Perfil de citocinas da polipose nasossinusal na Fibrose Cística comparado com indivíduos sem doenças nasossinusais

Nunes, Flávio Barbosa; Castro, Mirian Cabral Moreira de; Silva, Tacimara Moreira da; Araújo, Ricardo Nascimento; Becker, Helena Maria Gonçalves; Crosara, Paulo Fernando Tormin Borges; Guimarães, Roberto Eustáquio Santos

doi:10.1590/s1808-86942010000100005

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…In this study, no differences of salivary IL-8 and IL-6 were observed between CF patients with NP and without NTH/NP. Accordingly, a cross-sectional study reported similar levels of IL-8 and IL-6 mRNA in CF patients with and without NP [18]. We observed that salivary TNF-α was significantly reduced in patients with NP, which is the most advanced phase of the sinonasal disease.…”

Section: Discussionsupporting

confidence: 53%

“…Furthermore, an increase of IL-8 and IL-5 was observed in the nasal secretions of patients with CF compared to healthy subjects, but no significant differences were found between patients with and without NP [17]. In addition, Nunes et al [18] reported similar mRNA levels of IL-8 and IL-6 in CF patients with and without NP. On the other hand, the cytokine profile in airway fluids from CF patients with NTH and the differences of cytokine profile between CF patients with NP and NTH have not been well investigated.…”

Section: Introductionmentioning

confidence: 94%

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Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis

et al. 2020

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About 50% of patients with cystic fibrosis (CF) have sinonasal complications, which include inferior turbinate hypertrophy (NTH) and/or nasal polyposis (NP), and different degrees of lung disease, which represents the main cause of mortality. Monitoring of sinonasal disease requires complex instrumental procedures, while monitoring of lung inflammation requires invasive collection of bronchoalveolar lavage fluid. The aim of this study was to investigate the associations between salivary cytokines levels and CF-related airway diseases. Salivary biochemical parameters and cytokines, i.e., interleukin-6 (IL-6), IL-8, and tumor necrosis factor alpha (TNF-α), were analyzed in resting saliva from healthy subjects and patients with CF. Patients with CF showed significantly higher levels of salivary chloride, IL-6, IL-8, and TNF-α and lower calcium levels than healthy subjects. Among patients with CF, IL-6 and IL-8 were significantly higher in patients with NTH, while TNF-α was significantly lower in patients with NP. A decreasing trend of TNF-α in patients with severe lung disease was also observed. On the other hand, we did not find significant correlation between cytokine levels and Pseudomonas aeruginosa or Stenotrophomonas maltophilia colonization. These preliminary results suggest that salivary IL-6 and IL-8 levels increase during the acute phase of sinonasal disease (i.e., NTH), while the end stages of pulmonary disease and sinonasal disease (i.e., NP) show decreased TNF-α levels.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 94%

Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis

et al. 2020

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“…To better understand the pathogenic mechanisms of nasal polyps in CF, several studies have tried to characterize the inflammatory microenvironment, cytokines, adhesion molecules, and ionic transport. A Brazilian study conducted by Nunes and coworkers [ 38 ] analyzed the expression of messenger ribonucleic acid (mRNA) for cytokines IL4, IL5, IL6, IL8, GM-CSF, and INF-gamma in patients with CF, who had nasal polyposis, and in a control group, using reverse transcription-polymerase chain reaction (RT-PCR). The resulting expression of mRNA for IL5, IL6, IL8, and GM-CSF was similar in the group with CF polyposis and in the control group.…”

Section: Profile Of Cytokines In Sinonasal Polyposis In Cfmentioning

confidence: 99%

“…These bacteria stimulated production of IL4 by Th2 cells. The results would reflect intense inflammation with an increase in the eosinophilic cationic protein, total IgE, intermediated by the increase of IL4 and the low INF-gama [ 38 ].…”

Section: Profile Of Cytokines In Sinonasal Polyposis In Cfmentioning

confidence: 99%

Cystic Fibrosis: Brazilian ENT Experience

Sih

Godinho

Franco

et al. 2012

International Journal of Otolaryngology

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Most published studies about Cystic Fibrosis (CF) are European or North American. There are still few publications about the characteristics of fibrocystic populations in developing countries. The incidence of cystic fibrosis (CF) in Brazil varies among different regions (1 : 10,000 in Minas Gerais, 1 : 9,500 in Paraná, 1 : 8,700 in Santa Catarina, and 1 : 1600 in Rio Grande do Sul). The prevalence of the DF508 mutation also varies according to population: 33% in Sao Paulo, 49% in Rio Grande do Sul, 27% in Santa Catarina, and 52% in Minas Gerais. Cough and nasal obstruction are the most common symptoms. The variation in nasal polyposis prevalence may be explained by population genotypic characteristics in a country that spans a continent. Findings on nasal endoscopy and computed tomography (CT) have better correlation than do this information compared with surgical and clinical history. Microbiologic studies suggest a high level of early contamination of the airways. Sensorineural hearing loss (SNHL) occurs in these patients as a result of ototoxic antibiotics. The data compiled in this paper is useful, but also lead to the general agreement that more research would be welcome due to the unique characteristics of this country.

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