Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?

Lobo, Vera Lucia Rodrigues; Júnior, José Maria Soares; Simões, Manuel de Jesus; Simões, Ricardo Santos; Lima, Geraldo Rodrigues de; Baracat, Edmund Chada

doi:10.1590/s1807-59322008000400019

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…Like human endometriotic lesions, those obtained from mice and rats are cyst like structures containing endometrial glands and stroma, contain numerous adhesions in the peritoneal cavity, often have hemosiderin laden macrophages present, and the growth is estrogen dependent (8-11). Both rat and mouse models are currently employed in endometriosis research (11-18). …”

Section: Introductionmentioning

confidence: 99%

Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women

Pelch

Schroder

Kimball

et al. 2010

Fertility and Sterility

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Objective To define the altered gene expression profile of endometriotic lesions in a mouse model of surgically-induced endometriosis Design Autologous experimental mouse model. Setting Medical school department. Animals Adult C57Bl6 mice. Intervention(s) Endometriosis was surgically-induced by auto-transplantation of uterine tissue to the intestinal mesentery. Endometriotic lesions and eutopic uteri were recovered at 3 or 29 days post-induction. Main Outcome Measure(s) Altered gene expression was measured in the endometriotic lesion relative to the eutopic uterus by genome wide cDNA microarray analysis and was confirmed by real time RT-PCR for six genes. Relevant categories of altered genes were identified using gene ontology analysis to determine groups of genes enriched for altered expression. Result(s) The expression of 479 and 114 genes was altered in the endometriotic lesion compared to the eutopic uterus at 3 or 29 days post-induction, respectively. Gene ontology enrichment analysis revealed that genes associated with the extracellular matrix, cell adhesions, immune function, cell growth, and angiogenesis were altered in the endometriotic lesion compared to the eutopic uterus. Conclusion(s) Based on gene expression analysis, the mouse model of surgically-induced endometriosis appears to be a good model for studying the pathophysiology and treatment of endometriosis.

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Section: Introductionmentioning

confidence: 99%

Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women

Pelch

Schroder

Kimball

et al. 2010

Fertility and Sterility

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show abstract

“…The incidence of endometriosis is poorly estimated because of the multiple signs and symptoms, and by the lack of consistent definition criteria [1,2]. While several hypotheses concerning the origin of endometriosis have been proposed, none of them can explain the random expression in different tissues [3][4][5][6][7][8][9]. Nonetheless, the endometrium (END) most likely plays a role in the genesis of this disease [1,7,10].…”

Section: Introductionmentioning

confidence: 99%

Expression of stem cell-related genes in the endometrium and endometriotic lesions: a pilot study

Fettback

Pereira

Rocha

et al. 2015

Gynecological Endocrinology

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“… 1 , 2 Several studies have revealed a large number of genetic markers related to immune, neuroendocrine and reproductive functions present in high frequency among patients with endometriosis, indicating associations between the development of endometriosis and genetic polymorphisms. 3 - 6 …”

Section: Introductionmentioning

confidence: 99%

The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility

Gimenes

Bianco²,

Mafra³

et al. 2010

Clinics

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OBJECTIVE:This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis‐associated infertility, in infertile women without endometriosis and in controls.INTRODUCTION:The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors, and isoform B, which has the capacity to activate the estrogen receptors. Several polymorphisms have been described for this gene, among which one stands out: a polymorphism named PROGINS, which has been speculated to be related to the genesis of endometriosis by several studies with conflicting results.METHODS:This was a prospective study that included 148 patients with endometriosis‐associated infertility, 50 idiopathic infertile patients and 179 fertile women as controls. The PROGINS polymorphism was studied by PCR.RESULTS:Genotypes P1P1, P1P2 and P2P2 (P2 representing the PROGINS polymorphism) of the progesterone receptor gene presented frequencies of 93.9%, 5.4% and 0.7%, respectively, in the women with endometriosis‐associated infertility (p = 0.2101, OR = 0.51, 95% CI = 0.24‐1.09); 94.4%, 4.2% and 1.4%, respectively, in the patients with minimal/mild endometriosis (p = 0.2725, OR = 0.53, 95% CI = 0.20‐1.43); 93.5%, 6.5% and 0%, respectively, among the patients with moderate/severe endometriosis (p = 0.3679, OR = 0.49, 95% CI = 0.18‐1.31); 86.0%, 14.0% and 0%, respectively, in idiopathic infertile women (p = 0.8146, OR = 1.10, 95% CI = 0.46‐2.63); and 88.3%, 10.6% and 1.1%, respectively, in the control group.CONCLUSION:The data suggest that PROGINS is not related either to endometriosis‐associated infertility or to idiopathic infertility in the population studied.

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Does Gestrinone Antagonize the Effects of Estrogen on Endometrial Implants Upon the Peritoneum of Rats?

Cited by 7 publications

References 30 publications

Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women

Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women

Expression of stem cell-related genes in the endometrium and endometriotic lesions: a pilot study

The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility

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