Correlation between central corneal thickness and intraocular pressure peak and fluctuation during the water drinking test in glaucoma patients

Furlanetto, Rafael; Facio, Antonio Carlos; Hatanaka, Marcelo; Susanna, Remo

doi:10.1590/s1807-59322010001000007

Cited by 12 publications

(10 citation statements)

References 23 publications

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“…Under physiological circumstances, when individuals are given 1 L of water to drink rapidly, osmotic dilution inhibits vasopressin release, thus initiating diuresis, with the fluid rapidly leaving the system as urine. IOP peaks detected during the WDT predict the peaks observed during a 24‐h diurnal tension curve . Regulation of IOP after water drinking has been shown to relate to factors affecting aqueous drainage.…”

Section: Search Strategymentioning

confidence: 75%

“…In effect, the WDT is able to reveal dysfunction of the conventional outflow system. However, there appears to be no strong correlation between central corneal thickness and WDT results …”

Section: Search Strategymentioning

confidence: 92%

“…IOP peaks detected during the WDT predict the peaks observed during a 24-h diurnal tension curve. 127 Regulation of IOP after water drinking has been shown to relate to factors affecting aqueous drainage. Water drinking fails to create a bloodocular pressure gradient and is independent of active bicarbonate pumping.…”

Section: Disorders Of the Optic Nervementioning

confidence: 99%

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Hydration, fluid regulation and the eye: in health and disease

Sherwin

Kokavec

Thornton

2015

Clinical Exper Ophthalmology

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Variation in systemic hydration status, namely chronic systemic hypohydration or dehydration, can influence the development of several chronic non-ophthalmic diseases. Owing to the eye's high water content and unique system of fluid regulation, we hypothesized that hydration status may affect the eye in health and disease states. Therefore, we performed a systematic review of the current evidence implicating changes in hydration and their association with ocular physiology and morphological characteristics. We also reviewed relevant clinical correlations of changes in hydration and major common eye diseases. Our findings suggest that systemic hydration status broadly affects a variety of ocular pathophysiologic processes and disease states. For example, dehydration may be associated with development of dry eye syndrome, cataract, refractive changes and retinal vascular disease. On the other hand, excessive hydration is associated with some ocular diseases. Tear fluid osmolarity may be an effective marker of systemic hydration status. Recent studies implicate chronic renin-angiotensin-aldosterone system activation in the pathogenesis of diabetic retinopathy and glaucoma but also suggest its antagonism may be a useful therapeutic target. Our findings indicate that assessment of hydration status may be an important consideration in the management of patients with chronic eye diseases and undergoing eye surgery. Further research investigating the role of acute and chronic changes in hydration in individuals with and without ocular disease is warranted.

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Section: Search Strategymentioning

confidence: 75%

“…In effect, the WDT is able to reveal dysfunction of the conventional outflow system. However, there appears to be no strong correlation between central corneal thickness and WDT results …”

Section: Search Strategymentioning

confidence: 92%

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Hydration, fluid regulation and the eye: in health and disease

Sherwin

Kokavec

Thornton

2015

Clinical Exper Ophthalmology

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“…Central corneal thickness was not measured in this study. Although the lack of this information could influence the classification of participants into OH or OAG groups, a previous study has demonstrated that WDT results are not influenced by corneal thickness . Moreover, even if misclassification occurred, it did not affect the analysis of reproducibility given the within‐subject comparison at two different time points using paired analyses.…”

Section: Discussionmentioning

confidence: 99%

Reproducibility of intraocular pressure peak and fluctuation of the water‐drinking test

Hatanaka

Alencar

Moraes

et al. 2012

Clinical Exper Ophthalmology

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“…26,27 Çalışmamıza benzer olarak, su içme testinin kornea kalınlığı üzerine etkisi anlamlı bulunmamış-tır. 28,29 Glokom tedavisinin temel amacı, hedef GİB'in belirlenmesidir. Bazı hastalarda, GİB normal sınır-lara düşürülse bile progresyon devam edebilir.…”

Section: Gereç Ve Yöntemlerunclassified

The Effect of Water Drinking Test on the Corneal Biomechanical Properties and Central Corneal Thickness in Patients with Glaucoma Suspect

