ABSTRACT. We report a case of calcifying epithelial odontogenic tumour (CEOT), also known as a Pindborg tumour, with local aggressive behaviour. CT imaging showed a large expansile bone-forming lesion in the mandible, which showed the exact extent and nature of the lesion. We briefly discuss the imaging features of CEOT and the relevant literature. A calcifying epithelial odontogenic tumour (CEOT) is a rare benign odontogenic neoplasm described in 1955 by Pindborg and is now known as a Pindborg tumour. This lesion represents approximately 0.4-3.0% of all odontogenic tumours [1]. To the best of our knowledge, the imaging characteristics of CEOT have been reported in only two cases in the literature [2,3]. We present the CT findings of a CEOT, discuss the contribution of CT to its diagnosis and review the relevant literature.
Case reportA 33-year-old female presented with a progressive, painless enlargement of left lower jaw, which she had had for 3 years. A clinical examination revealed a welldefined huge extra-oral bony, hard non-tender swelling involving the left body and angle of the mandible. Intraorally, a well-defined hard, non-tender swelling was seen in buccal vestibule extending from the mandibular left first premolar to the retromolar region with bicortical expansion present. The left lower first molar was missing.An orthopantomograph revealed a large mixed radioopaque-radiolucent lesion in the left body and angle of the mandible with extension into the ramus and with an intact lower border of the mandible. An unerupted first molar was pushed towards the inferior border of mandible. The calcifications were concentrated around the unerupted first molar (Figure 1). CT images were obtained in axial, coronal, sagittal and panoramic views with a three-dimensional (3D) reconstruction. The coronal section revealed a large expansile multilocular and trabeculated lesion involving the left half of the body of the mandible including the level of the ramus and the alveolar margin and was seen extending up to symphysis (Figure 2). The lesion had thinned out and destroyed the mandibular cortices (lingual to buccal) and infiltrated the oral cavity as well as the soft tissue. An impacted unerupted first molar was seen within the lesion (Figure 3). Multiple ossicles and ossific densities with 500-1800 HU were seen throughout the lesion; however, they were more concentrated at the crown of the unerupted first molar. Multidimensional CT reconstructions using hard and soft tissue algorithms demonstrated the size and extent of the lesion, which was essential for surgical planning (Figures 4, 5).Fine needle aspiration cytology was performed and the cytology smear demonstrated features suggestive of a CEOT. A surgical excision was carried out under general anaesthesia and histological analysis confirmed a CEOT.
DiscussionA CEOT is a benign neoplasm of unknown cause related to the odontogenic apparatus. It occurs frequently between 30 and 50 years of age with no gender predilection [4]. The tumours are divided according to the...