Sudden unexpected death in epilepsy: an important concern

Scorza, Fúlvio A.; Cysneiros, Roberta Monterazzo; Albuquerque, Marly de; Scattolini, Marcello; Arida, Ricardo Mário

doi:10.1590/s1807-59322011001300008

Cited by 25 publications

(16 citation statements)

References 48 publications

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“…Still, when it comes to epilepsy associated with LQTS 1, the molecular mechanisms remain unclear. Sudden unexplained death in epilepsy is a recognized event among patients with epilepsy (17% prevalence) [2] . In addition, KCNQ1 expression (a component of potassium current channels) in forebrain neuronal networks and brainstem nuclei (regions in which anomalies of neurons repolarization after an action potential can produce seizures and dysrhythmias) was demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Resuscitation of sudden cardiac death caused by acute epileptic seizures: A case report

Geavlete

Ionita

Mandeş

et al. 2016

Journal of Acute Disease

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Long QT dysrhythmias Epilepsy and congenital long QT syndrome Management of congenital long QT syndrome A B S T R A C T Symptomatic long QT syndrome in pediatric patients is a life-threatening condition. Sometimes, this pathology can be misdiagnosed and erroneously managed as generalized epilepsy due to similar clinical manifestations. The presented case discusses a 13-year-old female patient with generalized epilepsy since the age of 4, admitted for two episodes of resuscitated cardiac arrest due to torsades de pointes and ventricular fibrillation. The final diagnosis of congenital long QT was established and due to the patient's high-risk profile for future cardiac events, implantable cardiac defibrillator was subsequently indicated. Early recognition of congenital long QT and timing of cardiac therapy were crucial and potentially lower the incidence of fatal dysrhythmias commonly associated this condition. In high-risk patients, both medical and interventional therapy can be life-saving.

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Section: Discussionmentioning

confidence: 99%

Resuscitation of sudden cardiac death caused by acute epileptic seizures: A case report

Geavlete

Ionita

Mandeş

et al. 2016

Journal of Acute Disease

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“…Definite SUDEP is defined as the sudden, unexpected, witnessed or unwitnessed, nontraumatic, and nondrowning death of patients with epilepsy with or without evidence of a seizure, excluding documented status epilepticus, and in whom postmortem examination does not reveal a structural or toxicological cause for death [Tomson et al, ]. Cases fulfilling this SUDEP definition are classified as “definite SUDEP;” meanwhile, sudden deaths occurring in benign circumstances with no known competing cause for death but without autopsy are classified as “probable SUDEP” [Tomson et al, ; Scorza et al, ]. According to the definition, the case reported in this paper should be classified as probable SUDEP.…”

Section: Discussionmentioning

confidence: 99%

Interstitial deletion 5q14.3q21.3 associated with lethal epilepsy

Yang

Yao

Guo

et al. 2015

American J of Med Genetics Pt A

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The 5q14.3 deletion syndrome is a heterogeneous disorder with remarkable phenotypic diversity ranging from severe to mild manifestation. In this paper, we report on a patient with 5q14.3 q21.3 deletion who exhibited the severe phenotype and died at 5.5 months. This patient can be classified as having sudden unexplained death in epilepsy (SUDEP) [Tomson et al., 2008]. The deleted region (21.02 Mb, Chr.5: 88, 047, 621-109,072,596 × 1 dn), which included MEF2C and EFNA5, was a 16.5 Mb sequence that overlapped with previously reported deletions in a patient with the mild phenotype. This study further demonstrated the complexity of clinical cytogenetic correlation of the 5q14.3 deletion.

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“…Epileptic seizures can induce changes in the balance between sympathetic and parasympathetic influence on the heart including an acute autonomic dysfunction suspected to play a role in sudden unexpected death in epilepsy (SUDEP) [2][3][4][5][6][7][8][9][10][11][12], and it has been suggested that a high sympathetic tone ictally and interictally is the main cause of lower HRV and SUDEP [2,3].…”

Section: Introductionmentioning

confidence: 99%