Churg-Strauss Syndrome and Active Chronic Hepatitis B Virus Infection: Coincidence or Association?

Domiciano, Diogo Souza; Shinjo, Samuel Katsuyuki; Levy‐Neto, Maurício

doi:10.1590/s1807-59322010000300015

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…The results of tests for HBV antibodies (HBsAb, HBeAb, and HbcAb) were positive, although for HBV-DNA were negative and for RF were positive. While our patient probably did not have a chronic HBV infection, this has been associated with CSS in rare cases (14). Moreover, increased RF may be found in about 86% of patients with CSS, although it is unrelated to CSS etiology (15).…”

mentioning

confidence: 63%

Clinicopathological Features of Churg-Strauss Syndrome With Severe Nerve Degeneration: A Case Report

Xiang

Zhao

et al. 2012

Medicina

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Churg-Strauss syndrome (CSS) is a rare autoimmune vasculitis of unknown etiology that involves small- and medium-sized blood vessels. Its onset is thought to be associated with adult-onset asthma, and vasculitis typically involves vessels in the lungs. However, due to increased blood and tissue eosinophilia, vasculitis may result in the involvement multiple systems of (neurological, skin, etc.). We report a case of CSS with manifestations that included skin purpura and severe peripheral nerve degeneration in a 56-year-old woman with a recent history of asthma. After the treatment with methylprednisolone and standard immunosuppressive therapy, her rashes resolved, there were no acute asthma attacks, and the numbness in her lower limbs improved.

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confidence: 63%

Clinicopathological Features of Churg-Strauss Syndrome With Severe Nerve Degeneration: A Case Report

Xiang

Zhao

et al. 2012

Medicina

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“…In both reports the role of HCV in systemic vasculitis was underlined. Another case presentation discussed concurrent Churg-Strauss syndrome and HBV in an ANCA positive patient [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Antineutrophil Cytoplasmic Antibody Frequency in Chronic Hepatitis B Patients

et al. 2014

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Background. Chronic hepatitis B (CHB) is a viral disease, common across the world, and associated with several extraintestinal manifestations including vasculitis. Antineutrophil cytoplasmic antibodies (ANCAs) are sensitive and specific markers for vasculitides. There is limited data available in the literature on whether ANCA formation is stimulated by CHB infection. In the present study we aimed to identify the frequency of ANCA in CHB patients. Methods. A total of 174 subjects were included in the study (87 CHB patients, 87 control subjects). Perinuclear-ANCA (P-ANCA), cytoplasmic-ANCA (C-ANCA), myeloperoxidase ANCA (MPO-ANCA), and proteinase 3-ANCA (PR3-ANCA) were studied. IFA was used for P-ANCA and C-ANCA assays, and ELISA was used for MPO-ANCA and PR3-ANCA assays. Results. ANCA positivity was high in both groups (31% in the CHB group and 26% among controls). There were no significant differences between the groups for P-ANCA and MPO-ANCA (P = 0.6 and P = 0.6, resp.). Frequency of borderline positive C-ANCA and all positive PR3-ANCA (positive + borderline positive) was significantly higher in the CHB group (P = 0.009 and P = 0.005, resp.). Conclusions. In the present study, the frequency of ANCA was high in both groups. The CHB group had a relatively higher frequency of ANCA positivity compared to controls. Borderline positive C-ANCA and positive PR3-ANCA were significantly higher in the CHB group. These results suggest that ANCA may have a high prevalence in Turkey. Patients with CHB should be evaluated particularly for C-ANCA and PR3-ANCA in the presence of vasculitic complaints and lesions.

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“…Although viral induction of host autoantibodies reactive to vasculature was postulated, anti-endothelial cell antibodies (AECA) implicated in a number of vasculitis (including PAN) are rarely found in HBV patients, and they are similar among HBV-infected patients with or without PAN as well as among healthy controls [24,25]. There have been anecdotal reports of chronic HBV infection associated with other forms of vasculitis such as eosinophilic granulomatosis with polyangiitis (GPA) [26,27] or HBV vaccination preceding the onset of vasculitis [28]. It remains unclear whether these reports are coincidental or causal.…”

Section: Pathogenesismentioning

confidence: 99%