Mandibular myofibrosarcoma of childhood: surgical resection &amp; reconstruction with fibula flap

Shnayder, Yelizaveta; Key, Vincent; Girod, Douglas A.; Tsue, Terrance T.

doi:10.1590/s1808-86942011000300024

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Malignant tumours showing myofibroblastic differentiations are rare, and their biological behaviour is far from being elucidated. To date, only seven cases of MS of the jaws in children have been reported in the English literature, including the current case (Table ).…”

Section: Discussionmentioning

confidence: 84%

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High‐grade myofibroblastic sarcoma of the mandible: case report in a child and literature review

et al. 2014

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Myofibroblastic sarcoma (MS) is a rare neoplasm with a predilection for the head–neck region. Most MSs are low‐grade tumours, but a rarer, less differentiated, high‐grade variant has been described. To date, only six cases of MS have been reported in children, all low‐grade tumours. We report a case of aggressive MS, presented as an ulcerated mass in the anterior region of the mandible of an 11‐year‐old girl. Radiographs showed extensive bone destruction and ‘floating‐in‐air’ teeth displacement. Histopathological analysis revealed proliferation of pleomorphic spindle‐shaped and round cells arranged in a storiform and fascicular pattern. Immunohistochemically, tumour cells showed intense positivity for α‐smooth muscle actin and vimentin but focal for desmin, CD99 and HHF‐35. Laminin, S‐100 protein, CD68, pan‐cytokeratin and epithelial membrane antigen were negative. These findings were interpreted as high‐grade MS. Chemotherapy and segmental mandibulectomy were used to achieve local control, but the patient died 6 months later as a result of multiple metastases.

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Section: Discussionmentioning

confidence: 84%

“…To date, only seven cases of MS of the jaws in children have been reported in the English literature, including the current case (Table ). When involving the jaws, MS presents as a painless destructive osteolytic lesion, with no periosteal reaction.…”

Section: Discussionmentioning

confidence: 99%

High‐grade myofibroblastic sarcoma of the mandible: case report in a child and literature review

et al. 2014

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“…88,89 Their clinical importance lies in the resemblance, particularly of low-grade examples, to reactive or pseudosarcomatous conditions such as nodular fasciitis. They usually occur in adults, but can more rarely affect children.…”

Section: Low-grade Myofibrosarcomamentioning

confidence: 99%

Pediatric Fibroblastic and Myofibroblastic Lesions

Thway¹,

Fisher²,

Sebire³

2012

Advances in Anatomic Pathology

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Fibrous lesions of infancy and childhood are a heterogeneous group of entities composed predominantly of fibroblasts and myofibroblasts, ranging from reactive lesions to neoplasms with a range of malignant potential. Although rare, their correct recognition by histopathology is important clinically as they exhibit a wide range of behaviors and may be associated with distinct underlying syndromes. Contributions from molecular diagnostics have enabled more accurate diagnosis, and have changed our concepts of some tumor types. In this review, we discuss the clinicopathologic spectrum of fibroblastic and myofibroblastic lesions of childhood and adolescence.

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