Kaya¹,

Dönmez²,

Arıkan³

et al. 2016

Turkiye Klinikleri J Ophthalmol

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lokom hastalığı, progresif bir optik nöropatidir ve uygun tedavi edilmediğinde geri dönüşümsüz görme kaybına neden olur.1 Bilinen en önemli risk faktörü yüksek göz içi basıncı (GİB) olmakla birlikte, Turkiye Klinikleri J Ophthalmol 2016;25(4) 225 Glokom Şüphesi Olan Hastalarda Su İçme Testinin Korneanın Biyomekanik Özellikleri ve Santral Kornea Kalınlığı Üzerine Etkisi Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmada, glokom şüphesi olan hastalarda su içme testinin korneanın biyomekanik özellikleri ve santral kornea kalınlığı üzerine etkisinin değerlendirilmesi amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Glokom şüphesi olan 31 hastanın 31 gözü çalışmaya alındı. Goldmann aplanasyon tonometresi ile göz içi basıncı (GİB) ve ultrasonik pakimetri ile santral kornea kalınlıklarının (SKK) bazal ölçümleri yapıldı. Oküler Cevap Analizörü ile korneal kompanse göz içi basıncı (GİBkk), Goldmann ile uyumlu göz içi basıncı (GİBg), korneal direnç faktörü (KDF) ve korneal histerezis (KH) değerleri ölçüldü. Tüm ölçümler her hasta için başlangıçta ve 5 dk içinde 1 L su içmelerinin ardından 15 dk'lık aralarla üç defa uygulandı. B Bu ul lg gu ul la ar r: : Çalışma populasyonunun ortalama yaşı 57,9±7,4 (aralık, 43-67) yıldı. Hastaların GİBkk, GİBg ve KH ölçümlerinde, su içme testinin 15, 30 ve 45. dakikalarında bazal ölçümlere göre istatistiksel olarak anlamlı artış saptandı (p<0,001). Hastaların KDF ölçümlerinde, su içme testinden sonra bazal değere göre 15, 30 ve 45. dakikalarda anlamlı düşme saptandı (p=0,022). Su içme testinden sonra SKK ölçümlerinde istatistiksel anlamlı değişiklik saptanmadı (p=0,466). S So on nu uç ç: : Glokom şüphesi olan hastalarda su yükleme testi GİB değerlerinde anlamlı artışa ve kornea biyomekanik özelliklerinde değişikliğe neden olmaktadır. Ancak, testin santral kornea kalınlığı üzerine herhangi bir etkisi olmamaktadır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Göz hipertansiyonu; kornea A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : It is aimed to evaluate the influence of water drinking test (WDT) on corneal biomechanical factors and central corneal thickness (CCT) in patients with glaucoma suspect. M Ma at te e--r ri ia al l a an nd d M Me et th ho od ds s: : Thirty-one eyes of 31 patients with suspected glaucoma were enrolled in this study. Baseline evaluation of intraocular pressure with Goldmann applanation tonometer (GAT) and CCT with ultrasonic pachymeter were performed. Corneal-compensated intraocular pressure (IOPcc), Goldmann-correlated IOP (IOPg), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured by ocular response analyzer (ORA). Such measurements were performed at baseline and 3 times with 15 minutes intervals after drinking 1 liter of water in 5 minutes for each participants. R Re e--s su ul lt ts s: : The mean age of study population was 57.9±7.4 (range, 43-67 years) years. A statistically significant increase in IOPcc, IOPg and CH was found at 15, 30 and 45 minutes of WDT when compared to baseline scores (p<0.001). I...

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Correlation between central corneal thickness and intraocular pressure peak and fluctuation during the water drinking test in glaucoma patients

Cited by 12 publications

References 23 publications

Hydration, fluid regulation and the eye: in health and disease

Hydration, fluid regulation and the eye: in health and disease

Reproducibility of intraocular pressure peak and fluctuation of the water‐drinking test

The Effect of Water Drinking Test on the Corneal Biomechanical Properties and Central Corneal Thickness in Patients with Glaucoma Suspect

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