Growth of very low birth weight infants fed with milk from a human milk bank selected according to the caloric and protein value

Abstract

OBJECTIVE:To describe growth and clinical evolution of very low birth weight infants fed during hospital stay with milk from a human milk bank according to the caloric-protein value.METHOD: Forty very low birth weight infants were included: 10 were fed milk from their own mothers (GI), and 30 (GII) were fed human milk bank . 700 cal/L and 2 g/dL of protein. Growth curves were adjusted using nonlinear regression to the measured growth parameters.RESULTS: full enteral diet was reached in 6.3 days by GI and in 10.8 by GII; a weight of 2 kg was reached in 7.3 weeks for GI and in 7.8 for GII. In GI, 3/10 (33.3%) and in GII, 7/30 (23.3%) developed sepsis. Necrotizing enterocolitis did not occur in GI, but in 3/30 (10.0%) in GII. GI presented with urinary calcium . 4 mg/L in 1/10 (10.0%), urinary phosphorus (P u ) ,1 mg/L in 10/10 (100%), and Ca/Cr .0.6 ratio in 1/10 (10.0%) of the cases; in GII, no children presented alterations of the urinary calcium or the Ca and Cr ratio, and P u was ,1 mg/L in 19/30 (63.3%). In terms of growth the 50 th percentile for GI was a weight gain of 12.1 g/day (GI) vs. 15.8 g/day (GII), a length gain of 0.75 cm/week (GI) vs. 1.02 cm/week (GII), and a head circumference gain of 0.74 cm/week (GI) vs. 0.76 cm/week (GII). CONCLUSIONS:Human milk bank allowed a satisfactory growth and good clinical evolution for very low birth weight infants.

A systematic review and meta-analysis of the nutrient content of preterm and term breast milk

“…Attempts were made to contact authors of nine studies, we received replies from four, but no additional information was received for the meta-analyses. Ninety-nine studies were excluded for reasons provided in Figure 1 : no original data/review articles [ 25 - 39 ], studies performed in developing countries [ 40 - 48 ], no numerical results [ 49 - 59 ], not 24-hour milk collection/pooled milk (required only for energy and fat contents) [ 7 - 9 , 60 - 70 ], no report of macro/micronutrient contents [ 36 , 71 - 107 ], did not report time frames used in the meta-analyses [ 108 - 116 ], other [ 117 , 118 ]. Energy was estimated in 11 studies using bomb calorimetry [ 11 , 12 , 18 , 119 - 126 ] and in five studies by calculation using values for the energy contributions from fat, protein, and carbohydrate [ 6 , 19 , 22 , 121 , 127 ].…”

O papel do banco de leite humano na promoção da saúde materno infantil: uma revisão sistemática

“…Os artigos selecionados, bem como as principais características dos estudos, são descritos nos Quadros 1 e 2. Dos estudos listados, observou-se que 27,3% (n = 3) tratam do perfil das doadoras de leite humano 7,10,11 ; 18,2% (n = 2) avaliaram o impacto da orientação de profissionais do Banco de Leite Humano na manutenção do aleitamento materno para crianças prematuras internadas 12,13 ; 18,2% (n = 2) pesquisaram o ganho de peso em bebês prematuros alimentados com leite de banco 14,15 ; 27,3% (n = 3) evidenciaram o apoio ao aleitamento materno por meio das ações do ban-co de leite humano [16][17][18] ; 9% (n = 1) mostrou os fatores que levaram à doação de leite humano 19 .…”

“…Em 18,2% (n = 2) dos artigos, foi verificado o ganho de peso dos recém-nascidos em uso do leite materno ou de leite humano pasteurizado de banco 14,15 . Importantes resultados no ganho de peso de bebês prematuros em uso de leite materno e humano de banco de leite foi encontrado no estudo de Silva et al 15 .…”

“…Na referida pesquisa foi possível identificar maior ganho de peso ponderal em prematuros com extremo baixo peso ao nascimento em uso de leite misto (leite materno exclusivo da mãe e leite do BLH), seguido de neonatos com muito baixo peso ao nascer em uso de leite materno exclusivo da própria mãe. Ainda com relação ao ganho de peso em prematuros, Aprile et al 14 descreveram o crescimento e a evolução clínica de lactentes de muito baixo peso alimentados durante a internação hospitalar com leite de um banco de leite humano. Neste estudo foram incluídos 40 bebês com muito baixo peso ao nascer: 10 foram alimentados com leite de suas próprias mães e 30 foram alimentados com o banco de leite humano.…”

Pediatrics in Clinics: Highlights

“…Aprile et al (16) described the growth and clinical evolution of 30 very low birth weight infants fed during hospital stay with milk from a human milk bank according to the caloric-protein value vs. 10 fed milk from their own mothers and conclude that milk from the human bank allowed a satisfactory growth and good clinical evolution for these infants. Balaban et al (17) investigated whether early weaning constitutes a risk factor for overweight at preschool age and identified other factors that affect this association through a case-control study of 366 children aged 2 to 6 years (176 boys and 190 girls) from three Brazilian cities.…”