Cluster analysis of cognitive performance in a sample of patients with Parkinson's disease

Souza, Carolina Pinto; Oliveira, Guiomar Nascimento; Foss, Maria Paula; Tumas, Vítor

doi:10.1590/s1980-5764-2016dn1004010

Cited by 7 publications

(10 citation statements)

References 24 publications

(24 reference statements)

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“…The concept of subjective "memory" complaint is derived from amnestic MCI as this subtype has been regarded as pre-dementia status [26]. Moreover, de cits in memory, which count among the most sensitive cognitive markers for early recognition of AD [27]. However, there were notable differences between AD-MCI vs PD-MCI [28].…”

Section: Discussionmentioning

confidence: 99%

Rehabilitation training improves subjective cognitive decline in Parkinson's disease patients: A prospective analysis

Wen¹,

Yang²,

Xu³

et al. 2020

Preprint

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Background: The predictive value of subjective cognitive decline in Parkinson's disease (PD-SCD) remains controversial. However, there is growing evidence that individuals with subjective cognitive decline (SCD) are associated with Alzheimer's disease pathology and are a higher risk for cognitive decline. The aim of the present study is to characterize PD-SCD and its progression, assess the effects of rehabilitation training programs on cognitive function in PD patients.Methods: Forty-two PD patients were evaluated with a neuropsychological protocol, and classified depending on the presence (PD-SCD+, n=22) or absence of SCD (PD-SCD-,n=20). After a mean follow-up of 3.0 years (2.0-4.0 years), we repeated the cognitive assessments with the same subjects. The rehabilitation training for individuals with PD for six months after the re-assessment.Results: The clinical characteristics and overall cognitive performance of the 2 groups did not differ from baseline. During the follow-up assessment, patients with PD-SCD exhibited a more significant annual decline in Chinese-Beijing version of Montreal Cognitive Assessment-Test (BJ-MoCA) and semantic fluency than patients without PD-SCD. Stepwise logistic regression analysis showed that the MMSE Scores(P=0.000), HAMD Scores (P=0.008), male (P=0.026), and the presence of SCD (P=0.022) were risk factors for language and related functions domain. There are significant improvements detected in 2 groups after rehabilitation training in terms of BJ-MoCA. Pairwise comparisons showed that language at post-intervention in the PD-SCD+ groups were significantly higher than at pre-intervention in the PD-SCD-.Conclusion: With the progression of the disease, the cognitive performance of patients with PD-SCD+ was worse than PD-SCD-. Meanwhile, the present data indicate that semantic fluency might be a key component to evaluate the cognitive subset of PD. Rehabilitation training is a viable intervention for PD that can improve several non-motor domains, produced larger improvements in cognition.

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Section: Discussionmentioning

confidence: 99%

Rehabilitation training improves subjective cognitive decline in Parkinson's disease patients: A prospective analysis

Wen¹,

Yang²,

Xu³

et al. 2020

Preprint

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“…Domains were first compared across subdiagnoses of this cognitively normal ET sample including those diagnosed with fully normal cognition (group 1, fully normal cognition) and those labeled as having test impairment of unlikely clinical significance, test impairment of possible clinical significance, and questionable/isolated functional impairment (group 2, not-fully normal cognition) using 2-sample t-tests. K-means cluster analysis was then performed (Chiu, Douglas, & Li, 2009;Souza, Oliveira, Foss, & Tumas, 2016;Szeto et al, 2015) to identify the extent to which a set of specific cognitive profiles best described the overall sample, and bar graphs were generated, using SPSS 24. Analysis was performed at a range of cluster numbers.…”

Section: Discussionmentioning

confidence: 99%

Profiles of Normal Cognition in Essential Tremor

Cersonsky

Kellner

Chapman

et al. 2019

J Int Neuropsychol Soc

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Objectives:Patients with essential tremor exhibit heterogeneous cognitive functioning. Although the majority of patients fall under the broad classification of cognitively “normal,” essential tremor is associated with increased risk for mild cognitive impairment and dementia. It is possible that patterns of cognitive performance within the wide range of normal functioning have predictive utility for mild cognitive impairment or dementia. These cross-sectional analyses sought to determine whether cognitive patterns, or “clusters,” could be identified among individuals with essential tremor diagnosed as cognitively normal. We also determined whether such clusters, if identified, were associated with demographic or clinical characteristics of patients.Methods:Elderly subjects with essential tremor (age >55 years) underwent comprehensive neuropsychological testing. Domain means (memory, executive function, attention, visuospatial abilities, and language) from 148 individuals diagnosed as cognitively normal were partitioned using k-means cluster analysis. Individuals in each cluster were compared according to cognitive functioning (domain means and test scores), demographic factors, and clinical variables.Results:There were three clusters. Cluster 1 (n = 64) was characterized by comparatively low memory scores (p < .001), Cluster 2 (n = 39) had relatively low attention and visuospatial scores (p < .001), and Cluster 3 (n = 45) exhibited consistently high performance across all domains. Cluster 1 had lower Montreal Cognitive Assessment scores and reported more prescription medication use and lower balance confidence.Conclusions:Three patterns of cognitive functioning within the normal range were evident and tracked with certain clinical features. Future work will examine the extent to which such patterns predict conversion to mild cognitive impairment and/or dementia.

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“…All 22 of the reviewed studies were of moderate to high quality (quality range: 5-8, Supplementary Material 2). Nine studies defined subtypes based on impairment severity [13][14][15][16][17][18][19][20][21], and 11 studies revealed subtypes based on domains of impairment [22][23][24][25][26][27]. Two longitudinal studies were identified (Table 3) [28,29].…”

Section: Re Sultsmentioning

confidence: 99%

Systematic review of data‐driven cognitive subtypes in Parkinson disease

Pourzinal

Yang

Lawson

et al. 2022

Euro J of Neurology

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Background and purpose Recent application of the mild cognitive impairment concept to Parkinson disease (PD) has proven valuable in identifying patients at risk of dementia. However, it has sparked controversy regarding the existence of cognitive subtypes. The present review evaluates the current literature pertaining to data‐driven subtypes of cognition in PD. Methods Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines, systematic literature searches for peer‐reviewed articles on the topic of cognitive subtyping in PD were performed. Results Twenty‐two relevant articles were identified in the systematic search. Subtype structures showed either a spectrum of severity or specific domains of impairment. Domain‐specific subtypes included amnestic/nonamnestic, memory/executive, and frontal/posterior dichotomies, as well as more complex structures with less definitive groupings. Preliminary longitudinal evidence showed some differences in cognitive progression among subtypes. Neuroimaging evidence provided insight into distinct patterns of brain alterations among subtypes. Conclusions Recurring phenotypes in the literature suggest strong clinical relevance of certain cognitive subtypes in PD. Although the current literature is limited, it raises critical questions about the utility of data‐driven methods in cognitive research. The results encourage further integration of neuroimaging research to define the latent neural mechanisms behind divergent subtypes. Although there is no consensus, there appears to be growing consistency and inherent value in identifying cognitive subtypes in PD.

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Cluster analysis of cognitive performance in a sample of patients with Parkinson's disease

Cited by 7 publications

References 24 publications

Rehabilitation training improves subjective cognitive decline in Parkinson's disease patients: A prospective analysis

Rehabilitation training improves subjective cognitive decline in Parkinson's disease patients: A prospective analysis

Profiles of Normal Cognition in Essential Tremor

Systematic review of data‐driven cognitive subtypes in Parkinson disease

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