Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients

Erdem, Fazile Hatipoğlu; Karatay, Saliha; Yıldırım, Kadir; Kızıltunç, Ahmet

doi:10.1590/s1807-59322010000200009

Cited by 30 publications

(35 citation statements)

References 27 publications

(27 reference statements)

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“…e signi cantly decreased PON1 activity observed in this study may re ect the increased consumption of antioxidant activity resulting from chronic in ammation and oxidant stress. Contrary to our results, Erdem et al reported no di erence in PON or arylesterase levels between AS patients and controls, but this may have been the result of di erent study techniques and/or shorter disease duration [34]. On the other hand, PON1 activity was found to be negatively correlated with disease duration, suggesting that PON1 is consumed as the disease progresses and chronic in ammation continues, which possibly is indicative of increased LDL oxidation and subsequent atherosclerosis.…”

Section: Discussioncontrasting

confidence: 99%

Carotid intima-media thickness and paraoxonase activity in patients with ankylosing spondylitis

Çeçe

Yazgan²,

Karakaş³

et al. 2011

CIM

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Purpose: e risk of atherosclerosis is increased in several rheumatological disorders, but any such risk remains unproven for ankylosing spondylitis. Since carotid intima-media thickness is an indicator of early atherosclerosis, and the paraoxonase (PON1) enzyme has antioxidant activity to prevent LDL oxidation, we aimed to identify: 1) the relationship between carotid intima-media thickness (CIMT) and serum paraoxonase (PON1) activity in ankylosing spondylitis (AS) patients; and 2) the possible di erences in CIMT in AS patients versus age-matched, healthy controls.Methods: Forty-ve AS patients (36.8±9.8 years, 36 males, 9 females) and 30 controls (35.9±10.2 years, 23 males, 7 females) were recruited consecutively. Serum PON1 activity and CIMT were measured. e Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Radiologic Index (BASRI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were used to identify relationships between these clinical indices and levels of CIMT and PON1.Results: Mean CIMT was signi cantly increased in AS patients relative to controls (0.49±0.06 mm vs. 0.59±0.07 mm; p < 0.0001). Conversely, serum PON1 activity was decreased (199.1±60.3 U/L vs. 96.7±29 U/L; p < 0.0001). PON1 activity was negatively correlated with CIMT (r = -0.557, p = 0.0001). Disease duration was positively correlated with CIMT (r = 0.542, p = 0.0001) and negatively correlated with PON1 (r = -0.649, p = 0.0001). On multivariate analysis, disease duration and serum PON1 activity were found to be independent predictors of CIMT (R 2 = 0.687, p = 0.0001). Conclusions:In conclusion, signi cantly increased CIMT and decreased PON1 activity suggest a relationship between atherosclerosis and AS: a relationship that is strongly correlated with disease duration.

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Section: Discussioncontrasting

confidence: 99%

Carotid intima-media thickness and paraoxonase activity in patients with ankylosing spondylitis

Çeçe

Yazgan²,

Karakaş³

et al. 2011

CIM

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“…PON1 (paraoxonase activity, EC 3.1.8.1) was named after its ability to hydrolyze the organophosphate substrate paraoxon, that is the toxic metabolite of the insecticide parathion [5]. It is produced by the liver and is associated with HDL particles and is known to modulate the antioxidant and anti-inflammatory role of high density lipoprotein (HDL) [6] [7]. Paraoxonase (PON) family consists of PON1, PON2, and PON3 located on chromosome 7q21,3-22.1.…”

Section: Introductionmentioning

confidence: 99%

“…[5] PON1 is a calcium dependent esterase associated exclusively with HDL [8]. PON1 has 3 known enzymatic molecules including PON, arylesterase and dyazoxonase [7]. Serum PON1 also hydrolyzes proinflammatory oxidized lipids which is present in oxidized low density lipoprotein and ruins their atherogenic characteristics [5].…”

Section: Introductionmentioning

confidence: 99%

“…These enzymes play a role in decreasing oxidative stress. PON1 is an important endogenous free radical scavenging system in the human body [7]. Psoriasis is associated with increased risk of cardiovascular abnormalities, hypertension, dyslipidemia, atherosclerosis, diabetes mellitus (type 2), obesity, chronic obstructive pulmonary disease (COPD), cerebral stroke, osteoporosis, cancer and depression.…”

Section: Introductionmentioning

confidence: 99%

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Study of Lipid profile and Paraoxonase-1 Activity in Psoriatic patients

Arora¹,

Kumar²,

Mahat³

et al. 2015

Int J of Biomed & Adv Res

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Background: Psoriasis is a common recurrent disease of skin characterised by excessive cell proliferation and incomplete differentiation in lesional epidermis. Aim: The present study was aimed to determine lipid parameters and paraoxonase activity in psoriatic patients. Methods: The study included 100 subjects of age group 30-60 years, out of which 50 were patients of psoriasis (Case group) and rest 50 were normal healthy individuals of same age group (Control group). Result: Our study showed significant increase (p<0.001) in the levels of Cholesterol, Triglyceride, LDL and VLDL in patients of psoriasis as compared to control group. Also, we found significant decreased levels of serum HDL and PON-1 in psoriatic patients as compared to control group. Conclusion: Our study concludes that altered lipid profile and paraoxonase may be responsible for the higher prevalence of systemic complication such as metabolic and cardiovascular diseases.

