LANGERHANS CELL HISTIOCYTOSIS OF THE SCAPULA - DIAGNOSIS &amp; TREATMENT OPTIONS

Pandey, Rahul; Bhayana, Himanshu; Rajneesh, Rajesh Kumar; Dhammi, Ish Kumar; Ul-Haq, Rehan; Jain, Anil K.

doi:10.1590/s1808-185120171603173214

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Scapular and humeral involvements were rare in this study, and our results showed only two case reports of scapular involvement, and one case of humeral involvement. Khung et al [ 9 ] believed that “scapular lesions are not uncommon in children”, but Pandey et al [ 47 ] reported the scapula as a rare location of LCH; based on our findings, the scapula seems to be a rare presentation of LCH. Kim et al [ 69 ] reported the humerus as a frequent site in children, but our findings did not support their results; further studies are warranted in this area.…”

Section: Discussionsupporting

confidence: 56%

Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature

Reisi

Raeissi

Khalilabad

et al. 2021

Orphanet J Rare Dis

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Background Langerhans cell histiocytosis (LCH) is a rare disease that originates from the uncontrolled proliferation and accumulation of bone marrow-derived immature myeloid dendritic cells. Dendritic cells are a type of histiocyte that play an important role in the human immune system and are found in the bone, skin, stomach, eyes, intestines, and lungs. Objective This systematic review aimed to collect and report published case reports of rare bone disease caused by LCH to avoid misdiagnoses or delays in diagnosis. Methods We systematically searched Scopus, PubMed, Embase, and Web of Sciences from August 1, 2000 to December 31, 2019. Studies reporting cases of LCH with rare bone involvement were included. Results We identified 60 articles including 64 cases. Of the identified cases, 31 (48.4%) involved children, and 33 (51.6%) involved adults. Additionally, 46.9% (30 individuals) were from Asian countries. The mean age of the children was 7.6 ± 4.3 years and that of the adults was 36 ± 12 years. The findings indicated that unifocal bone involvements were the most prevalent form of the disease (68.7%), and, overall, the skull and chest wall were the most commonly affected bones in both adults and children. The spine and long bones were the second most commonly affected bones in children, and the spine and jaw were the second most commonly affected bones in adults. Pain and swelling were the most frequent presenting signs among the investigated cases, and loss of consciousness, myelopathy, nerve palsy, visual loss, torticollis and clicking sounds were rare signs. Osteolytic lesions were the most frequent radiologic feature (62.5%), and intracranial hemorrhage, fluid–fluid level, dura and intracranial extension and pathologic fractures were rare radiological features. Total excision, curettage and observation in the unifocal group of patients and systemic chemotherapy in the other groups (i.e., multifocal and multisystem) were the most frequent management approaches. The recovery rates of the unifocal and multifocal groups were 77.3% and 81.8%, respectively, while that of the multisystem group was 55.5%. The rates of recurrence and mortality in the multisystem group were 11% and were higher than those in the other groups. Conclusions LCH is a rare disease that can affect any organ in the human body. However, bone is the most commonly involved organ, and rare bone involvements may be the first or only symptom of the disease due to the rarity of such lesions; a lack of familiarity with them may result in misdiagnosis or delayed diagnosis.

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Section: Discussionsupporting

confidence: 56%

Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature

Reisi

Raeissi

Khalilabad

et al. 2021

Orphanet J Rare Dis

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“…Pandey, et al [12] reported the unifocal LCH of the scapula in a 10-year-old boy, with pain and restriction of the right shoulder's movement since one year previously. The biopsy reports (numerous histiocytes and pleomorphic eosinophils) and immunochemical fi ndings (positive CD68 and S100) confi rmed the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Langerhans Cell Histiocytosis of the Right Scapula

Moradi¹,

Babaniamansour²,

Majidi³

et al. 2021

J Biomed Res Environ Sci

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Langerhans Cell Histiocytosis (LCH) is a rare granulomatous disease with an unknown origin. LCH occurs at any age and affects any organ. It is presented as self-limited to aggressive forms. Late diagnosis of LCH, after the evidence is revealed at the radiological imaging or microscopic investigations, aggravates the possible complications. This study reported a rare case of LCH with a bone lytic lesion at the right scapula with a good prognosis.

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Adult Scapular Langerhans Cell Histiocytosis Mistaken for Acute Osteomyelitis

Ahn

Kim

2023

J Korean Orthop Assoc

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LANGERHANS CELL HISTIOCYTOSIS OF THE SCAPULA - DIAGNOSIS & TREATMENT OPTIONS

Cited by 3 publications

References 14 publications

Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature

Unusual sites of bone involvement in Langerhans cell histiocytosis: a systematic review of the literature

Langerhans Cell Histiocytosis of the Right Scapula

Adult Scapular Langerhans Cell Histiocytosis Mistaken for Acute Osteomyelitis

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