Thalamic nuclear abnormalities as a contributory factor in sudden cardiac deaths among patients with schizophrenia

Schmitt, Andrea; Cysneiros, Roberta Monterazzo; Arida, Ricardo Mário; Cavalheiro, Ésper A.; Gattaz, Wagner F.

doi:10.1590/s1807-59322010000500012

Cited by 7 publications

(2 citation statements)

References 85 publications

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“…In this regard, remains unknown the exact pathophysiological cause of sudden unexpected death in schizophrenia, however, it has been suggested that cardiac arrhythmia plays a potential role [5], [9] . There is no doubt that people with schizophrenia are at high risk for cardiovascular disease, and some atypical antipsychotics may be associated with cardiovascular adverse events (e.g., QT interval prolongation), suggesting that this could lead to torsade the points or sudden death [5], [10], [11] .…”

Section: Expert Hypothysismentioning

confidence: 99%

“…There is no doubt that people with schizophrenia are at high risk for cardiovascular disease, and some atypical antipsychotics may be associated with cardiovascular adverse events (e.g., QT interval prolongation), suggesting that this could lead to torsade the points or sudden death [5], [10], [11] . Moreover, antipsychotic medications can induce metabolic adverse effects causing abnormalities in glucose and lipid metabolism.…”

Section: Expert Hypothysismentioning

confidence: 99%

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When the clock stops ticking, metabolic syndrome explodes. Does omega-3 is able to disarm this bomb?

Scorza¹,

Cysneiros²,

Almeida³

et al. 2014

Mol Cell Epilepsy

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Schizophrenia is not a single disease entity since there are multiple etiological factors and pathophysiological mechanisms involved however with common phenotypic characteristics. Furthermore, it is associated with increased mortality and reduced life expectancy. In this scenario, the cardiovascular diseases are the most common cause of death. People with schizophrenia are at high risk of metabolic syndrome once some antipsychotics drugs frequently cause weight gain, dyslipidemia and diabetes mellitus and these facts together are important risk factors for cardiovascular diseases and even to the occurrence of sudden death in this specific population. The long-term effect of metabolic syndrome on overall mortality and cardiovascular mortality is a fact that should not be neglected among individuals com schizophrenia. We debate that supplementation with omega-3 fatty acids is extremely beneficial for people with schizophrenia, since it is clearly demonstrated that this polyunsaturated fatty acid has a positive action in both the metabolic syndrome as in cardiovascular dysfunctions. We suggest that omega-3 supplementation must be considered in the treatment of people with schizophrenia aiming at reducing risk factor for sudden unexpected death.

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Section: Expert Hypothysismentioning

confidence: 99%

Section: Expert Hypothysismentioning

confidence: 99%

When the clock stops ticking, metabolic syndrome explodes. Does omega-3 is able to disarm this bomb?

Scorza¹,

Cysneiros²,

Almeida³

et al. 2014

Mol Cell Epilepsy

View full text Add to dashboard Cite

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THE THALAMUS AND Parkinson's Disease: The Uncertainty of It All

Scorza

Almeida

Scorza

et al. 2020

Magnetic Resonance Imaging

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We enjoyed reading the recent article in JMRI entitled, "Structural and Functional Thalamic Changes in Parkinson's Disease With Mild Cognitive Impairment" by Li et al. 1 The authors demonstrated specific thalamic volume loss and functional connectivity alterations in patients with Parkinson's disease (PD), which probably plays an important role in the clinical characteristics and also in the patterns of disease progression. 1 Considering that PD is now widely recognized to be a multisystem disorder, we would like to add some thoughts that may open the debate about the possible role of the thalamus on sudden unexpected death in PD (SUDPAR). PD is one of the most frequent age-related neurodegenerative disorders, has no cure, and the mortality of PD is higher when compared to the general population. 2-4 Thus, a series of recent studies suggested that SUDPAR could contribute to the mortality in PD. 3,4 SUDPAR could be defined as the unexpected death of a PD patient without any satisfactory cause of death as determined by autopsy. 3,4 Potential risk factors of SUDPAR are age at onset, disease duration, gender, motor severity, sleep disorder, concomitant cardiac and pulmonary disease, and polypharmacy. 3,4 The precise pathomechanisms of SUDPAR remain unknown; however, cardiac involvement is assumed to play a "direct" role, since there is evidence associating PD with structural and functional heart change. 3,5 An issue not deeply explored is the existence of a "cerebral" focus that triggers SUDPAR. Although the presence of brain structural abnormalities in PD is well demonstrated, 1 only in the last decade have important advances been made in understanding the cerebral structures directly or indirectly affecting the heart, called "cardiovascular" areas. 6 Since stimulation of certain cerebral areas can lead to morphological and functional cardiovascular alterations, 6-8 we believe that this issue should be further investigated. The first clue in this direction was described in the late 1970s, demonstrating that bilateral injection of kainic-acid into the lateral posterior thalamic nuclei (LP) of rats led to myocardial necrosis, suggesting that this specific nucleus has a direct relationship with the cardiovascular system. 7,8 Later accumulated experimental and clinical evidence demonstrated that some structural changes are potentially associated with sudden death in epilepsy (SUDEP) and volume reduction of the posterior thalamus appears to be a risk factor for SUDEP. 7,9 Likewise, the same findings regarding LP were also described in individuals with schizophrenia. 8 Importantly, it is already known that the pathology in the thalamus itself contributes to the abnormal neural activity characteristic of PD and this role of the thalamus in the course of PD correlates with its extensive projection to the cortex and other areas, including the basal ganglia, cerebellum, and hippocampus. 10 As some of the structures connected with the thalamus are considered potential biomarkers for SUDEP, 9 it is quite reasonable to consider ...

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Children with Congenital Heart Diseases Exhibit Altered Deep Gray Matter Structures

Forkert,

MacEachern,

Duh

et al. 2024

Clin Neuroradiol

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Thalamic nuclear abnormalities as a contributory factor in sudden cardiac deaths among patients with schizophrenia

Cited by 7 publications

References 85 publications

When the clock stops ticking, metabolic syndrome explodes. Does omega-3 is able to disarm this bomb?

When the clock stops ticking, metabolic syndrome explodes. Does omega-3 is able to disarm this bomb?

THE THALAMUS AND Parkinson's Disease: The Uncertainty of It All

Children with Congenital Heart Diseases Exhibit Altered Deep Gray Matter Structures

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