Analysis of the Clinicopathological Characteristics of Patients with Upper Urinary Tract Transitional Cell Carcinoma

Abstract

MATERIALS AND METHODS:The study comprised a retrospective analysis of 25 patients treated between February 1994 and August 2006. The variables analyzed were: patient age, gender, and clinical presentation; diagnostic methods; pathologic characteristics at the primary site of the tumor (pelvis or ureter); tumor stage and grade; and presence of carcinoma in situ, microvascular invasion and squamous differentiation. The Kaplan-Meier method and the Log-Rank test were used for statistical analysis of bladder recurrence-free survival. RESULTS: Eighty-four percent of patients were male, and macroscopic hematuria was the most common clinical presentation. The majority of cases (56%) were infiltrative (T2-T3) and high-grade (76%) tumors. Synchronous or metachronous bladder tumors were found in 72% of cases. Five (20%) patients had a history of bladder tumor before the diagnosis of upper urinary tract transitional cell carcinomas. The mean follow-up period was 36 months (range: 1.5 to 156). During the follow-up period, eleven (44%) patients developed bladder tumors. After five years, the probability of being free of bladder tumor recurrence was 40%. No pathological variable was predictive for bladder tumor recurrence. Four patients presented disease recurrence outside the urinary tract. CONCLUSIONS: The presence of metachronous bladder tumors is more often observed after the diagnosis of upper urinary tract transitional cell carcinomas. All of these patients should undergo rigorous follow-up during the postoperative period. Only patients with infiltrative and high-grade tumors developed metastases outside the urinary tract.

Primary urothelial carcinoma of the upper tract: Important clinicopathological factors predicting bladder recurrence after surgical resection

“…The incidence (23%) and duration from initial surgical intervention to the development of urinary bladder cancer recurrence in the present series were comparable with previous series 2–10,17 . When compared to previous reports, however, the urinary bladder cancer recurrence rate in the present series had a higher frequency of invasive lesions (T1–T4) 18 …”

“…Two recent series indicated that tumor multifocality was an independent predictor for urinary bladder cancer recurrence 2,18 . Intriguingly, these two series found diverse frequencies of multifocal tumors, at 6.8% and 27.0%, respectively.…”

<p>Pseudolaric Acid B Inhibits Proliferation, Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma Through Regulating CD147</p>

“…Even through there are comprehensive treatment options such as surgery, radiotherapy, and chemotherapy, the 5-year survival rate is only 15–25%. 3 , 4 In this process, the monomeric compounds of traditional Chinese medicine (TCM) play an important role in the antitumor toxicity reduction and synergism. 5 Therefore, it is of great significance to searching for a new drug that can block tumor metastasis with clear molecular targets, which has also become the focus in ESCC research.…”