Rosai-Dorfman em seios paranasais como diagnóstico diferencial de polipose nasosinusal na infância

Avelino, Melissa Ameloti Gomes; Elias, Thaís Gomes Abrahão; Rezende, Renata Martins Dayrel; Lima, Ana Paula Lindoso; Gonçalves, Alexandra Vilela

doi:10.1590/s1808-86942012000300024

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Rosai-Dorfmann disease is a benign histiocytic disorder, derived from a macrophage lineage, and may clinically present in a similar fashion to xanthogranuloma but is typically associated with massive lymphadenopathy and "B" symptoms. It also expresses positivity to S-100, CD68, and CD163 but is negative for CD1a [3,4]. Rhinoscleroma is a chronic granulomatous condition that may also present as a maxillary sinus mass but is associated with Klebsiella rhinoscleromatis infection [5,6].…”

Section: Discussionmentioning

confidence: 99%

The Rare Case of an Adult-Onset Xanthogranuloma of the Paranasal Sinuses: A Histological Dilemma

Bastianpillai

Haloob

Panchappa

et al. 2020

Case Reports in Pathology

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Xanthogranuloma is a rare benign tumour, part of the non-Langerhans cell histiocytosis group, uncommon in adults and even less common in the paranasal sinuses. Despite its benign nature, it mimics neoplasm due to its local effects which can have serious functional consequences depending on the anatomical location. We present the rare case of a young lady who presented insidiously with a maxillary sinus xanthogranuloma and was treated with endoscopic resection. Tissue diagnosis is of paramount importance to guide correct further investigations and management, and we discuss the potential challenge in identifying such a rarely seen pathology.

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Section: Discussionmentioning

confidence: 99%

The Rare Case of an Adult-Onset Xanthogranuloma of the Paranasal Sinuses: A Histological Dilemma

Bastianpillai

Haloob

Panchappa

et al. 2020

Case Reports in Pathology

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Manifestations of Pediatric Extranodal Rosai Dorfman Disease in the head and neck

Alwani

Elghouche

Schueth

et al. 2020

International Journal of Pediatric Otorhinolaryngology

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Cytomorphological and Morphometric Analysis of 22 Cases of Rosai-Dorfman Disease: A Large Series from a Tertiary Care Centre

Mallick

Ghosh²,

Iyer³

et al. 2013

Acta Cytologica

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Background: Rosai-Dorfman disease (RDD) is a rare benign idiopathic histiocytic proliferation. Most commonly reported cases are lymph nodal. Only 30-40% of cases occur in extranodal sites. Although the morphological features of RDD are well documented, there is limited information about the morphometric variations in the histiocytes of this entity. Method: Twenty-two cases of RDD diagnosed on fine-needle aspiration cytology (FNAC) were retrieved from the archives. Both Papanicolaou- and May-Grünwald-Giemsa-stained slides were available for evaluation in all cases. Nuclear area, diameter and histiocyte size were measured taking reactive histiocytes as controls. Results: Among the 22 patients (male/female ratio 3:2; age range 5-55 years, mean 26 years), 3 cases were extranodal and 19 cases were nodal. The nodal sites included cervical, axillary, inguinal and submandibular lymph nodes. The extranodal sites were the retroperitoneum, mediastinum and skin. The most common clinical presentation was enlarged lymph nodes. Cytological features included numerous large benign histiocytes with emperipolesis. All the morphometric parameters were significantly (p < 0.01) higher in RDD histiocytes than in histiocytes in the reactive lymph node. Conclusions: In view of the rarity of the disease and the variable clinical presentation in RDD, accurate diagnosis is necessary. This is the first study to document the morphometric parameters of RDD histiocytes and their comparison with histiocytes in the reactive lymph node.

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Rosai-Dorfman em seios paranasais como diagnóstico diferencial de polipose nasosinusal na infância

Cited by 3 publications

References 6 publications

The Rare Case of an Adult-Onset Xanthogranuloma of the Paranasal Sinuses: A Histological Dilemma

The Rare Case of an Adult-Onset Xanthogranuloma of the Paranasal Sinuses: A Histological Dilemma

Manifestations of Pediatric Extranodal Rosai Dorfman Disease in the head and neck

Cytomorphological and Morphometric Analysis of 22 Cases of Rosai-Dorfman Disease: A Large Series from a Tertiary Care Centre

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