Prognostic value of podoplanin expression in intratumoral stroma and neoplastic cells of uterine cervical carcinomas

Abstract

OBJECTIVE:To investigate the clinicopathological significance of podoplanin expression in the intratumoral stroma and neoplastic cells of early stage uterine cervical cancer.MATERIALS AND METHODS:A total of 143 patients with clinical stage I and IIA uterine cervical carcinomas underwent surgery between 2000 and 2007. Clinicopathological data and slides associated with these cases were retrospectively reviewed. Immunodetection of podoplanin expression in histologic sections of tissue microarray blocks was performed using the monoclonal antibody D2‐40.RESULTS:Expression of podoplanin was detected in neoplastic cells in 31/143 (21.6%) cases, with 29/31 (93.5%) of these cases diagnosed as squamous carcinoma. For all of the cases examined, the strongest signal for podoplanin expression was observed at the proliferating edge of the tumor nests. The rate of positive podoplanin expression for node‐positive cases was lower than that of node‐negative (18.9% vs. 22.6%, respectively). Furthermore, the rate of positive podoplanin expression in fatal cases was 10.5% vs. 21.6%, respectively. In 27/143 (18.8%) cases, podoplanin expression was detected in fibroblasts of the intratumoral stroma, and this expression did not correlate with patient age, clinical stage, tumor size, histologic type, depth of infiltration, or vascular involvement. Moreover, expression of podoplanin in intratumoral stroma fibroblasts was only negatively associated with nodal metastasis. A greater number of fatal cases was observed among negative intratumoral stroma fibroblasts (15.5% vs. 3.7%, respectively), although this difference was not significant.CONCLUSIONS:These preliminary results suggest that podoplanin may have a role in host‐tumor interactions and, as a result, may represent a favorable prognostic factor for squamous cervical carcinomas.

Podoplanin expression in cancer-associated fibroblasts correlates with VEGF-C expression in cancer cells of invasive ductal breast carcinoma

“…Recent studies identified podoplanin as a novel activity marker of tumor stroma of different malignancies [11][12][13][14][15][16][31][32][33]. In majority of the examined tumors we and others have shown that podoplanin expression in CAFs was associated with patients poor outcome, but in some, e.g.…”

A Comparison of Adenosquamous Carcinoma and Adenocarcinoma of the Cervix after Radical Hysterectomy

“…Radical hysterectomy followed by tailored adjuvant therapy is the most commonly performed treatment for early-stage disease, including bulky IB2 and IIA2 cervical cancer [2,3,4]. In the current guidelines, patients with adenocarcinoma (AC) or adenosquamous carcinoma (ASC) are typically treated in the same manner as those with squamous cell carcinoma (SCC) [5]. …”

Valor prognóstico da microdensidade vascular linfática intratumoral e da expressão neoplásica de podoplanina em carcinomas escamosos vulvares

“…Neste estudo não pudemos identificar nenhuma associação da podoplanina com DVL ou com as características clínico-patológicas estudadas. Entretanto, em estudo prévio, o nosso grupo avaliou a expressão de podoplanina em carcinomas de colo uterino e pode demonstrar uma tendência a associação entre ela e prognóstico mais favorável (37) . …”