Abstract:Clozapine has become a keystone in the treatment of schizophrenia because of its
efficacy as an antipsychotic with negligible neuroleptic effects. The long-term
stability of its effects, however, is poorly understood, because most studies
have probed the usefulness of clozapine over a period of weeks to several months
at the most. Knowing whether clozapine’s benefits are sustained over the very
long-term, i.e., more than 5 years, may be critical for cost-benefit
analyses.ObjectiveTo report the results of an op… Show more
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