Parotid neoplasms: analysis of 600 patients attended at a single institution

Abstract

Sal ivary gland tumors are rare, generally benign and affect mainly the parotid gland. Aim. The purpose of this study was to retrospectively analyze all cases of parotid tumors treated at our institution from 1953 to 2003. Methods. All patients with primary parotid tumors were selected; clinical and histopathological data were analyzed and described. Results. 600 cases of parotid tumors were selected; 369 were benign and 231 were malignant. Pleomorphic adenoma was the most frequent benign tumor. The most common malignant tumor was the mucoepidermoid carcinoma. Therapy in most cases consisted of parotidectomy. Adjuvant therapy-mainly radiotherapy-was used in some cases with malignant tumors. The incidences of local, regional and distant recurrences of malignant tumors were 10%, 8% and 9%. Conclusion. Patients with parotid tumors treated at our institution were mainly adults, with marginally more female patients. Benign tumors were mostly the pleomorphic adenoma, which were more frequent than malignancies. Most of the patients were treated by partial or total parotidectomy. Adjuvant therapy, mainly radiotherapy, was used in selected malignant cases.

Descriptive epidemiology of salivary gland neoplasms in Nigeria: An AOPRC multicenter tertiary hospital study

“…Similar age trends were observed for benign and malignant SGN with peak incidences at 44 and 59 years, respectively. The higher incidence and age in the malignant group is consistent with what has been reported in most studies (Araya et al, ; Masanja et al, ; Satko et al, ; Takahama Junior et al, ; Tartaglione et al, ).…”

“…We observed mean ages of diagnosis for benign tumors to be 37.1 (±15.4) years and malignant tumors to be 48.9 (±17.3) years. The mean age of diagnosis for malignant tumors in our study is similar to that reported for both benign and malignant tumors in Tanzania (Masanja, Kalyanyama, & Simon, ) and Brazil (Takahama Junior, Almeida, & Kowalski, ). Our observed mean ages of diagnosis were, however, lower than ages reported in a study by SatkoStanko & Longauerova, in Slovakia; where the mean ages reported for benign and malignant tumor were 46 and 53 years, respectively (Satko et al, ).…”

Clinicopathologic Investigation of Parotid Gland Masses: Retrospective Analysis of 121 Cases

“…Parotis kökenli benign tükrük bezi tümörleri içinde en sık karşılaşılan pleomorfik adenomdur ve karşıla-şılma sıklığı en yüksek beşinci dekattadır 8. literatür gözden geçirildiğinde pleomorfik adenomun benign tümörlerin %51-53'ünü oluşturduğunu bildiren yayınlar mevcuttur 1,3,8 . Biz de çalışmamızda, benign tü-mörler içerisinde pleomorfik adenom görülme oranı %52,5 olarak literatüre uyumlu şekilde bulunmuştur.…”

“…Çalışmamızda, Whartin tümörü tüm parotis kitleleri içinde 37 hastada tespit edilmiş olup, ameliyat edilen tüm hastaların %30,5'lik bir kısmını oluşturmaktadırlar. Bu oranın literatürde-ki sonuçlarla karşılaştırıldığında daha yüksek olduğu görülmektedir 1,3 . Whartin tümörleri benign tümörler olarak kabul edilmelerine rağmen, hem %10 civarında bilateral görülebilmeleri hem de boyuna lenf nodlarına metastaz yapabilme ihtimalleri de olması nedeniyle bu hastalar yakın takibe alınmalıdır…”

“…Parotis bezinin en sık görülen malign tümörü mukoepidermoid karsinomdur 1,3 . Literatürde mukoepidermoid karsinom görülme sıklığı %3-18 olarak bildirilmiştir 1,7 .…”