Distinctive Tomographic Abnormalities of the Craniocervical Region in a Patient with Osteogensis Imperfecta Type IV B

Kaissi, Ali Al; Klaushofer, Klaus; Grill, Franz

doi:10.1590/s1807-59322010000600014

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…In addition to the clinical signs and symptoms, numerous imaging diagnosis methods have been suggested for the diagnosis or confirmation of pathology in the basilar region. Although the actual diagnosis is nowadays most accurately carried out from computed tomography (CT) or magnetic resonance imaging (MRI); lateral skull radiographs are still recommended for screening purposes as a simple, low cost, and low radiation method for patients at risk ( 17 , 27 - 30 ).…”

Section: Introductionmentioning

confidence: 99%

A cephalometric method to diagnosis the craniovertebral junction abnormalities in osteogenesis imperfecta patients

Ríos-Rodenas¹,

Nova-García

et al. 2015

J Clin Exp Dent

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Osteogenesis imperfecta (OI) is a hereditary bone fragility disorder that in most patients is caused by mutations affecting collagen type I. Their typical oral and craneofacial characteristics (Dentinogenesis imperfecta type I and class III malocclusion), involve the dentist in the multidisciplinary team that treat these patients. It is usual to perform lateral skull radiographs for the orthodontic diagnosis. In addition, this radiograph is useful to analyse the junctional area between skull base and spine, that could be damaged in OI. Pathology in the craneovertebral junction (CVJ) is a serious complication of OI with a prevalence ranging from rare to 37%. To diagnosis early skull base anomalies in these patients, previously the neurological symptoms have been appear, we make a simple cephalometric analysis of the CVJ. This method has four measurements and one angle. Once we calculate the values of the OI patient, we compare the result with the mean and the standard deviations of an age-appropriate average in healthy controls. If the patient has a result more than 2,5 SDs above the age-appropriate average in healthy controls, we should to refer the patient to his/her pediatrician or neurologist. These doctors have to consider acquiring another diagnostic images to be used to determine cranial base measurements with more reliability. Thereby, dentists who treat these patients, must be aware of the normal radiological anatomy of the cervical spine on the lateral cephalogram. Key words:Osteogenesis imperfecta, craniovertebral junction, cephalometric.

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Section: Introductionmentioning

confidence: 99%

A cephalometric method to diagnosis the craniovertebral junction abnormalities in osteogenesis imperfecta patients

Ríos-Rodenas¹,

Nova-García

et al. 2015

J Clin Exp Dent

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Analysis of Craniocervical Abnormalities in Osteogenesis Imperfecta during Growth

De Nova-García,

Sola,

Burgueño-Torres

2024

Applied Sciences

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Osteogenesis Imperfecta (OI) is a genetic disease characterized by osteopenia and bone fragility in which the craniocervical junction is also affected. This is of special relevance due to the high prevalence in anomalies described in the literature as follows: basilar invagination, basilar impression, and platybasia. Methods. We analyzed 19 lateral skull radiographs and 14 magnetic resonance images (MRIs) of 28 patients with OI in which eight linear and five angular measurements were plotted to determine the existence of craniocervical junction anomalies and compare them with 38 lateral skull radiographs and 28 MRIs performed on age-matched healthy controls. Results. From the reference values obtained from the control sample for each age group, we established the limit value at which pathology could be suspected. Some of the variables studied showed a clear trend associated with growth. More than half of the patients (60.71%) presented an anomaly in the skull base. Conclusions. According to the diagnostic criteria used and taking +2.5 SD as the limit value, 10.71% of the patients had basilar invagination, 35.71% had basilar impression, and 39.29% had platybasia, the latter being the most common finding.

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Distinctive Tomographic Abnormalities of the Craniocervical Region in a Patient with Osteogensis Imperfecta Type IV B

Cited by 2 publications

References 14 publications

A cephalometric method to diagnosis the craniovertebral junction abnormalities in osteogenesis imperfecta patients

A cephalometric method to diagnosis the craniovertebral junction abnormalities in osteogenesis imperfecta patients

Analysis of Craniocervical Abnormalities in Osteogenesis Imperfecta during Growth

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