Lesões sequelares na laringe em pacientes com paracoccidiodomicose

Abstract

Sequela lesions of the laryngeal PCM are extensive and cause functional limitations in most cases.

Impact of laryngeal sequelae on voice- and swallowing-related outcomes in paracoccidioidomycosis

“…PCM is the most prevalent chronic infection of the upper airdigestive tract in Latin America, whose importance is related to its severity, sequelae in spite of appropriate therapy, and repercussion on the quality of life [ 10 , 11 ]. Consistent with previous studies [ 12 , 13 , 14 , 15 ], most of our patients were men, adults, cigarette smokers and alcoholics who previously resided or currently reside in rural areas.…”

Voice disorders in residual paracoccidioidomycosis in upper airways and digestive tract

“…Gender and age of the patients within our group were not different from other studies, showing prevalence of males, with average age around 40 years. 2,4,6,8,11,17,22 Studies indicate that the frequency of chronic cases is very low among women, and that is related to the inhibitory action of estrogen over the fungus transformation from mycelium, the infective form, to yeast, parasitic phase. 11 As in other diseases, PCM patients present alcoholism and smoking as associated factors.…”

“…2,4,6,8,11,17,22 Studies indicate that the frequency of chronic cases is very low among women, and that is related to the inhibitory action of estrogen over the fungus transformation from mycelium, the infective form, to yeast, parasitic phase. 11 As in other diseases, PCM patients present alcoholism and smoking as associated factors. 14 Smoking and alcoholism are frequent in PCM patients, being considered risk factors for the disease, once they interfere in the agent-host relationship.…”

“…The scar lesions on the larynx caused by Paracoccidioides brasiliensis are described as extensive and causing functional restrictions in most cases. 11 The vocal folds' mucous membranes, when affected by the infection, become more rigid, which alters its function and may create an asymmetry in the vibration of the vocal folds. 18 In the GRBASI scale analysis, the most observed voice disorder was roughness in a moderate degree, consistent with the most affected anatomic site, the vocal folds.…”

Laryngeal paracoccidioidomycosis presenting as solitary true vocal fold disease

“…Interestingly, fatigue, weight loss, and fever seem not to be prominent manifestations [8] . It usually presents as ulcerated lesions with a mulberry-like appearance or as vegetations, and many patients have multiple laryngeal lesions, with involvement of the true and false vocal folds, the epiglottis, and the arytenoid and interarytenoid areas [8] , [12] . In a case series of 17 consecutive cases with laryngeal PCM diagnosed between 1978 and 1999 in Rio de Janeiro, lesions were often present at multiple mucosal sites (laryngeal and non-laryngeal), and lung involvement was common [13] .…”