Sudden unexpected death in people with down syndrome and epilepsy: another piece in this complicated puzzle

Fish consumption in individuals with Down syndrome with seizure disorder: News for prescription

“…To evaluate the existing prospective, our research group also believes that neurologists have little exposure to and, hence, little chance to develop expertise in the management of epilepsy complications of Down syndrome (DS) [21,22]. As is well known, the occurrence of epilepsy in people with DS does not just occur in isolated cases.…”

“…As is well known, the occurrence of epilepsy in people with DS does not just occur in isolated cases. The prevalence of epilepsy in population with DS increases with age, reaching almost 50% of all patients with Down syndrome over 50 years of age [22,23]. In parallel, the bimodal distribution of seizure onset is very peculiar: 40% of patients with Down syndrome begin having seizures before the age of 1 year, and 40% experience seizures for the first time in the third decade of life [22,23].…”

“…The prevalence of epilepsy in population with DS increases with age, reaching almost 50% of all patients with Down syndrome over 50 years of age [22,23]. In parallel, the bimodal distribution of seizure onset is very peculiar: 40% of patients with Down syndrome begin having seizures before the age of 1 year, and 40% experience seizures for the first time in the third decade of life [22,23]. In these lines of reasoning, it has been shown that approximately 8% of individuals with DS have seizure disorder, which includes partial seizures (47%), infantile spasms (32%), and generalized tonic-clonic seizures (21%) [22,23].…”

“…In parallel, the bimodal distribution of seizure onset is very peculiar: 40% of patients with Down syndrome begin having seizures before the age of 1 year, and 40% experience seizures for the first time in the third decade of life [22,23]. In these lines of reasoning, it has been shown that approximately 8% of individuals with DS have seizure disorder, which includes partial seizures (47%), infantile spasms (32%), and generalized tonic-clonic seizures (21%) [22,23]. Thus, the occurrence of primarily infantile spasms predominates in the younger group; partial seizures are more frequently observed in the older group with DS; and tonic-clonic seizures seem to be equally distributed during the course of life [22][23][24].…”

“…In these lines of reasoning, it has been shown that approximately 8% of individuals with DS have seizure disorder, which includes partial seizures (47%), infantile spasms (32%), and generalized tonic-clonic seizures (21%) [22,23]. Thus, the occurrence of primarily infantile spasms predominates in the younger group; partial seizures are more frequently observed in the older group with DS; and tonic-clonic seizures seem to be equally distributed during the course of life [22][23][24]. Indeed, we must emphasize that seizures in DS may be an epiphenomenon, i.e., they may be associated with anatomical or functional alterations normally found in this condition [22,23,25].…”