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“…Paraoxonase-1 hydrolyzes organophosphates such as paraoxon, hydrolyzes aromatic esters such as phenylacetate, and also decreases the accumulation of lipid peroxidation products. Serum PON1 acts in conjunction with ARE to function as a single enzyme having lipophilic antioxidant characteristics [10] . To our best knowledge, PON1 and ARE activities in cow plasma has not been evaluated during the estrous cycle until now.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Estrous Cycle on Oxidant and Antioxidant Parameters in Dairy Cows

Aydılek¹,

Varışlı²,

Selek³

et al. 2014

Kafkas Univ Vet Fak Derg

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Reactive oxygen species have fundamental roles in reproductive functions. To comprehensively evaluate the relation between reactive oxygen species and infertility, physiological variations across the estrous cycle in healthy cows have to be known. For this purpose 25 healthy multiparous Holstein dairy cows having regular estrous cycles were used. The estrous cycles were synchronized by ovsynch protocol. Oxidant [lipid hydroperoxide (LOOH), total oxidant status (TOS), oxidative stress index (OSI)], antioxidant parameters [total antioxidant status (TAS), total free sulfhydryl groups (SH), ceruloplasmin (CP), paraoxonase-1 (PON1), arylesterase (ARE), uric acid (UA)], lipid profile and progesterone levels were assayed at estrus, metestrus, diestrus and proestrus stages of the estrous cycle in the plasma samples. The plasma levels of oxidant (LOOH, TOS and OSI) and antioxidant (TAS, SH and UA) parameters were significantly decreased during the luteal phase compared to the follicular phase (at proestrus and at estrus) of the estrous cycle. There was also a significant positive correlation between TAS and TOS. The activity of PON1 and ARE significantly increased only at diestrus. Levels of high density lipoprotein, low density lipoprotein and total cholesterol elevated during the follicular phase (estrus) and declined during the luteal phase. In conclusion, oxidant/antioxidant status and lipid profile were affected by cyclic changes. Moreover, antioxidant defense system showed adaptive response to increased oxidative activities by occurring parallel increases and it may indicate that there is a dynamic balance between oxidant and antioxidant status during the estrous cycle in healthy cows. Keywords: Cow, Estrous cycle, Lipid peroxide, Lipid profile, Total antioxidant status, Total oxidant status Sütçü İneklerde Östrus Siklusunun Oksidan ve Antioksidan Parametreler Üzerine Etkisi ÖzetReaktif oksijen türlerinin üreme fonksiyonları üzerinde önemli rolleri vardır. Sağlıklı süt sığırlarında reaktif oksijen türleri ve infertilite arasındaki ilişkiyi kapsamlı bir şekilde değerlendirmek için östrus siklusu boyunca reaktif oksijen türü seviyelerindeki değişimlerin bilinmesi gerekir. Bu çalışmada düzenli siklus gösteren 25 adet sağlıklı Holştayn ırkı sütçü inek kullanıldı. Östrus siklusları ovsynch protokolü ile senkronize edildi. Östrus siklusunun proöstrus, östrus, metaöstrus ve diöstrus dönemlerinde kan plazmasında oksidan parametreler [lipit hidroperoksit (LOOH), total oksidan seviye (TOS), oksidatif stres indeksi (OSI)], antioksidan parametreler [total antioksidan kapasite (TAS), total serbest sülfhidril gruplar (SH), seruloplazmin (CP), paraoksonaz-1 (PON1), arilesteraz (ARE), ürik asit (UA)], lipit profili ve progesteron seviyesi ölçüldü. Foliküler dönemle karşılaştırıldığında luteal dönemdeki plazma oksidan (LOOH, TOS, OSI) ve antioksidan (TAS, SH, UA) seviyelerinin önemli derecede düştüğü görüldü. Ayrıca TAS ve TOS değerleri arasında önemli bir pozitif korelasyon vardı. Paraoksonaz-1 ve ARE aktiviteleri sadece diöstrus ...

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Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients

Cited by 30 publications

References 27 publications

Carotid intima-media thickness and paraoxonase activity in patients with ankylosing spondylitis

Carotid intima-media thickness and paraoxonase activity in patients with ankylosing spondylitis

Study of Lipid profile and Paraoxonase-1 Activity in Psoriatic patients

The Effect of Estrous Cycle on Oxidant and Antioxidant Parameters in Dairy Cows

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