Thiocolchicoside-induced liver injury

Efe, Cumali; Pürnak, Tuğrul; Özaslan, Ersan; Milanlıoğlu, Aysel

doi:10.1590/s1807-59322011000300029

Cited by 4 publications

(3 citation statements)

References 6 publications

(8 reference statements)

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“…Its use as a muscle relaxant was authorized by national procedures in several EU Member States for the treatment of painful muscular disorders, orally or by intramuscular injection [12]. Side effects of thiocolchicoside include nausea, allergy, and vasovagal reactions [11]. Liver injury has also been rarely described [11].…”

Section: Discussionmentioning

confidence: 99%

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Inadvertent intrathecal drug injection while treating low back pain: a case report and review of the literature

et al. 2023

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Background Undesired intrathecal injections represent an important subset of medical errors, albeit rare. Clinical effects depend on the type and concentration of drug(s) injected. Here we report on the case of a healthy woman with persistent low back pain, treated with a paravertebral injection of lidocaine, thiocolchicoside, and l-acetylcarnitine at an orthopedic practice. Case report A 42-year-old Caucasian woman, with no relevant past medical history, received a lumbar paravertebral injection of lidocaine, thiocolchicoside, and l-acetylcarnitine for persistent low back pain. Approximately 30 minutes after injection, she experienced quick neurological worsening. Upon arrival at the Emergency Department, she was comatose, with fixed bilateral mydriasis, trismus, and mixed acidosis; seizures ensued in the first hours; slow progressive amelioration was observed by day 6; retrograde amnesia was the only clinical relevant remaining symptom by 6 months. Conclusions To our knowledge, this is the first reported case of inadvertent intrathecal thiocolchicoside injection in an adult patient, as well as the first in the neurosurgical literature. Our experience suggests that injection therapy for low back pain should be administered in adequate settings, where possible complications may be promptly treated.

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Section: Discussionmentioning

confidence: 99%

“…Side effects of thiocolchicoside include nausea, allergy, and vasovagal reactions [11]. Liver injury has also been rarely described [11]. The European Medicine Agency also indicated that thiocolchicoside may reduce fertility in men and, if administered during pregnancy, harm fetal embriogenesis.…”

Section: Discussionmentioning

confidence: 99%

Inadvertent intrathecal drug injection while treating low back pain: a case report and review of the literature

et al. 2023

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“…The phytoconstituents that present in the Gloriosa superba show analgesic, anti-inflammatory and wound healing action in rats (John et al, 2010;Joshi et al, 2010). Colchicine, an analog of colchicoside, is also a commonly used drug, especially for rheumatic diseases (Efe et al, 2011).…”

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confidence: 99%

Methylsulfonylmethane alone or in combination with thiocolchicoside modulate autoimmune disease in rats with adjuvant arthritis

Akramas¹,

Leonavičienė

Bradūnaitė

et al. 2019

J Hellenic Vet Med Soc

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Many active anti-arthritic natural substances are revealed into the past years. The aim of study was to assess the combined efficacy of methylsulfonylmethane (MSM) with thiocolchicoside (Th) (compound MTh) and MSM alone against adjuvant-induced arthritis (AA) in rats. In the first experiment 30 rats and in the second - 21 ratswere randomly divided into 6 groups: I gr. - AA + MSM (77 mg/kg), II and V gr. - AA + diclofenac (DF), III and VI gr. - the control AA groups without treatment, IV gr. - MTh (38 mg/kg). DF (1 mg/kg) in both experiments was used as a reference drug. 6 rats were as the healthy control group. AA rats were treated from day 0 to 17. All preparations were suspended in 0.5 ml of 1℅ starch gel and injected orally 5 days a week. Body weight and joint swelling were monitored 3 times a week. Development of polyarthritis, blood indices, pro-/antioxidant activity and pro-inflammatory cytokines in blood serum, and histopathology of the liver and paw were assessed at the end of experiment. MSM significantly decreased joint swelling on days 3 and 13. MTh in twice lower dose more markedly suppressed joint swelling and also significantly reduced the changes in soft periarticular tissues, synovium and cartilage as compared to the control AA group. Both preparations alleviated infiltration with inflammatory cells and synovial proliferation, as well as protected cartilage destruction and decreased pannus formation. MSM and MTh improved the blood indices and insignificantly suppressed IL-17. They markedly decreased the level of malondialdehyde (MDA). Some anti-oxidant activity of preparations was also confirmed. No toxic effects on the liver were revealed. MSM and MTh attenuated the development of AA in rats. Combination therapy was more effective than single MSM and required the twice lower doses to receive the beneficial anti-arthritic effect. Both preparations could be the potential preventive or therapeutic candidates for the treatment of autoimmune processes in combination with other drugs.

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