Effects of the Modification of the Aortic Bifurcation Geometry: A Technical Note Regarding a Novel Model for Experimental Atherosclerotic and Aneurysmatic Lesions

Ortiz-Velázquez, Rogelio Iván; Caldas, José Guilherme Mendes Pereira; Lobo, Bruno Carmello Rocha; Santos-Franco, Jorge Arturo; Mercado-Pimentel, Rodrigo; Revuelta, Rogelio

doi:10.1590/s1807-59322010000300018

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…The outcomes show an increase in the thicknesses of the tunica intima and tunica media with age, and these changes are physiological. Aging causes arterial wall remodeling, which leads to luminal expansion, thickening of the tunica intima and tunica media, increased resistance of the vascular wall, reduction of the regenerative capacity of the endothelium and an increase in the endothelial cell apoptosis rate ( 20 , 21 ). Our data confirm additional findings.…”

Section: Discussionmentioning

confidence: 99%

Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation

Ferraz¹,

Nascimento²,

Rorato³

et al. 2012

Clinics

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OBJECTIVES:To describe the morphological features of atherosclerosis in the aortas of autopsied patients (ranging from young adults to the elderly), thus providing new tools for a more sensitive morphological evaluation.METHOD:We collected 141 aorta samples. We assessed the macroscopic degree of atherosclerosis, thickness of the intima and media, lipid and collagen depositions in the intima, and the infiltration of mast cells into the layers of the aorta. We correlated the findings with gender, age, race and cause of death.RESULTS:The degree of atherosclerosis was significantly higher in the elderly. The aorta was thicker in the elderly and in cases with a cardiovascular cause of death. The thickness of the intima was significantly greater in the elderly, in males and in cases with a cardiovascular cause of death. The lipid content in the intima of the aorta was significantly higher in Caucasians. Older people and men had a significantly higher number of mast cells.CONCLUSION:A macroscopic evaluation is a good indicator of the severity of atherosclerosis, but a more detailed analysis, namely evaluating the thickness of the layers of the aorta and the number of mast cells, may further elucidate the changes in the constituents of this vessel.

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Section: Discussionmentioning

confidence: 99%

Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation

Ferraz¹,

Nascimento²,

Rorato³

et al. 2012

Clinics

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Morphological and Histopathological Study of Autopsied Patients with Atherosclerosis and HIV

Oliveira

Torquato

Tsuji

et al. 2021

CHR

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Background: Chronic infection by HIV evolves with a vascular inflammatory action causing endothelial dysfunction. The action of the virus as well as the side effects of antiretroviral drugs contributes to the progression of cardiovascular diseases. The present study aimed to evaluate the percentage of collagen fibers and the density of mast cells, chymase and tryptase, in aortas of patients with and without HIV, and also patients with and without atherosclerosis. Methods: Aortic fragments were obtained from autopsied patients aged 22-69 years, selected regardless of cause of death or underlying disease. The samples were divided into four groups, (1) Group with HIV and with atherosclerosis; (2) Group with HIV and without atherosclerosis; (3) Group without HIV and with atherosclerosis; (4) Group without HIV and without atherosclerosis (Control). The percentage of collagen fibers was analyzed in the intima-media layer and the density of mast cells were analyzed in all aortic layers. Graphpad Prism 5.0® software was used for statistical analysis. Results: There were more collagen fibers in HIV patients, with or without atherosclerosis. The group with HIV and atherosclerosis presented a higher density of chymase and tryptase mast cells. The correlation between collagen fibers and age was negative in the non-HIV group and with atherosclerosis. Conclusion: The inflammatory process resulting from HIV infection may be relevant in the alteration of aortic collagen fibers and in triggering or accelerating atherosclerosis. The study is important because HIV patients have increased risks for the development of cardiovascular diseases, and follow-up is necessary to prevent such diseases.

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Effects of the Modification of the Aortic Bifurcation Geometry: A Technical Note Regarding a Novel Model for Experimental Atherosclerotic and Aneurysmatic Lesions

Cited by 2 publications

References 6 publications

Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation

Correlation of lifetime progress of atherosclerosis and morphologic markers of severity in humans: new tools for a more sensitive evaluation

Morphological and Histopathological Study of Autopsied Patients with Atherosclerosis and HIV

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