Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers

Barros, Marina Carvalho de Moraes; Mitsuhiro, Sandro; Chalem, Elisa; Laranjeira, Ronaldo; Guinsburg, Ruth

doi:10.1590/s1807-59322011000900016

Cited by 12 publications

(10 citation statements)

References 28 publications

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“…Although a growing body of literature exists on MCSDP-associated alterations in placental methylation, there is much work yet to be done to elucidate the specific signaling pathways and mechanisms involved in mediating the relationship between MCSDP and disease risk in later life. Ongoing cohort studies may help to further discern the risks posed by MCSDP to infant and child health outcomes, including risks for respiratory disorders, 110 , 111 , 113 , 114 , 116 adverse neurodevelopmental outcomes, 15 , 16 , 60 , 61 , 64 , 85 , 145 and obesity, 17 – 19 all of which have been linked to MCSDP.…”

Section: Discussionmentioning

confidence: 99%

“… 58 By negatively impacting the function of these placental cell types, MCSDP can increase the risk of placenta previa, placental abruption, 59 and other reproductive problems. MCSDP is associated with detriments to infant neurobehavior 15 , 16 , 60 – 64 and the development of autoimmune diseases. 65 – 67 Both active 68 – 73 and passive 71 , 73 – 75 MCSDP are linked to small-for-gestational-age infants.…”

Section: Cigarette Smoking In Pregnancy: Known Risks To Fetal Health mentioning

confidence: 99%

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Altered placental DNA methylation patterns associated with maternal smoking: current perspectives

Maccani¹,

Maccani²

2015

AGG

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The developmental origins of health and disease hypothesis states that adverse early life exposures can have lasting, detrimental effects on lifelong health. Exposure to maternal cigarette smoking during pregnancy is associated with morbidity and mortality in offspring, including increased risks for miscarriage, stillbirth, low birth weight, preterm birth, asthma, obesity, altered neurobehavior, and other conditions. Maternal cigarette smoking during pregnancy interferes with placental growth and functioning, and it has been proposed that this may occur through the disruption of normal and necessary placental epigenetic patterns. Epigenome-wide association studies have identified a number of differentially methylated placental genes that are associated with maternal smoking during pregnancy, including RUNX3, PURA, GTF2H2, GCA, GPR135, and HKR1. The placental methylation status of RUNX3 and NR3C1 has also been linked to adverse infant outcomes, including preterm birth and low birth weight, respectively. Candidate gene analyses have also found maternal smoking-associated placental methylation differences in the NR3C1, CYP1A1, HTR2A, and HSD11B2 genes, as well as in the repetitive elements LINE-1 and AluYb8. The differential methylation patterns of several genes have been confirmed to also exhibit altered gene expression patterns, including CYP1A1, CYP19A1, NR3C1, and HTR2A. Placental methylation patterns associated with maternal smoking during pregnancy may be largely gene-specific and tissue-specific and, to a lesser degree, involve global changes. It is important for future research to investigate the mechanistic roles that these differentially methylated genes may play in mediating the association between maternal smoking during pregnancy and disease in later life, as well as to elucidate the potential influence of emerging tobacco product use during pregnancy, including the use of electronic cigarettes, on placental epigenetics.

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Section: Discussionmentioning

confidence: 99%

Section: Cigarette Smoking In Pregnancy: Known Risks To Fetal Health mentioning

confidence: 99%

Altered placental DNA methylation patterns associated with maternal smoking: current perspectives

Maccani¹,

Maccani²

2015

AGG

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“…4 , in a cross-sectional observational study involving 388 infants born to teenage mothers, observed that newborns of mothers who smoked (6.5%) showed, within the first 24-48 hours of life, significant difference in the number of waking periods and excitability, when compared to those born to nonsmoker mothers.…”

Section: Introductionmentioning

confidence: 99%

Tabagismo: o que tem sido abordado em periódicos brasileiros

Prado¹,

Lombardi²,

Miethke-Morais³

et al. 2012

Arq. Bras. Cardiol.

