processes, and chronic illness is reviewed with a focus on function (behavioral performance), as well as neuroanatomical research where relevant. Across these domains, there is evidence that EF is associated with health and illness in reciprocal, feed-forward fashion across the life span. Critical limitations of the current literature are noted, along with important future directions.

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Section: Dietmentioning

confidence: 99%

Executive Functioning and Health

Williams

Tinajero

Suchy

2017

Oxford Handbook Topics in Psychology

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“…[1] Given the seminal role of memory impairment as the first basic criteria for MCI, the figures for prevalence necessitate extrapolation from non-amnesic, which averaged 16.77% (17-38%) in different studies. [14]…”

Section: Cognitive Deficits In Mild Cognitive Impairment: Memorymentioning

confidence: 99%

Mild cognitive impairment in adult: A neuropsychological review

Ouyang

Chandra

Venkatesh

2013

Ann Indian Acad Neurol

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Mild cognitive impairment (MCI) is associated with an increased risk of developing dementia. This is clinically relevant overt dementia can be prevented if treatment strategies are devised for MCI. Neuropsychological deficits in this condition are very common and are important clinically for treatment and outcomes. We aimed to review various neuropsychological deficits in MCI. Further, we have presented the current evidence for nosological status, neuroanatomical basis, and clinical outcome of this heterogeneous construct. All published papers on the topic of neuropsychological deficits in MCI on Medline and other databases were reviewed. A wide range of memory and executive function deficits are common in MCI patients. However, several studies are limited by either improper designs or inadequate sample sizes. Several neuropsychological impairments like memory function and executive functions can be diagnosed in MCI. The evidence base for the exact neuroanatomical basis of MCI is not robust yet. However, given the wide range of outcomes, controversies and debates exist regarding the nosological significance of the deficits. Hence, more studies are needed to specifically locate the impairments and further delineate the construct of MCI.

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“…The association between WMH and processing speed decline are well studied and the WMH distribution pattern is important. Extended distributions of WMH around the anterior and posterior periventricular horn region, as opposed to deep white matter areas, are associated with executive dysfunction (Lampe et al, ; Smith et al, ; Sudo et al, ; Sun et al, ). This phenomenon can be explained by WMH in different locations that are associated with white matter damage on different fibers.…”

Section: Introductionmentioning

confidence: 99%

Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi‐modality MR imaging study

Wang

Jiaerken

et al. 2019

Human Brain Mapping

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Cognitive processing speed is crucial for human cognition and declines with aging.White matter hyperintensity (WMH), a common sign of WM vascular damage in the elderly, is closely related to slower psychomotor processing speed. In this study, we investigated the association between WMH and psychomotor speed changes through a comprehensive assessment of brain structural and functional features.Multi-modal MRIs were acquired from 60 elderly adults. Psychomotor processing speeds were assessed using the Trail Making Test Part A (TMT-A). Linear regression analyses were performed to assess the associations between TMT-A and brain features, including WMH volumes in five cerebral regions, diffusivity parameters in the major WM tracts, regional gray matter volume, and brain activities across the whole brain. Hierarchical regression analysis was used to demonstrate the contribution of each index to slower psychomotor processing speed. Linear regression analysis demonstrated that WMH volume in the occipital lobe and fractional anisotropy of the forceps major, an occipital association tract, were associated with TMT-A. Besides, resting-state brain activities in the visual cortex connected to the forceps major were associated with TMT-A. Hierarchical regression showed fractional anisotropy of the forceps major and regional brain activities were significant predictors of TMT-A. The occurrence of WMH, combined with the disruption of passing-through fiber integrity and altered functional activities in areas connected by this fiber, are associated with a decline of psychomotor processing speed. While the causal relationship of this

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Dysexecutive syndrome and cerebrovascular disease in non-amnestic mild cognitive impairment: a systematic review of the literature

Cited by 18 publications

References 51 publications

Executive Functioning and Health

Executive Functioning and Health

Mild cognitive impairment in adult: A neuropsychological review

Understanding the association between psychomotor processing speed and white matter hyperintensity: A comprehensive multi‐modality MR imaging study

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