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“…Por ejemplo, Fried y Smith (2001) encontraron variaciones en el desempeño en tareas con demandas de control cognitivo de adolescentes de 13 a 16 años de edad, que habían sido expuestos al consumo de ambas sustancias durante la etapa prenatal. Recientemente, Barros, Mitsuhiro, Chalem, Laranjeira, & Guinsburg (2011) encontraron que la exposición a tabaco durante el embarazo se asoció con niveles más altos de excitabilidad y de dificultades de regulación emocional en la etapa perinatal. Si bien aún es necesario incluir en este tipo de estudios análisis que permitan identificar los mecanismos de mediación a través de los cuales estos agentes generan su impacto, los resultados sugieren que la exposición prenatal a tabaco y marihuana se asocia con el desarrollo de dificultades en el procesamiento autorregulatorio durante las primeras dos décadas de vida.…”

Section: Exposición a Tóxicos Ambientales Y A Drogas Legales E Ilegalesunclassified

6000 días más: evidencia neurocientífica acerca del impacto de la pobreza infantil

Lipina

Segretin

2015

Psicología Educativa

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información del artículoHistoria del artículo: Recibido el 19 de junio de 2015 Aceptado el 8 de agosto de 2015 On-line el 9 de octubre de 2015Palabras clave: Pobreza infantil Desarrollo cerebral Períodos críticos r e s u m e n El estudio neurocientífico de la pobreza infantil realizado por diferentes grupos de investigación durante las últimas dos décadas ha permitido acumular evidencia que indica que el impacto de las carencias materiales y simbólicas por pobreza, desde la concepción, puede limitar las oportunidades de desarrollo e inclusión social de las personas durante todo su ciclo vital. No obstante, la potencialidad de cambio inherente a la plasticidad neural, las diferencias individuales y las posibilidades de modificación del desarrollo autorregulatorio por intervención ambiental (i.e., familiar, escolar y comunitaria) también indican que los impactos no son iguales en todos los casos, que no hay un período crítico para el desarrollo cognitivo y las competencias de aprendizaje que se limite a los primeros 1000 días, que la irreversibilidad del impacto de la pobreza no es un fenómeno que afecte a todos los niños que la padecen y que la pobreza no implica necesariamente déficit del desarrollo. © 2015 Colegio Oficial de Psicólogos de Madrid. Publicado por Elsevier España, S.L.U. Este es un artículo Open Access bajo la licencia CC BY-NC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/). 6000 more days: Neuroscientific evidence about the impact of childhood poverty Keywords: Childhood poverty Brain development Critical periods a b s t r a c tNeuroscientific study on child poverty carried out by several research groups over the last two decades has allowed us to gather evidence showing that the impact of material and symbolic needs from poverty, may from the onset limit opportunities of development and social inclusion of people throughout their life cycle. Nevertheless, the potential shift inherent to neural plasticity, individual differences, and the potential change of self-regulatory development by means of environment intervention (i.e., family, school, and community) also show that impacts are not the same for every child, that there is no critical period for cognitive development and learning competencies that is limited to the first 1,000 days, that irreversibility of poverty impact is not a fact that affects every child exposed to it, and that poverty does not necessary means developmental deficit. © 2015 Colegio Oficial de Psicólogos de Madrid. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).El estudio neurocientífico contemporáneo de la pobreza propone estudiar cómo diferentes factores individuales y ambientales asociados a ingresos bajos o condiciones de vida en las que no se logran satisfacer necesidades básicas (i.e., alimentación, vivienda, educación y salud) influencian al desarrollo neural. Tres aspectos * Autor para correspondencia.Correo electrónico: lipina@gmail.com (S.J. Lipina).

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Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers

Cited by 12 publications

References 28 publications

Altered placental DNA methylation patterns associated with maternal smoking: current perspectives

Altered placental DNA methylation patterns associated with maternal smoking: current perspectives

Tabagismo: o que tem sido abordado em periódicos brasileiros

6000 días más: evidencia neurocientífica acerca del impacto de la pobreza infantil

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